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Open Access | Effect of nutrient deficiencies on in vitro Th1 and Th2 cytokine response of peripheral blood mononuclear cells to Plasmodium falciparum infection

June 15, 2010 - 08:46 -- Kabogo Ndegwa
Author(s): 
Mbugi EV, Meijerink M, Veenemans J, Jeurink PV, McCall M, Olomi RM, Shao JF, Chilongola JO, Verhoef H, Savelkoul HF
Reference: 
Malaria Journal 2010, 9:162 (14 June 2010)

The pathological sequels of malaria potentially depend more on the balance between type I and type II cytokine responses than on absolute suppression of these cytokines and this balance may be influenced by a combination of micronutrient deficiencies and malaria status.

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Fever, malaria and primary repetition rates amongst school children in Mali: Combining demographic and health surveys (DHS) with spatial malariological measures

June 14, 2010 - 13:43 -- Patrick Sampao
Author(s): 
Josselin Thuilliez
Reference: 
Social Science & Medicine, Volume 71, Issue 2, July 2010, Pages 314-323

This study estimates the relative importance to child school performance (indicated by primary repetition) of fever, malaria and some social determinants at the cluster level.

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Open Access | Murine malaria is associated with significant hearing impairment

June 14, 2010 - 13:10 -- Kabogo Ndegwa
Author(s): 
Schmutzhard J, Kositz CH, Lackner P, Dietmann A, Fischer M, Glueckert R, Reindl M, Stephan K, Riechelmann H, Schrott-Fischer A, Schmutzhard E
Reference: 
Malaria Journal 2010, 9:159 (11 June 2010)

Plasmodium falciparum malaria has been suspected to cause hearing loss. Developmental, cognitive and language disorders have been observed in children, surviving cerebral malaria.

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Tolerability and efficacy of a pediatric granule formulation of artesunate-mefloquine in young children from cameroon with uncomplicated falciparum malaria

June 9, 2010 - 08:06 -- Kabogo Ndegwa
Author(s): 
F Tietche, D Chelo, NK Mina Ntoto, FM Djoukoue, C Hatz, S Frey, A Frentzel, S Trapp, R Zielonka, EA Mueller
Reference: 
Am. J. Trop. Med. Hyg., 82(6), 2010, pp. 1034-1040

A fixed-dose pediatric formulation of artesunate and mefloquine (Artequin Pediatric) has been developed. In this open, non-comparative study in Cameroonian children with uncomplicated falciparum malaria, the safety and efficacy of this formulation was tested, with a particular emphasis on the risk of neuropsychiatric adverse events (AEs). In total, 220 subjects, weighing between 10 and 20 kg, were enrolled; 213 qualified for analysis.

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Open Access | The economic costs of malaria in four Kenyan districts: do household costs differ by disease endemicity?

June 3, 2010 - 08:11 -- Kabogo Ndegwa
Author(s): 
Chuma J, Okungu V, Molyneux C
Reference: 
Malaria Journal 2010, 9:149 (2 June 2010)

Cost burdens are the product of complex relationships between social, economic and epidemiological factors. The cost data presented in this study reflect transmission patterns in the four districts, suggesting that a relationship between costs burdens and the nature of transmission might exist, and that the same warrants more attention from researchers and policy makers.

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Open Access | Malaria and Under-Nutrition: A Community Based Study Among Under-Five Children at Risk of Malaria, South-West Ethiopia

May 28, 2010 - 10:06 -- Kabogo Ndegwa
Author(s): 
Amare Deribew, Fessehaye Alemseged, Fasil Tessema, Lelisa Sena, Zewdie Birhanu, Ahmed Zeynudin, Morankar Sudhakar, Nasir Abdo, Kebede Deribe, Sibhatu Biadgilign
Reference: 
PLoS ONE 5(5): e10775.

In this study, there is no association between malaria and under-nutrition. Children who have malaria are more likely to be anaemic. Malaria prevention and control program should consider nutrition interventions particularly anemia.

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Synthetic glycosylphosphatidylinositol microarray reveals differential antibody levels and fine specificities in children with mild and severe malaria

May 28, 2010 - 09:47 -- Kabogo Ndegwa
Author(s): 
Marco Tamborrini, Xinyu Liu, Joseph Paschal Mugasa, Yong-Uk Kwon, Faustin Kamena, Peter H. Seeberger, Gerd Pluschke
Reference: 
Bioorganic & Medicinal Chemistry, Volume 18, Issue 11, 1 June 2010, Pages 3747-3752

Glycosylphosphatidylinositol (GPI) glycolipids abound on the cell surface at the merozoite stage of Plasmodium falciparum life cycle are a central toxin in malaria.

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Consequences of polyparasitism on anaemia among primary school children in Zimbabwe

May 25, 2010 - 08:55 -- Kabogo Ndegwa
Author(s): 
N. Midzi, S. Mtapuri-Zinyowera, M.P. Mapingure, D. Sangweme, M.T. Chirehwa, K.C. Brouwer, J. Mudzori, G. Hlerema, F. Mutapi, N. Kumar, T. Mduluza
Reference: 
Acta Tropica, Volume 115, Issues 1-2, July-August 2010, Pages 103-111

The effect of concomitant infection with schistosomes, Plasmodium falciparum and soil transmitted helminths (STHs) on anaemia was determined in 609 Zimbabwean primary school children.

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Open Access | Assessing bed net use and non-use after long-lasting insecticidal net distribution: a simple framework to guide programmatic strategies

May 19, 2010 - 09:33 -- Kabogo Ndegwa
Author(s): 
Vanden Eng JL, Thwing J, Wolkon A, Kulkarni MA, Manya A, Erskine M, Hightower A, Slutsker L
Reference: 
Malaria Journal 2010, 9:133 (18 May 2010)

The framework outlined in this paper provides a helpful tool to examine the deficiencies in ITN use. Monitoring and evaluation strategies designed to assess ITN ownership and use can easily incorporate this approach using existing data collection instruments that measure the standard indicators.

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Open Access | Alterations in early cytokine-mediated immune responses to Plasmodium falciparum infection in Tanzanian children with mineral element deficiencies: a cross-sectional survey

May 18, 2010 - 13:04 -- Kabogo Ndegwa
Author(s): 
Mbugi EV, Meijerink M, Veenemans J, Jeurink PV, McCall M, Olomi RM, Shao JF, Verhoef H, Savelkoul HF
Reference: 
Malaria Journal 2010, 9:130 (17 May 2010)

In view of these results, the findings show plasticity in cytokine profiles of mononuclear cells reacting to malaria infection under conditions of different micronutrient deficiencies.

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