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Distribution and Risk Factors for Plasmodium and Helminth Co-infections: A Cross-Sectional Survey among Children in Bagamoyo District, Coastal Region of Tanzania

April 3, 2015 - 09:57 -- Open Access
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Author(s): 
Nahya Salim, Stefanie Knopp, Blaise Genton, et al.
Reference: 
PLoS Negl Trop Dis 9(4): e0003660

The findings suggest that STH and Plasmodium infections tend to occur in the same children, with increasing prevalence of co-infection with age.

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NOT Open Access | Bacteremia and Malaria in Tanzanian Children Hospitalized for Acute Febrile Illness

April 2, 2015 - 07:43 -- NOT Open Access
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Author(s): 
Ingrid S. Lundgren, Sonya L. Heltshe, Arnold L. Smith, Jerome Chibwana, Michal W. Fried, and Patrick E. Duffy
Reference: 
J Trop Pediatr (2015) 61 (2): 81-85.

We recorded the reason for presentation to a rural hospital in an area endemic for malaria in 909 children between January 2006 and March 2009.

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NOT Open Access | Laboratory confirmation of clinically diagnosed malaria in a cohort of HIV-infected mothers and their children in Malawi

March 25, 2015 - 15:38 -- NOT Open Access
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Author(s): 
Marina Giuliano, Clementina Maria Galluzzo, Leonardo Palombi, et al.
Reference: 
J Trop Pediatr (2015)

To avoid overdiagnosis, accuracy in the identification of true malaria cases is of critical importance.

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Artemether-lumefantrine versus artemisinin-naphthoquine in Papua New Guinean children with uncomplicated malaria: a six months post-treatment follow-up study

March 23, 2015 - 12:09 -- Open Access
Author(s): 
Moses Laman, John M Benjamin, Brioni R Moore, Mary Salib, Somoyang Tawat, Wendy A Davis, Peter M Siba, Leanne J Robinson, Timothy Davis
Reference: 
Malaria Journal 2015, 14:121 (21 March 2015)

The greater effectiveness of artemisinin-NQ over conventional AM-LM extends to at least six months post-treatment for clinical malaria but not non-malarial illness.

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Comparison of azithromycin plus chloroquine versus artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in children in Africa: a randomized, open-label study

March 16, 2015 - 14:08 -- Open Access
Author(s): 
Richa Chandra, Patrick Ansah, Issaka Sagara, Ali Sie, Alfred B Tiono, Abdoulaye A Djimde, Qinying Zhao, Jeffery Robbins, Louis K Penali, Bernhards Ogutu
Reference: 
Malaria Journal 2015, 14:108 (10 March 2015)

In this study, non-inferiority of AZCQ to AL was not demonstrated.

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Poor adherence to the malaria management protocol among health workers attending under-five year old febrile children at Omdurman Hospital, Sudan

February 25, 2015 - 14:55 -- Open Access
Author(s): 
Jalal A Bilal, Gasim I Gasim, Mohamed T Abdien, Khalid A Elmardi, Elfatih M Malik, Ishag Adam
Reference: 
Malaria Journal 2015, 14:34 (28 January 2015)

This study aimed to investigate the adherence to malaria national protocol for the management of malaria among under five years old children.

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Prospective validation of pediatric disease severity scores to predict mortality in Ugandan children presenting with malaria and non-malaria febrile illness

February 24, 2015 - 16:37 -- Open Access
Author(s): 
Andrea L Conroy, Michael Hawkes, Kyla Hayford, Sophie Namasopo, Robert O Opoka, Chandy C John, W Conrad Liles and Kevin C Kain
Reference: 
Critical Care 2015, 19:47

We evaluated the ability of three clinical scoring systems to predict in-hospital mortality in a prospective observational study of Ugandan children with fever. We computed the Lambaréné Organ Dysfunction Score (LODS), Signs of Inflammation in Children that Kill (SICK), and the Pediatric Early Death Index for Africa (PEDIA).

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Randomized non-inferiority and safety trial of dihydroartemisin-piperaquine and artesunate-amodiaquine versus artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Cameroonian children

February 11, 2015 - 16:25 -- Open Access
Author(s): 
Akindeh M Nji, Innocent M Ali, Wilfred F Mbacham, et al.
Reference: 
Malaria Journal 2015, 14:27 (28 January 2015)

ASAQ and DHAP are considered safe and tolerable and are not inferior to AL in the treatment of uncomplicated P. falciparum malaria in Cameroonian children.

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Efficacy and Safety of Fixed-Dose Artesunate-Amodiaquine vs. Artemether-Lumefantrine for Repeated Treatment of Uncomplicated Malaria in Ugandan Children

December 18, 2014 - 06:15 -- Open Access
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Author(s): 
Adoke Yeka, Valerie Lameyre, Kibuuka Afizi, Mudangha Fredrick, Robinson Lukwago, Moses R. Kamya, Ambrose O. Talisuna
Reference: 
PLoS ONE 9(12): e113311

The safety and efficacy of the two most widely used fixed-dose artemisinin-based combination therapies (ACT), artesunate-amodiaquine (ASAQ) and artemether-lumefantrine (AL) are well established for single episodes of uncomplicated Plasmodium falciparum malaria, but the effects of repeated, long-term use are not well documented.

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The outcome of a test-treat package versus routine outpatient care for Ghanaian children with fever: a pragmatic randomized control trial

December 10, 2014 - 16:28 -- Open Access
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Author(s): 
Emmanuel Ameyaw, Samuel B Nguah, Daniel Ansong, Iain Page, Martine Guillerm, Imelda Bates
Reference: 
Malaria Journal 2014, 13:461 (26 November 2014)

Test-treat package improves the effectiveness of outpatient diagnosis and treatment of children with fever and reduces inappropriate prescribing of anti-malarials and antibiotics.

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