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Seasonal and temporal trends in all-cause and malaria mortality in rural Burkina Faso, 1998–2007

August 6, 2015 - 05:32 -- Open Access
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Author(s): 
Eveline Otte im Kampe, Olaf Müller, Ali Sie, Heiko Becher
Reference: 
Malaria Journal 2015, 14:300 (5 August 2015)

Malaria mortality remains highly seasonal in rural Burkina Faso.

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Decline of FoxP3+ Regulatory CD4 T Cells in Peripheral Blood of Children Heavily Exposed to Malaria

July 22, 2015 - 10:41 -- Open Access
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Author(s): 
Michelle J. Boyle, Prasanna Jagannathan, Margaret E. Feeney, et al.
Reference: 
PLoS Pathog 11(7): e1005041

FoxP3+ regulatory CD4 T cells (Tregs) help to maintain the delicate balance between pathogen-specific immunity and immune-mediated pathology.

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Genome-Wide Identification of the Target Genes of AP2-O, a Plasmodium AP2-Family Transcription Factor

June 2, 2015 - 13:28 -- Open Access
Author(s): 
Izumi Kaneko, Shiroh Iwanaga, Tomomi Kato, Issei Kobayashi, Masao Yuda
Reference: 
PLoS Pathog 11(5): e1004905

Stage-specific transcription is a fundamental biological process in the life cycle of the Plasmodium parasite.

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NOT Open Access | Impact of Antimalarial Treatment and Chemoprevention on the Drug Sensitivity of Malaria Parasites Isolated from Ugandan Children

May 18, 2015 - 13:05 -- NOT Open Access
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Author(s): 
Patrick Tumwebaze, Melissa D. Conrad, Philip J. Rosenthal, et al.
Reference: 
Antimicrob. Agents Chemother. June 2015 vol. 59 no. 6 3018-3030

Changing treatment practices may be selecting for changes in the drug sensitivity of malaria parasites.

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The Association between Nutritional Status and Malaria in Children from a Rural Community in the Amazonian Region: A Longitudinal Study

May 4, 2015 - 08:30 -- Open Access
Author(s): 
Márcia Almeida Araújo Alexandre, Silvana Gomes Benzecry, Andre Machado Siqueira, Sheila Vitor-Silva, Gisely Cardoso Melo, Wuelton Marcelo Monteiro, Heitor Pons Leite, Marcus Vinícius Guimarães Lacerda, Maria das Graças Costa Alecrim
Reference: 
PLoS Negl Trop Dis 9(4): e0003743

Malaria was associated with impaired nutritional status amongst children in an endemic area of the Western Brazilian Amazon where P. vivax predominates.

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NOT Open Access | Coinfection with Blood-Stage Plasmodium Promotes Systemic Type I Interferon Production during Pneumovirus Infection but Impairs Inflammation and Viral Control in the Lung

April 30, 2015 - 12:50 -- NOT Open Access
Author(s): 
Chelsea L. Edwards, Vivian Zhang, Ashraful Haque, et al.
Reference: 
Clin Vaccine Immunol May 2015 vol. 22 no. 5 477-483

Acute lower respiratory tract infections (ALRTI) are the leading cause of global childhood mortality, with human respiratory syncytial virus (hRSV) being a major cause of viral ALRTI in young children worldwide.

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Monitoring the efficacy of artemether-lumefantrine for the treatment of uncomplicated malaria in Malawian children

April 24, 2015 - 08:56 -- Open Access
Author(s): 
Rosalia Dambe, John Sande, Doreen Ali, Ben Chilima, Wilfred Dodoli, Charles C Michelo, Grace Malenga, Kamija S Phiri
Reference: 
Malaria Journal 2015, 14:175 (23 April 2015)

There is evidence of good efficacy of AL in Malawi notwithstanding geographical contrasts and this supports the continued use of AL as the first-line treatment for uncomplicated malaria.

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Outdoor biting by Anopheles mosquitoes on Bioko Island does not currently impact on malaria control

April 24, 2015 - 07:08 -- Open Access
Author(s): 
John Bradley, Jo Lines, Godwin Fuseini, Christopher Schwabe, Feliciano Monti, Michel Slotman, Daniel Vargas, Guillermo Garcia, Dianna Hergott, Immo Kleinschmidt
Reference: 
Malaria Journal 2015, 14:170 (21 April 2015)

Malaria vector mosquitoes in Bioko do bite humans outdoors, and this has the potential to reduce the effectiveness of vector control.

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Distribution and Risk Factors for Plasmodium and Helminth Co-infections: A Cross-Sectional Survey among Children in Bagamoyo District, Coastal Region of Tanzania

April 3, 2015 - 09:57 -- Open Access
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Author(s): 
Nahya Salim, Stefanie Knopp, Blaise Genton, et al.
Reference: 
PLoS Negl Trop Dis 9(4): e0003660

The findings suggest that STH and Plasmodium infections tend to occur in the same children, with increasing prevalence of co-infection with age.

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