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Open Access | Withholding Antimalarials in Febrile Children Who Have a Negative Result for a Rapid Diagnostic Test

August 6, 2010 - 08:30 -- Kabogo Ndegwa
Author(s): 
Valérie d’Acremont, Aggrey Malila, Ndeniria Swai, Robert Tillya, Judith Kahama‐Maro, Christian Lengeler, and Blaise Genton
Reference: 
Clinical Infectious Diseases 1 September 2010, Vol. 51, No. 5: 506-511

Not giving antimalarial drugs in febrile children who had a negative RDTm result was safe, even in an area highly endemic for malaria. Our study provides evidence for treatment recommendations based on parasitological diagnosis in children <5 years old.

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Open Access | Incidence of Malaria and Efficacy of Combination Antimalarial Therapies over 4 Years in an Urban Cohort of Ugandan Children

August 5, 2010 - 12:34 -- Kabogo Ndegwa
Author(s): 
Tamara D. Clark, Denise Njama-Meya, Bridget Nzarubara, Catherine Maiteki-Sebuguzi, Bryan Greenhouse, Sarah G. Staedke, Moses R. Kamya, Grant Dorsey, Philip J. Rosenthal
Reference: 
PLoS ONE 5(7): e11759

With ready access to combination therapies and distribution of ITNs, responses were excellent for artemisinin-containing regimens, severe malaria was not seen, and the incidence of malaria and prevalence of parasitemia and anemia decreased steadily over time.

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Open Access | Comparative field performance and adherence to test results of four malaria rapid diagnostic tests among febrile patients more than five years of age in Blantyre, Malawi

July 21, 2010 - 12:24 -- Kabogo Ndegwa
Author(s): 
Chinkhumba J, Skarbinski J, Chilima B, Campbell C, Ewing V, San Joaquin M, Sande J, Ali D, Mathanga D
Reference: 
Malaria Journal 2010, 9:209 (20 July 2010)

The results of this evaluation, combined with other published data and global recommendations, have been used to select RDTs for national scale-up. In addition, the study identified some key issues that need to be further delineated: the low field specificity of RDTs, variable RDT performance by different cadres of health workers and the need for a robust quality assurance system.

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Open Access | Principal component analysis of socioeconomic factors and their association with malaria in children from the Ashanti Region, Ghana

July 14, 2010 - 08:06 -- Kabogo Ndegwa
Author(s): 
Krefis A, Schwarz N, Nkrumah B, Acquah S, Loag W, Sarpong N, Adu-Sarkodie Y, Ranft U, May J
Reference: 
Malaria Journal 2010, 9:201 (13 July 2010)

The socioeconomic situation is significantly associated with malaria even in holoendemic rural areas where economic differences are not much pronounced. Valid classification of the socioeconomic level is crucial to be considered as confounder in intervention trials and in the planning of malaria control measures.

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Open Access | Estimating the Number of Paediatric Fevers Associated with Malaria Infection Presenting to Africa's Public Health Sector in 2007

July 8, 2010 - 07:58 -- Kabogo Ndegwa
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Author(s): 
Peter W. Gething, Viola C. Kirui, Victor A. Alegana, Emelda A. Okiro, Abdisalan M. Noor, Robert W. Snow
Reference: 
PLoS Med 7(7): e1000301

Spatial estimates of childhood fevers and care-seeking rates can be combined with a relational risk model of infection prevalence in the community to estimate the degree of parasitemia in those fevers reaching public health facilities.

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Open Access | The Platelet Count in Cerebral Malaria, Is It Useful to the Clinician?

July 2, 2010 - 10:19 -- Patrick Sampao
Author(s): 
Yamikani Chimalizeni, Kondwani Kawaza, Terrie Taylor, and Malcolm Molyneux
Reference: 
Am. J. Trop. Med. Hyg., 83(1), 2010, pp. 48-50

We studied children with cerebral malaria admitted to the pediatric research ward at Queen Elizabeth Central Hospital, Malawi. We analyzed 1,811 children with cerebral malaria and compared them with 521 children with bacterial meningitis.

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Open Access | Treatment choices for fevers in children under-five years in a rural Ghanaian district

June 29, 2010 - 12:35 -- Kabogo Ndegwa
Author(s): 
Nonvignon J, Aikins MK, Chinbuah MA, Abbey M, Gyapong M, Garshong BN, Fia S, Gyapong JO
Reference: 
Malaria Journal 2010, 9:188 (28 June 2010)

The results of this study imply that efforts at curbing under-five mortality due to malaria and pneumonia need to take into account care-seeking behaviour of caregivers of under-fives as well as implementation of strategies.

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Open Access | Sleeping arrangement and house structure affect bed net use in villages along Lake Victoria

June 24, 2010 - 09:42 -- Kabogo Ndegwa
Author(s): 
Iwashita H, Dida G, Futami K, Sonye G, Kaneko S, Horio M, Kawada H, Maekawa Y, Aoki Y, Minakawa N
Reference: 
Malaria Journal 2010, 9:176 (22 June 2010)

Net use was affected by sleeping arrangement and availability of suitable locations for hanging nets, in addition to net availability. Most residents had likely not realized that sleeping arrangement was a factor in net use. The ease of hanging a net is particularly important for children.

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Open Access | System effectiveness of a targeted free mass distribution of long lasting insecticidal nets in Zanzibar, Tanzania

June 22, 2010 - 10:19 -- Kabogo Ndegwa
Author(s): 
Beer N, Ali AS, de Savigny D, Al-mafazy AH, Ramsan M, Abass AK, Omari RS, Bjorkman A, Kallander K
Reference: 
Malaria Journal 2010, 9:173 (18 June 2010)

Targeted free mass distribution of LLINs can result in high and equitable bed net coverage among children under five. However, in order to sustain high effective coverage, there is need for complimentary distribution strategies between mass distribution campaigns.

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Open Access | Transforming Growth Factor Beta 2 and Heme Oxygenase 1 Genes Are Risk Factors for the Cerebral Malaria Syndrome in Angolan Children

June 18, 2010 - 11:23 -- Kabogo Ndegwa
Author(s): 
Maria Rosário Sambo, Maria Jesus Trovoada, Carla Benchimol, Vatúsia Quinhentos, Lígia Gonçalves, Rute Velosa, Maria Isabel Marques, Nuno Sepúlveda, Taane G. Clark, Stefan Mustafa, Oswald Wagner, António Coutinho, Carlos Penha-Gonçalves
Reference: 
PLoS ONE 5(6): e11141.

These results represent the first report on CM genetic risk factors in Angolan children and suggest the novel hypothesis that genetic variants of the TGFB2 and HMOX1 genes may contribute to confer a specific risk of developing the CM syndrome in patients with severe P. falciparum malaria.

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