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NOT Open Access | Risk factors for Plasmodium falciparum and Plasmodium vivax gametocyte carriage in Papua New Guinean children with uncomplicated malaria

June 1, 2016 - 14:46 -- NOT Open Access
Author(s): 
Stephan Karl, Moses Laman, Timothy M.E. Davis, et al.
Reference: 
Acta Tropica Volume 160, August 2016, Pages 1–8

There are limited data on gametocytaemia risk factors before/after treatment with artemisinin combination therapy in children from areas with transmission of multiple Plasmodium species.

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NOT Open Access | Malaria and HIV among pediatric inpatients in two Tanzanian referral hospitals: A prospective study

May 23, 2016 - 14:48 -- NOT Open Access
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Author(s): 
Luke R. Smart, Neema Orgenes, Humphrey D. Mazigo, Mercy Minde, Adolfine Hokororo, Muhammad Shakir, Jaco J. Verweij, Jennifer A. Downs, Robert N. Peck
Reference: 
Acta Tropica, Volume 159, July 2016, Pages 36–43

Malaria remains common in sub-Saharan Africa, but it is frequently over-diagnosed and over-treated in hospitalized children.

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Delayed acquisition of Plasmodium falciparum antigen-specific CD4+ T cell responses in HIV-exposed uninfected Malawian children receiving daily cotrimoxazole prophylaxis

May 16, 2016 - 17:34 -- Open Access
Author(s): 
Herbert Longwe, Kamija S. Phiri, Nyanyiwe M. Mbeye, Thandile Gondwe, Wilson L. Mandala and Kondwani C. Jambo
Reference: 
Malaria Journal 2016 15:264

The results demonstrate that there is delayed acquisition of P. falciparum-specific IFN-γ-producing CD4+ T cells in HEU children on daily cotrimoxazole prophylaxis, which is evident at 6 and 12 months of age in comparison to HUU age-matched controls.

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Malaria illness mediated by anaemia lessens cognitive development in younger Ugandan children

April 14, 2016 - 17:08 -- Open Access
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Author(s): 
Michael J. Boivin, Alla Sikorskii, Grant Dorsey, et al.
Reference: 
Malaria Journal 2016 15:210, 14 April 2016

Malaria with anaemia and HIV exposure are significant risk factors for poor early childhood neurodevelopment in malaria-endemic areas in rural Africa.

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Identification of different malaria patterns due to Plasmodium falciparum and Plasmodium vivax in Ethiopian children: a prospective cohort study

April 14, 2016 - 17:02 -- Open Access
Author(s): 
Dinberu Seyoum, Yehenew Getachew Kifle, Virginie Rondeau, Delenasaw Yewhalaw, Luc Duchateau, Angel Rosas-Aguirre and Niko Speybroeck
Reference: 
Malaria Journal 2016 15:208, 14 April 2016

The analysis of all malaria episodes (first and recurrent episodes) in the malaria cohort suggests different species-specific patterns of malaria disease in children, with mild seasonality in the incidence of P. vivax episodes mostly observed in younger age groups, and with marked seasonality in the incidence of P. falciparum episodes mainly seen in older children.

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Association between malaria and malnutrition among children aged under-five years in Adami Tulu District, south-central Ethiopia: a case–control study

February 23, 2016 - 14:34 -- Open Access
Author(s): 
Shikur B, Deressa W, Lindtjørn B
Reference: 
BMC Public Health 2016, 16 :174 (19 February 2016)

Four hundred twenty eight under-five children comprising 107 cases and 321 controls were included in this study. Prevalence of wasting was higher among cases (17.8 %) than the controls (9.3 %). 

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Spatial heterogeneity of malaria in Ghana: a cross-sectional study on the association between urbanicity and the acquisition of immunity

February 15, 2016 - 14:32 -- Open Access
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Author(s): 
Clemens Frank, Ralf Krumkamp, Benno Kreuels, et al.
Reference: 
Malaria Journal 2016 15:84, 11 February 2016

The results confirm an association between an increase in urbanicity and declining malaria risk and demonstrate that the acquisition of semi-immunity is heterogeneous on a micro-epidemiological scale and is associated with urbanicity.

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Malaria, helminths, co-infection and anaemia in a cohort of children from Mutengene, south western Cameroon

February 9, 2016 - 16:51 -- Open Access
Author(s): 
Clarisse Njua-Yafi, Eric A. Achidi, Theresa Nkuo-Akenji, et al.
Reference: 
Malaria Journal 2016 15:69, 6 February 2016

Children below 5 years of age were more susceptible to malaria and anaemia.

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Endothelial activation, haemostasis and thrombosis biomarkers in Ugandan children with severe malaria participating in a clinical trial

February 8, 2016 - 17:10 -- Open Access
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Author(s): 
Susan M. Graham, Junmei Chen, W. Conrad Liles, et al.
Reference: 
Malaria Journal 2016 15:56, 2 February 2016

These results confirm that severe malaria is associated with endothelial activation, and suggest that endothelial activation contributes to microvascular thrombosis and endothelial damage.

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Increased adhesion of Plasmodium falciparum infected erythrocytes to ICAM-1 in children with acute intestinal injury

February 8, 2016 - 17:08 -- Open Access
Author(s): 
James A. Church, Lydia Nyamako, Peter Olupot-Olupot, Kathryn Maitland and Britta C. Urban
Reference: 
Malaria Journal 2016 15:54, 1 February 2016

Increased parasite adhesion to ICAM-1 in children with evidence of intestinal ischaemia lends further evidence to a link between the cytoadherence of iRBCs in gut microvasculature and intestinal damage.

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