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children

Inhaled nitric oxide as adjunctive therapy for severe malaria: a randomized controlled trial

November 4, 2015 - 11:50 -- Open Access
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Author(s): 
Michael Hawkes, Andrea Conroy, Kevin Kain, et al.
Reference: 
Malaria Journal 2015, 14:421 (29 October 2015)

iNO at 80 ppm administered by non-rebreather mask was safe but did not affect circulating levels of Ang-2.

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NOT Open Access | Investigating proteasome inhibitors as potential adjunct therapies for experimental cerebral malaria

October 28, 2015 - 06:06 -- NOT Open Access
Author(s): 
S. W. Howland, G. X. P. Ng, S. K. Chia and L. Rénia
Reference: 
Parasite Immunology, Volume 37, Issue 11, pages 599–604, November 2015

Aside from antimalarials, there is currently no treatment for cerebral malaria, a fulminant neurological complication of P. falciparum infection that is a leading cause of death in African children.

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Not Open Access | Targeting glutamine metabolism rescues mice from late-stage cerebral malaria

October 27, 2015 - 07:25 -- NOT Open Access
Author(s): 
Emile B. Gordon, Geoffrey T. Hart, Susan K. Pierce, et al.
Reference: 
PNAS October 20, 2015 vol. 112 no. 42 13075-13080

The most deadly complication of Plasmodium falciparum infection is cerebral malaria (CM) with a case fatality rate of 15–25% in African children despite effective antimalarial chemotherapy.

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Variable piperaquine exposure significantly impacts protective efficacy of monthly dihydroartemisinin-piperaquine for the prevention of malaria in Ugandan children

September 28, 2015 - 16:48 -- Open Access
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Author(s): 
Kerstin Sundell, Prasanna Jagannathan, Liusheng Huang, Victor Bigira, James Kapisi, Mary Kakuru, Rada Savic, Moses Kamya, Grant Dorsey, Francesca Aweeka
Reference: 
Malaria Journal 2015, 14:368 (24 September 2015)

The protective efficacy of DHA/PQ chemoprevention in young children was strongly associated with higher drug exposure; in children with the highest PQ exposure, monthly DHA/PQ chemoprevention was nearly 100 % protective against malaria.

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The effect of iron-fortified complementary food and intermittent preventive treatment of malaria on anaemia in 12- to 36-month-old children: a cluster-randomised controlled trial

September 22, 2015 - 16:09 -- Open Access
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Author(s): 
Dominik Glinz, Richard Hurrell, Rita Wegmüller, et al.
Reference: 
Malaria Journal 2015, 14:347 (17 September 2015)

IPT alone only modestly decreased anaemia, but neither IPT nor iron fortified CF significantly improved Hb concentration after 9 months.

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Hypoxemia predicts death from severe falciparum malaria among children under 5 years of age in Nigeria: the need for pulse oximetry in case management.

September 22, 2015 - 16:07 -- Open Access
Author(s): 
Adebola Orimadegun, Babatunde Ogunbosi, Bose Orimadegun
Reference: 
Afr Health Sci. 2014 Jun;14(2):397-407

To investigate the prevalence and predictive value of hypoxaemia for deaths in under-5s with severe falciparum malaria infection.

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Effect of zinc added to a daily small-quantity lipid-based nutrient supplement on diarrhoea, malaria, fever and respiratory infections in young children in rural Burkina Faso: a cluster-randomised trial

September 15, 2015 - 16:03 -- Open Access
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Author(s): 
Jérôme W Somé, Souheila Abbeddou, Elizabeth Yakes Jimenez, Sonja Y Hess, Zinéwendé P Ouédraogo, Rosemonde M Guissou, Stephen A Vosti, Jean-Bosco Ouédraogo, Kenneth H Brown
Reference: 
BMJ Open 2015;5:e007828

Inclusion of 5 or 10 mg zinc in SQ-LNS and provision of 5 mg zinc dispersible tablet along with SQ-LNS had no impact on the incidence of diarrhoea, malaria and fever or the longitudinal prevalence of RTI compared with SQ-LNS without zinc in this population.

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Frequency of RANTES gene polymorphisms and their association with incidence of malaria: a longitudinal study on children in Iganga district, Uganda

September 7, 2015 - 11:22 -- Open Access
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Author(s): 
Catherine Lwanira, Mark Mukasa, Göte Swedberg, Fred Kironde
Reference: 
Malaria Journal 2015, 14:341 (5 September 2015)

This study showed that the −403A mutation occurs in nearly half of the study population and the In1.1C allele occurs in one in every four children.

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Anti-malarial prescription practices among children admitted to six public hospitals in Uganda from 2011 to 2013

August 31, 2015 - 15:59 -- Open Access
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Author(s): 
Asadu Sserwanga, David Sears, Arthur Mpimbaza, et al.
Reference: 
Malaria Journal 2015, 14:331 (27 August 2015)

Despite high testing rates for malaria at all sites, prescription of anti-malarials to patients with negative test results remained high, with the exception of one site where a steady decline occurred.

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Development of a text-messaging intervention to improve treatment adherence and post-treatment review of children with uncomplicated malaria in western Kenya

August 24, 2015 - 17:36 -- Open Access
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Author(s): 
Sophie Githinji, Caroline Jones, Josephine Malinga, Robert W Snow, Ambrose Talisuna, Dejan Zurovac
Reference: 
Malaria Journal 2015, 14:320 (19 August 2015)

Text message interventions should be carefully developed, tested and refined before implementation to ensure they are written in the most appropriate way for their target population.

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