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The Levels of CD16/Fc Receptor IIIA on CD14+ CD16+ Monocytes Are Higher in Children with Severe Plasmodium falciparum Anemia than in Children with Cerebral or Uncomplicated Malaria

April 19, 2010 - 13:51 -- Patrick Sampao
Author(s): 
Lilian A. Ogonda,Alloys S. S. Orago, Michael F. Otieno, Christine Adhiambo, Walter Otieno and José A. Stoute
Reference: 
Infection and Immunity, Vol. 78, No. 5, p. 2173-2181 May 2010

These data suggest that monocytes of children with SMA respond differently to Plasmodium falciparum infection by overexpressing CD16/FcRIIIA as they mature, which could enhance erythrophagocytosis and TNF production.

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Transmission and Cross-Mating of High-Level Resistance Plasmodium falciparum Dihydrofolate Reductase Haplotypes in The Gambia

April 13, 2010 - 09:05 -- Patrick Sampao
Author(s): 
Amani Kheir, Davis Nwakanma, Aisha Al-Gazali, Yagut Akbarova, Salma Al-Saai, Göte Swedberg, AND Hamza A. Babiker
Reference: 
American Journal of Tropical Medicine Hygiene, Vol 82 : 4, 2010, pp. 535-541

Similarities were seen between pfg377 and MSP-1 alleles in children and mosquitoes and evidence of cross-mating between different parasite genotypes was seen in some infected mosquitoes, reflecting high transmission success of existing clones.

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TLR9 Polymorphisms Are Associated with Altered IFN-{gamma} Levels in Children with Cerebral Malaria

April 13, 2010 - 08:32 -- Patrick Sampao
Author(s): 
Nadia A. Sam-A., Jennifer A. G., et al
Reference: 
American Journal of Tropical Medicine Hygiene, Vol 82 : 4, 2010, pp. 548-555

We present the first human data that TLR SNPs are associated with altered cytokine production in parasitic infection.

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Syndromic Diagnosis of Malaria in Rural Sierra Leone and Proposed Additions to the National Integrated Management of Childhood Illness Guidelines for Fever

April 13, 2010 - 08:08 -- Patrick Sampao
Author(s): 
Obinna N. Nnedu, Bryan Rimel, Carey Terry, Heidi Jalloh-Vos, Brima Baryon, AND Daniel G. Bausch
Reference: 
American Journal of Tropical Medicine Hygiene, Vol 82 : 4, 2010, pp. 525-528

In a multivariate analysis, splenomegaly (P = 0.04) was the only clinical sign significantly associated with laboratory-confirmed malaria, and sleeping under a bed net was protective (P = 0.05). Our findings show that clinical malaria is diagnosed relatively accurately in rural Sierra Leone.

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Efficacy and safety of a new pediatric artesunate-mefloquine drug formulation for the treatment of uncomplicated falciparum malaria in Gabon

April 8, 2010 - 12:50 -- Kabogo Ndegwa
Author(s): 
MK Bouyou-Akotet, M Ramharter, EB Ngoungou, MM Mamfoumbi, MP Mihindou, MA Missinou, F Kurth, S Bélard, ST Agnandji, S Issifou, JL Heidecker, S Trapp, PG Kremsner, M Kombila
Reference: 
Wiener Klinische Wochenschrift, Volume 122, Numbers 5-6 / March, 2010 Pages 173-178

Pediatric drug formulations of artemisinin combination therapies are urgently needed for improving the treatment of children suffering from uncomplicated malaria. The aim of this clinical trial was to evaluate the efficacy, safety and tolerability of a novel pediatric fixed-dose granule formulation of artesunate-mefloquine and a new co-blister tablet formulation.

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Unusual presentations of malaria in children: An experience from a tertiary care centre in North East India

April 8, 2010 - 08:30 -- Kabogo Ndegwa
Author(s): 
R Dass, H Barman, SG Duwarah, NM Deka, P Jain, V Choudhury
Reference: 
Indian Journal of Pediatrics, March 31, 2010

Malaria is a common disease, but both typical and atypical presentations deserve attention for early diagnosis and management.

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Neuroimaging findings in children with retinopathy-confirmed cerebral malaria

April 6, 2010 - 15:56 -- Kabogo Ndegwa
Author(s): 
Michael J. Potchen, Gretchen L. Birbeck, J. Kevin DeMarco, Sam D. Kampondeni, Nicholas Beare, Malcolm E. Molyneux, Terrie E. Taylor
Reference: 
European Journal of Radiology, Volume 74, Issue 1, April 2010, Pages 262-268

The identification of pre-existing imaging abnormalities in acute cerebral malaria suggests that population-based studies are required to establish the rate and nature of incidental imaging abnormalities in Malawi.

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Open Access | Polymorphisms in genes of interleukin 12 and its receptors and their association with protection against severe malarial anaemia in children in western Kenya

April 6, 2010 - 11:36 -- Ingeborg van Schayk
Author(s): 
Lyna Zhang, Donald Prather, Jodi Vanden Eng, Sara Crawford, Simon Kariuki, Feiko ter Kuile, Dianne Terlouw, Bernard Nahlen, Altaf A Lal, Laurence Slutsker, Venkatachalam Udhaykumar, Ya Ping Shi
Reference: 
Malaria Journal 2010, 9:87 (29 March 2010)

This study has shown strong associations between polymorphisms in the genes of IL12A and IL12RB1 and protection from SMA in Kenyan children, suggesting that human genetic variants of IL12 related genes may significantly contribute to the development of anaemia in malaria patients.

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Open Access | Clinical Therapeutics: Amodiaquine Dosage and Tolerability for Intermittent Preventive Treatment To Prevent Malaria in Children

February 25, 2010 - 13:49 -- Kabogo Ndegwa
Author(s): 
M. Cairns, B. Cisse, C. Sokhna, C. Cames, K. Simondon, E. H. Ba, J.-F. Trape, O. Gaye, B. M. Greenwood, and P. J. M. Milligan
Reference: 
Antimicrobial Agents and Chemotherapy, March 2010, Pages 1265-1274, Volume 54, No. 3

We determined the association between amodiaquine dosage by body weight and mild adverse events (AEs) and investigated whether alternative age-based regimens could improve dosing accuracy and tolerability, using data from two trials of IPTc in Senegal, one in which AQ dose was determined by age and the other in which it was determined by weight category.

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Case Report: Molecular method for the diagnosis of imported pediatric malaria

February 19, 2010 - 12:16 -- Kabogo Ndegwa
Author(s): 
L. Delhaes Jeanne, A. Berry, E. Dutoit, F. Leclerc, J. Beaudou, S. Leteurtre, D. Camus, F. Benoit-Vical
Reference: 
Médecine et Maladies Infectieuses, Volume 40, Issue 2, February 2010, Pages 115-118

We report a case of imported malaria in a boy, illustrating the epidemiological and clinical aspects of severe pediatric malaria.

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