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Open Access | Factors contributing to delay in parasite clearance in uncomplicated falciparum malaria in children

February 17, 2010 - 20:32 -- Ingeborg van Schayk
Author(s): 
Akintunde Sowunmi, Elsie O Adewoye, Grace O Gbotsho, Christian T Happi, Abayomi Sijuade, Onikepe A Folarin, Titilope M Okuboyejo, Obaro S Michael
Reference: 
Malaria Journal 2010, 9:53 (15 February 2010)

The study reports on the relationship between delay in parasite clearance and anti-malarial treatment failure in children with falciparum malaria in an area of intense transmission in south-western Nigeria.

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Identification of Malaria Retinopathy Improves the Specificity of the Clinical Diagnosis of Cerebral Malaria: Findings from a Prospective Cohort Study

February 11, 2010 - 13:31 -- Ingeborg van Schayk
Author(s): 
Gretchen L. Birbeck, Nicholas Beare, Susan Lewallen, Simon J. Glover, Malcolm E. Molyneux, Peter W. Kaplan, AND Terrie E. Taylor
Reference: 
Am J Trop Med Hyg 2010;82 231-234

The diagnosis of cerebral malaria (CM) is difficult to confirm in endemic regions with limited neurodiagnostics. Accurate diagnoses are critical for trials and outcomes studies.

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Brief report: Assessment of Fever in African Children: Implication for Malaria Trials

February 10, 2010 - 21:21 -- Ingeborg van Schayk
Author(s): 
Sunny Oyakhirome, Katharina Profanter, AND Peter G. Kremsner
Reference: 
Am J Trop Med Hyg 2010;82 215-218

A choice of method to measure body temperature for diagnosis of fever in African children should be informed by a trade off between its specificity and sensitivity that considers thresholds > 38.0°C.

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Open Access | Age-Patterns of Malaria Vary with Severity, Transmission Intensity and Seasonality in Sub-Saharan Africa: A Systematic Review and Pooled Analysis

February 9, 2010 - 12:47 -- Ingeborg van Schayk
Author(s): 
Ilona Carneiro, Arantxa Roca-Feltrer, Jamie T. Griffin, Lucy Smith, Marcel Tanner, Joanna Armstrong Schellenberg, Brian Greenwood, David Schellenberg
Reference: 
PLoS ONE 5(2): e8988

We have, therefore, undertaken a pooled analysis of existing data from multiple sites to enable a comprehensive overview of the age-patterns of malaria outcomes under different epidemiological conditions in sub-Saharan Africa.

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Open Access | Exploring the relationship between chronic undernutrition and asymptomatic malaria in Ghanaian children

February 2, 2010 - 21:17 -- Ingeborg van Schayk
Author(s): 
Benjamin T Crookston, Stephen C Alder, Daniel Ansong, et al.
Reference: 
Malaria Journal 2010, 9:39 (2 February 2010)

The conclusion of the study is that children who experienced mild, moderate or severe stunting were not more likely to have asymptomatic malaria than children who were not stunted.

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Assessment of DDT levels in selected environmental media and biological samples from Mexico and Central America

February 1, 2010 - 10:28 -- Ingeborg van Schayk
Author(s): 
ván N. Pérez-Maldonado, Antonio Trejo, Fernando Díaz-Barriga et al.
Reference: 
Chemosphere Article in Press, Corrected Proof

Taking into account the environmental persistence and the toxicity of DDT, the Pan American Health Organization (PAHO) organized a surveillance program in Mesoamerica which included the detection of residual DDT in environmental (soil) and biological samples (fish tissue and children’s blood).

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Open Access | Efficacy of amodiaquine, sulphadoxine-pyrimethamine and their combination for the treatment of uncomplicated Plasmodium falciparum malaria in children in Cameroon at the time of policy change to artemisinin-based combination therapy

January 29, 2010 - 15:07 -- Ingeborg van Schayk
Author(s): 
Wilfred F Mbacham, Marie-Solange B Evehe, Palmer M Netongo, Isabel A Ateh, Patrice N Mimche, Anthony Ajua, Akindeh M Nji, Justin B Echouffo-Tcheugui, Bantar Tawe, Rachel Hallett, Cally Roper, Geoffrey Targett, Brian Greenwood
Reference: 
Malaria Journal 2010, 9:34 (27 January 2010)

Conducted in 2004-2006, the results of this study give updated information about anti-malarials efficacy at the time of policy change to ACT treatment (AQ used in combination with artesunate and SP used in IPT for pregnant women.

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Open Access | Assessment of two malaria rapid diagnostic tests in children under five years of age, with follow-up of false-positive pLDH test results, in a hyperendemic falciparum malaria area, Sierra Leone

January 29, 2010 - 14:23 -- Ingeborg van Schayk
Author(s): 
Sibylle Gerstl, Sophie Dunkley, Ahmed Mukhtar, Martin De Smet, Samuel Baker, Jacob Maikere
Reference: 
Malaria Journal 2010, 9:28 (21 January 2010)

Both RDTs were highly sensitive, met WHO standards for the detection of falciparum malaria monoinfections where parasitaemia was >100 parasites/mul and were easy to use. CareStartTM persistent false positivity decreased quickly after successful anti-malarial treatment, making it a good choice for a RDT for a hyperendemic falciparum malaria area.

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Review: Do paediatric drug formulations of artemisinin combination therapies improve the treatment of children with A systematic review and meta-analysis

January 28, 2010 - 12:47 -- Kabogo Ndegwa
Author(s): 
Florian Kurth, Sabine Bélard, Ayola A Adegnika, Prof Oumar Gaye, Prof Peter G Kremsner, and Dr Michael Ramharter
Reference: 
The Lancet Infectious Diseases, Volume 10, Issue 2, February 2010, Pages 125-132

These data provide, for the first time, evidence for improved management of children by use of paediatric formulations, and support the further development and use of paediatric ACTs.

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Cardiac function and hemodynamics in children in Africa with severe malaria

January 26, 2010 - 12:42 -- Ingeborg van Schayk
Author(s): 
Yacoub, Sophie; Lang, Hans-Joerg; Shebbe, Mohammed; Timbwa, Molline; Ohuma, Eric; Tulloh, Robert; Maitland, Kathryn
Reference: 
Critical Care Medicine: POST COPYEDIT, 14 January 2010

Children with severe malaria and metabolic acidosis have evidence of hypovolemia and evidence of cardiac dysfunction.

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