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Epistasis between the haptoglobin common variant and α+thalassemia influences risk of severe malaria in Kenyan children

April 1, 2014 - 09:43 -- Open Access
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Author(s): 
Sarah H. Atkinson, Sophie M. Uyoga, Emily Nyatichi, Alex W. Macharia, Gideon Nyutu, Carolyne Ndila, Dominic P. Kwiatkowski, Kirk A. Rockett, and Thomas N. Williams
Reference: 
Blood March 27, 2014 vol. 123 no. 13 2008-2016

Haptoglobin (Hp) scavenges free hemoglobin following malaria-induced hemolysis.

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Malaria: Review

February 23, 2014 - 11:07 -- Open Access
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Author(s): 
Nicholas J White, Sasithon Pukrittayakamee, Tran Tinh Hien, M Abul Faiz, Olugbenga A Mokuolu, Arjen M Dondorp
Reference: 
The Lancet, Volume 383, Issue 9918, 22–28 February 2014, Pages 723-735

We review the epidemiology, clinical features, pathology, prevention, and treatment of malaria.

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NOT Open Access | CD4+ T Cell Responses to the Plasmodium falciparum Erythrocyte Membrane Protein 1 in Children with Mild Malaria

February 14, 2014 - 08:32 -- NOT Open Access
Author(s): 
Evelyn N. Gitau, James Tuju, Henry Karanja, Liz Stevenson, Pilar Requena, Eva Kimani, Ally Olotu, Domtila Kimani, Kevin Marsh, Peter Bull, and Britta C. Urban
Reference: 
The Journal of Immunology February 15, 2014 vol. 192 no. 4 1753-1761

The immune response against the variant surface Ag Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a key component of clinical immunity against malaria.

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IFNγ/IL-10 Co-producing Cells Dominate the CD4 Response to Malaria in Highly Exposed Children

January 14, 2014 - 12:45 -- Open Access
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Author(s): 
Prasanna Jagannathan, Ijeoma Eccles-James, Margaret E. Feeney, et al.
Reference: 
PLoS Pathog 10(1): e1003864

Although evidence suggests that T cells are critical for immunity to malaria, reliable T cell correlates of exposure to and protection from malaria among children living in endemic areas are lacking.

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No asymptomatic malaria parasitaemia found among 108 young children at one health facility in Dar es Salaam, Tanzania

November 25, 2013 - 12:18 -- Open Access
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Author(s): 
Strøm GE, Tellevik MG, Fataki M, Langeland N, Blomberg B
Reference: 
Malaria Journal 2013, 12 :417 (14 November 2013)
MalariaWorld

The study suggests that asymptomatic malaria may not be present in apparently healthy children up to the age of three years in Dar es Salaam, Tanzania.

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Low prevalence of the molecular markers of Plasmodium falciparum resistance to chloroquine and sulphadoxine/pyrimethamine in asymptomatic children in northern Benin

November 25, 2013 - 08:52 -- Open Access
Author(s): 
Ogouyèmi-Hounto A, Ndam NT, Fadégnon G, Azagnandji C, Bello M, Moussiliou A, Chippaux J, Kinde Gazard D, Massougbodji A
Reference: 
Malaria Journal 2013, 12 :413 (13 November 2013)
MalariaWorld

This study showed a high diversity of P. falciparum in northern Benin with a very low prevalence of resistance markers to CQ and SP that dramatically contrasted with the pattern observed in southern Benin.

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Naturally Acquired Immune Responses to P. vivax Merozoite Surface Protein 3α and Merozoite Surface Protein 9 Are Associated with Reduced Risk of P. vivax Malaria in Young Papua New Guinean Children

November 19, 2013 - 12:42 -- Open Access
Author(s): 
Danielle I. Stanisic, Sarah Javati, Benson Kiniboro, Enmoore Lin, Jianlin Jiang, Balwan Singh, Esmeralda V. S. Meyer, Peter Siba, Cristian Koepfli, Ingrid Felger, Mary R. Galinski, Ivo Mueller
Reference: 
PLoS Negl Trop Dis 7(11): e2498
MalariaWorld

These results indicate that PvMSP3α Block II and PvMSP9 N-terminus should be further investigated for their potential as P. vivax vaccine antigens.

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Comparative safety of artemether-lumefantrine and other artemisinin-based combinations in children: a systematic review

November 7, 2013 - 07:07 -- Open Access
Author(s): 
Egunsola O, Oshikoya KA
Reference: 
Malaria Journal 2013, 12 :385 (1 November 2013)
MalariaWorld

Artemether-lumefantrine combination is as safe as ASAQ and DP for use in children.

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Plasma and Cerebrospinal Proteomes From Children With Cerebral Malaria Differ From Those of Children With Other Encephalopathies

October 3, 2013 - 18:00 -- Open Access
Author(s): 
Evelyn N. Gitau, Gilbert O. Kokwaro, Henry Karanja, Charles R. J. C. Newton and Stephen A. Ward
Reference: 
J Infect Dis. (2013) 208 (9): 1494-1503.
MalariaWorld

In particular, we report the expression of 2 spectrin proteins that have known Plasmodium falciparum–binding partners involved in the stability of the infected red blood cell, suppressing further invasion and possibly enhancing the red blood cell's ability to sequester in microvasculature.

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A High Force of Plasmodium vivax Blood-Stage Infection Drives the Rapid Acquisition of Immunity in Papua New Guinean Children

October 2, 2013 - 15:09 -- Open Access
Author(s): 
Cristian Koepfli, Kathryn L. Colborn, Benson Kiniboro, Enmoore Lin, Terence P. Speed, Peter M. Siba, Ingrid Felger, Ivo Mueller
Reference: 
PLoS Negl Trop Dis 7(9): e2403
MalariaWorld

P. vivax molFOB is considerably higher than P. falciparum molFOB (5.5 clones/child/year-at-risk).

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