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Open Access | Clinical Trials and Observations: High mortality from Plasmodium falciparum malaria in children living with sickle cell anemia on the coast of Kenya

September 10, 2010 - 13:29 -- Kabogo Ndegwa
Author(s): 
Charlotte F. McAuley, Clare Webb, Julie Makani, Alexander Macharia, Sophie Uyoga, Daniel H. Opi, Carolyne Ndila, Antony Ngatia, John Anthony G. Scott, Kevin Marsh, and Thomas N. Williams
Reference: 
Blood, 9 September 2010, Vol. 116, No. 10, pp. 1663-1668.

Although malaria is widely considered a major cause of death in young children born with sickle cell anemia (SCA) in sub-Saharan Africa, this is poorly quantified. We attempted to investigate this question through 4 large case-control analyses involving 7164 children living on the coast of Kenya.

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Open Access | Early clinical development of artemether-lumefantrine dispersible tablet: palatability of three flavours and bioavailability in healthy subjects

September 7, 2010 - 14:22 -- Kabogo Ndegwa
Author(s): 
Abdulla S, Amuri B, Kabanywanyi AM, Ubben D, Reynolds C, Pascoe S, Fitoussi S, Yeh C, Nuortti M, Sechaud R, Kaiser G, Lefevre G
Reference: 
Malaria Journal 2010, 9:253 (3 September 2010)

Considering that cherry was the preferred flavour, and that the novel A-L dispersible tablet demonstrated similar pharmacokinetic performances to the tablet administered crushed, a cherry-flavoured A-L dispersible tablet formulation was selected for further development and testing in a large efficacy and safety study in African children with malaria.

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Rapid Detection of Lactate Dehydrogenase and Genotyping of Plasmodium falciparum in Saliva of Children with Acute Uncomplicated Malaria

September 3, 2010 - 07:42 -- Patrick Sampao
Author(s): 
Grace O. Gbotosho, Christian T. Happi, Onikepe Folarin, Ochuko Keyamo, Akintunde Sowunmi, and Ayoade M. J. Oduola
Reference: 
Am. J. Trop. Med. Hyg., 83(3), 2010, pp. 496-501

Rapid detection of Plasmodium falciparum lactate dehydrogenase (pLDH) in saliva samples from 130 of 144 children with microscopically confirmed P. falciparum infection was evaluated using Optimal-IT dipsticks.

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Open Access | Malaria Incidence and Prevalence Among Children Living in a Peri-Urban Area on the Coast of Benin, West Africa: A Longitudinal Study

September 2, 2010 - 13:30 -- Patrick Sampao
Author(s): 
Alain N., Annette E., et al.
Reference: 
Am J Trop Med Hyg 2010 83: 465-473

Three cross-sectional surveys were also carried out. Malaria incidence showed a marked seasonal distribution with two peaks: the first corresponding to the long rainy season, and the second corresponding to the overflowing of Lake Nokoue.

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Evaluation of Recurrent Parasitemia after Artemether-Lumefantrine Treatment for Uncomplicated Malaria in Children in Western Kenya

September 2, 2010 - 13:16 -- Patrick Sampao
Author(s): 
Joseph V. Woodring, Bernhards Ogutu, David Schnabel, John N. Waitumbi, Cara H. Olsen, Douglas S. Walsh, D. Gray Heppner, Jr.,and Mark E. Polhemus
Reference: 
Am. J. Trop. Med. Hyg., 83(3), 2010, pp. 458-464

Although recrudescence in some cannot be ruled out, our cohort had a shorter median time to RP compared with other artemether-lumefantrine treatment studies.

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Open Access | Accuracy of an Immunochromatographic Diagnostic Test (ICT Malaria Combo Cassette Test) Compared to Microscopy among under Five-Year-Old Children when Diagnosing Malaria in Equatorial Guinea

August 25, 2010 - 14:49 -- Patrick Sampao
Author(s): 
José-Luis P., Maria R., et al.
Reference: 
Malaria Research and Treatment, Volume 2010 (2010)

The general results showed little concordance between the ICT test and microscopy (kappa = 0.28, se: 0.04). In Equatorial Guinea, the ICT Malaria Combo Cassette Test has proven to be an acceptable test to detect high P. falciparum parasitemias.

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Open Access | Cost Effectiveness of Seasonal Intermittent Preventive Treatment Using Amodiaquine & Artesunate or Sulphadoxine-Pyrimethamine in Ghanaian Children

August 20, 2010 - 12:07 -- Kabogo Ndegwa
Author(s): 
Lesong Conteh, Edith Patouillard, Margaret Kweku, Rosa Legood, Brian Greenwood, Daniel Chandramohan
Reference: 
PLoS ONE 5(8): e12223

We demonstrate how cost-effective IPTc is using three different drug regimens and the possibilities for reducing costs further if the intervention was to be scaled up to the district level. The need for effective training, drug delivery channels and supervision to support a strong network of community based volunteers is emphasised.

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Open Access | Combined measurement of soluble and cellular ICAM-1 among children with Plasmodium falciparum malaria in Uganda

August 18, 2010 - 12:39 -- Kabogo Ndegwa
Author(s): 
Cserti-Gazdewich CM, Dzik WH, Erdman L, Ssewanyana I, Dhabangi A, Musoke C, Kain KC
Reference: 
Malaria Journal 2010, 9:233 (16 August 2010)

In this cohort of children with P. falciparum malaria, sICAM-1 levels were associated with severity-of-illness. Patients with UM had higher monocyte ICAM-1 expression consistent with a role for monocyte ICAM-1 in immune clearance during non-severe malaria.

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Open Access | Retinopathy in severe malaria in Ghanaian children - overlap between fundus changes in cerebral and non-cerebral malaria

August 14, 2010 - 13:21 -- Patrick Sampao
Author(s): 
Essuman VA, Ntim-Amponsah CT, Astrup BS, Adjei GO, Kurtzhals JA, Ndanu TA, Goka B
Reference: 
Malaria Journal 2010, 9:232 (12 August 2010)

This study was designed to determine the diagnostic usefulness of retinopathy on ophthalmoscopy in severe malaria syndromes: Cerebral malaria (CM) and non-cerebral severe malaria (non-CM), i.e. malaria with respiratory distress (RD) and malaria with severe anaemia (SA), in Ghanaian children.

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Lumbar Puncture in Children from an Area of Malaria Endemicity Who Present with a Febrile Seizure

August 6, 2010 - 13:07 -- Kabogo Ndegwa
Author(s): 
Moses Laman, Laurens Manning, Ilomo Hwaiwhange, John Vince, Susan Aipit, Trevor Mare, Jonathan Warrel, Harin Karunajeewa, Peter Siba, Ivo Mueller, and Timothy M. E. Davis
Reference: 
Clinical Infectious Diseases 1 September 2010, Vol. 51, No. 5: 534-540

Initial LP is unnecessary when careful clinical assessment indicates features of a simple febrile seizure.

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