The study reports on the relationship between delay in parasite clearance and anti-malarial treatment failure in children with falciparum malaria in an area of intense transmission in south-western Nigeria.
The diagnosis of cerebral malaria (CM) is difficult to confirm in endemic regions with limited neurodiagnostics. Accurate diagnoses are critical for trials and outcomes studies.
A choice of method to measure body temperature for diagnosis of fever in African children should be informed by a trade off between its specificity and sensitivity that considers thresholds > 38.0°C.
We have, therefore, undertaken a pooled analysis of existing data from multiple sites to enable a comprehensive overview of the age-patterns of malaria outcomes under different epidemiological conditions in sub-Saharan Africa.
The conclusion of the study is that children who experienced mild, moderate or severe stunting were not more likely to have asymptomatic malaria than children who were not stunted.
Taking into account the environmental persistence and the toxicity of DDT, the Pan American Health Organization (PAHO) organized a surveillance program in Mesoamerica which included the detection of residual DDT in environmental (soil) and biological samples (fish tissue and children’s blood).
Conducted in 2004-2006, the results of this study give updated information about anti-malarials efficacy at the time of policy change to ACT treatment (AQ used in combination with artesunate and SP used in IPT for pregnant women.
Both RDTs were highly sensitive, met WHO standards for the detection of falciparum malaria monoinfections where parasitaemia was >100 parasites/mul and were easy to use. CareStartTM persistent false positivity decreased quickly after successful anti-malarial treatment, making it a good choice for a RDT for a hyperendemic falciparum malaria area.
These data provide, for the first time, evidence for improved management of children by use of paediatric formulations, and support the further development and use of paediatric ACTs.
Children with severe malaria and metabolic acidosis have evidence of hypovolemia and evidence of cardiac dysfunction.