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children

The effects of a pre-season treatment with effective antimalarials on subsequent malaria morbidity in under five-year-old children living in high and seasonal malaria transmission area of Burkina Faso (pages 1315–1321)

October 22, 2010 - 09:37 -- Kabogo Ndegwa
Author(s): 
Alphonse Ouédraogo, Alfred B. Tiono, Amidou Diarra, Issa O. Nébié, Amadou T. Konaté and Sodiomon B. Sirima
Reference: 
Tropical Medicine & International Health, Volume 15, Issue 11, pages 1315–1321, November 2010

Our findings suggest that the radical clearance of parasitemia with AL may increase susceptibility to malaria infection and clinical malaria episodes.

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Pharmacology: Population Pharmacokinetics and Pharmacodynamics of Artemether and Lumefantrine during Combination Treatment in Children with Uncomplicated Falciparum Malaria in Tanzania

October 18, 2010 - 09:40 -- Patrick Sampao
Author(s): 
Sofia F., Andreas M., et al.
Reference: 
Antimicrob. Agents Chemother., Nov 2010; 54: 4780 - 4788.

The aim of this analysis was to describe the pharmacokinetics and pharmacodynamics of artemether, dihydroartemisinin, and lumefantrine in African children with uncomplicated malaria.

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Open Access | The humoral response to Plasmodium falciparum VarO rosetting variant and its association with protection against malaria in Beninese children

October 11, 2010 - 07:32 -- Kabogo Ndegwa
Author(s): 
Vigan-Womas I, Lokossou A, Guillotte M, Juillerat A, Bentley G, Garcia A, Mercereau-Puijalon O, Migot-Nabias F
Reference: 
Malaria Journal 2010, 9:267 (5 October 2010)

Children with severe and uncomplicated malaria had similar responses. The higher prevalence and level of VarO-reactive antibodies in asymptomatic children compared to children with malaria is consistent with a protective role for anti-VarO antibodies against clinical falciparum malaria.

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Brief Report: Increased Risk of Early Vomiting among Infants and Young Children Treated with Dihydroartemisinin-Piperaquine Compared with Artemether-Lumefantrine for Uncomplicated Malaria

October 4, 2010 - 12:25 -- Patrick Sampao
Author(s): 
Darren Creek, Victor Bigira, Emmanuel Arinaitwe, Humphrey Wanzira, Abel Kakuru, Jordan Tappero, Moses R. Kamya, Grant Dorsey, AND Taylor G. Sandison
Reference: 
Am J Trop Med Hyg, Oct 2010; 83: 873 - 875.

We used data from a randomized control trial in rural Uganda to compare the risk of early vomiting (within one hour of dosing) for children 6–24 months of age randomized to receive DP (n = 240) or AL (n = 228) for treatment of uncomplicated malaria.

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A Comparison of Iron and Folate with Folate Alone in Hematologic Recovery of Children Treated for Acute Malaria

October 4, 2010 - 11:44 -- Patrick Sampao
Author(s): 
Samuel N. Gara, Aboi J. K. Madaki, AND Tom D. Thacher
Reference: 
Am J Trop Med Hyg, Oct 2010; 83: 843 - 847.

We compared the effect of iron and folate with folate alone on hematologic recovery in children treated for acute malaria.

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Parasitology: PCR-Based Pooling of Dried Blood Spots for Detection of Malaria Parasites: Optimization and Application to a Cohort of Ugandan Children

October 1, 2010 - 08:57 -- Patrick Sampao
Author(s): 
Michelle S. Hsiang, Michael Lin, Christian Dokomajilar, Jordan Kemere, Christopher D. Pilcher, Grant Dorsey, and Bryan Greenhouse
Reference: 
J. Clin. Microbiol., Oct 2010; 48: 3539 - 3543.

We first used laboratory-prepared samples to compare 2 DNA extraction and 4 PCR detection methods across a range of pool sizes and parasite densities. Pooled Chelex extraction of DNA, followed by nested PCR of cytochrome b, was the optimal strategy, allowing reliable detection of a single low-parasitemic sample (100 parasites/µl) in pool sizes up to 50.

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Open Access | Community Case Management of Fever Due to Malaria and Pneumonia in Children Under Five in Zambia: A Cluster Randomized Controlled Trial

September 24, 2010 - 12:37 -- Kabogo Ndegwa
Author(s): 
Kojo Yeboah-Antwi, Portipher Pilingana, Davidson H Hamer, et al
Reference: 
PLoS Med 7(9): e1000340

The potential for CHWs to use RDTs, AL, and amoxicillin to manage both malaria and pneumonia at the community level is promising and might reduce overuse of AL, as well as provide early and appropriate treatment to children with nonsevere pneumonia.

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Open Access | The use of insecticide-treated nets for reducing malaria morbidity among children aged 6-59 months, in an area of high malaria transmission in central Cote d'Ivoire

September 24, 2010 - 09:36 -- Patrick Sampao
Author(s): 
Koudou BG, Ghattas H, Esse C, Nsanzabana C, Rohner F, Utzinger J, Faragher BE, Tschannen AB
Reference: 
Parasites & Vectors 2010, 3:91 (22 September 2010)

We carried out epidemiological analyses to investigate whether LLINs impact on Plasmodium prevalence rate and the proportion of clinically-confirmed malaria cases, in five villages in the district of Toumodi, central Cote d'Ivoire.

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Open Access | Impact of repeated four-monthly anthelmintic treatment on Plasmodium infection in preschool children: a double-blind placebo-controlled randomized trial

September 22, 2010 - 14:07 -- Patrick Sampao
Author(s): 
Kirwan P, Jackson AL, Asaolu SO, Molloy SF, Abiona TC, Bruce MC, Ranford-Cartwright L, O'Neill SM, Holland CV
Reference: 
BMC Infectious Diseases 2010, 10:277 (21 September 2010)

A double-blind placebo-controlled randomised trial was conducted to investigate the impact of anthelmintic treatment on Plasmodium infection in children aged 12-59 months.

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Short Communication: Comparison of artesunate and quinine in the treatment of Sudanese children with severe Plasmodium falciparum malaria

September 20, 2010 - 13:25 -- Patrick Sampao
Author(s): 
Hatim G. Eltahir, Abubaker A. Omer, Ayoub A. Mohamed, Ishag Adam
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 104, Issue 10, October 2010, Pages 684-686

Sixty-six children presenting to Singa hospital, Sudan with different manifestations of severe Plasmodium falciparum malaria were randomly divided into two well-matched groups (33 in each arm) to receive either intravenous artesunate 2•4 mg/kg at 0, 12, and 24 hours, then daily, or intravenous quinine 20 mg/kg initially then 10 mg/kg three times a day.

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