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Intramuscular Artesunate for Severe Malaria in African Children: A Multicenter Randomized Controlled Trial

February 8, 2016 - 16:45 -- Open Access
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Author(s): 
Peter G. Kremsner, Akim A. Adegnika, Sanjeev Krishna, et al.
Reference: 
PLoS Med 13(1): e1001938

A simplified three-dose i.m. regimen for severe malaria in African children is non-inferior to the more complex WHO-recommended regimen.

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Lack of K13 mutations in Plasmodium falciparum persisting after artemisinin combination therapy treatment of Kenyan children

January 29, 2016 - 18:36 -- Open Access
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Author(s): 
Julian Muwanguzi, Gisela Henriques, Patrick Sawa, Teun Bousema, Colin J. Sutherland and Khalid B. Beshir
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Malaria Journal 2016 15:36, 22 January 2016

This study contributes to the ongoing surveillance of suspected artemisinin resistance parasites in Africa by providing baseline prevalence of k13-propeller mutations in western Kenya with samples collected from a longitudinal study.

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Characteristics of asymptomatic Plasmodium spp. parasitaemia in Kwahu-Mpraeso, a malaria endemic mountainous district in Ghana, West Africa

January 28, 2016 - 16:30 -- Open Access
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Author(s): 
Ewurama D. A. Owusu, Vincent Buabeng, Samuel Dadzie, Charles A. Brown, Martin P. Grobusch and Petra Mens
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Malaria Journal 2016 15:38, 22 January 2016

For an effective malaria control in this area, interventions should be formulated and implemented to target asymptomatic parasite reservoirs; especially in children and people with Hb AC.

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Dysregulation of the haem-haemopexin axis is associated with severe malaria in a case–control study of Ugandan children

December 29, 2015 - 15:25 -- Open Access
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Author(s): 
Robyn Elphinstone, Frank Riley, Kevin Kain, et al.
Reference: 
Malaria Journal 2015, 14:511 (21 December 2015)

These data indicate that plasma levels of haemin and haemopexin measured at presentation correlate with malaria severity and levels of haemin and cell-free haemoglobin predict outcome in paediatric severe malaria.

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Social inequalities in malaria knowledge, prevention and prevalence among children under 5 years old and women aged 15–49 in Madagascar

December 16, 2015 - 15:52 -- Open Access
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Author(s): 
Sean Clouston, Josh Yukich, Phil Anglewicz
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Malaria Journal 2015, 14:499 (12 December 2015)

Malaria may be subject to socio-economic forces arising from a broad set of behavioural and geographic determinants, even after adjusting for geographic risk factors and seasonality.

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Malaria, anaemia and under-nutrition: three frequently co-existing conditions among preschool children in rural Rwanda

November 10, 2015 - 07:13 -- Open Access
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Author(s): 
Fredrick Kateera, Chantal M. Ingabire, Emmanuel Hakizimana, Parfait Kalinda, Petra F. Mens, Martin P. Grobusch, Leon Mutesa and Michèle van Vugt
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Malaria Journal 2015, 14:440 (5 November 2015)

In this study group, four in 10 and one in 10 children were found stunted and underweight, respectively, in an area of low malaria transmission.

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Narrative review of current context of malaria and management strategies in Uganda (Part I)

November 10, 2015 - 05:24 -- Open Access
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Author(s): 
Rosemin Kassam, John B. Collins, Eric Liow, Nabeela Rasool
Reference: 
Acta Tropica, Volume 152, December 2015, Pages 252–268

In accordance with international targets, the Uganda National Malaria Control Strategic Plan established specific targets to be achieved by 2010.

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Abolishing Fees at Health Centers in the Context of Community Case Management of Malaria: What Effects on Treatment-Seeking Practices for Febrile Children in Rural Burkina Faso?

November 5, 2015 - 05:17 -- Open Access
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Author(s): 
Thomas Druetz, Federica Fregonese, Aristide Bado, Tieba Millogo, Seni Kouanda, Souleymane Diabaté, Slim Haddad
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PLoS ONE 10(10): e0141306

User fees abolition reduced visit delay for febrile children living close to health centers.

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A randomized trial of the efficacy of artesunate and three quinine regimens in the treatment of severe malaria in children at the Ebolowa Regional Hospital, Cameroon

November 4, 2015 - 13:54 -- Open Access
Author(s): 
Daniel Maka, Andreas Chiabi, Valentine Ndikum, Dorothy Achu, Evelyn Mah, Séraphin Nguefack, Pamela Nana, Zakariaou Njoumemi, Wilfred Mbacham, Elie Mbonda
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Malaria Journal 2015, 14:429 (31 October 2015)

Artesunate is more effective than quinine in the treatment of severe malaria in Cameroonian children.

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Artesunate-amodiaquine versus artemether-lumefantrine for the treatment of acute uncomplicated malaria in Congolese children under 10 years old living in a suburban area: a randomized study

November 4, 2015 - 11:55 -- Open Access
Author(s): 
Mathieu Ndounga, Pembe Issamou Mayengue, Francine Ntoumi, et al.
Reference: 
Malaria Journal 2015, 14:423 (29 October 2015)

This first randomized study in Brazzaville confirmed the excellent efficacy of these co-formulated anti-malarial drugs in children.

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