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Population pharmacokinetics and pharmacodynamics of the artesunate–mefloquine fixed dose combination for the treatment of uncomplicated falciparum malaria in African children

April 22, 2019 - 12:28 -- Open Access
Author(s): 
Monia Guidi, Thomas Mercier, Manel Aouri, Laurent A. Decosterd, Chantal Csajka, Bernhards Ogutu, Gwénaëlle Carn and Jean-René Kiechel
Reference: 
Malaria Journal 2019 18:139, 18 April 2019

The population pharmacokinetic models developed for both AS/DHA and MQ showed a large variability in drug exposure in the investigated African paediatric population.

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Molecular epidemiology of residual Plasmodium vivax transmission in a paediatric cohort in Solomon Islands

March 28, 2019 - 16:34 -- Open Access
Author(s): 
Yi Wan Quah, Andreea Waltmann, Ivo Mueller, et al.
Reference: 
Malaria Journal 2019 18:106, 28 March 2019

Residual malaria transmission in Ngella exhibits strong heterogeneity and is characterized by a high proportion of submicroscopic and asymptomatic P. vivax infections, alongside sporadic P. falciparum infections.

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Seasonal malaria chemoprevention combined with community case management of malaria in children under 10 years of age, over 5 months, in south-east Senegal: A cluster-randomised trial

March 28, 2019 - 16:07 -- Open Access
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Author(s): 
Jean Louis A. Ndiaye, Youssoupha Ndiaye, Paul Milligan, et al.
Reference: 
PLoS Med 16(3): e1002762

 

In this study SMC for children under 10 years of age given over 5 months was feasible, well tolerated, and effective in preventing malaria episodes, and reduced the prevalence of parasitaemia and anaemia. SMC with CCM achieved high coverage and ensured children with malaria were promptly treated with artemether-lumefantrine.

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An update on glucose-6-phosphate dehydrogenase deficiency in children from Brazzaville, Republic of Congo

February 28, 2019 - 15:48 -- Open Access
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Author(s): 
Nerly Shirère Gampio Gueye, Simon Marie Peko, David Nderu, Felix Koukouikila-Koussounda, Christevy Vouvoungui, Simon Charles Kobawila, Thirumalaisamy P. Velavan and Francine Ntoumi
Reference: 
Malaria Journal 2019 18:57, 28 February 2019

This study gives an update on G6PD deficiency among Congolese children.

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Association of high Plasmodium falciparum parasite densities with polyclonal microscopic infections in asymptomatic children from Toubacouta, Senegal

February 26, 2019 - 15:20 -- Open Access
Author(s): 
Babacar Diouf, Fode Diop, Yakhya Dieye, Cheikh Loucoubar, Ibrahima Dia, Joseph Faye, Mbacké Sembène, Ronald Perraut, Makhtar Niang and Aïssatou Toure-Balde
Reference: 
Malaria Journal 2019 18:48, 21 February 2019

The strong genetic diversity of P. falciparum clones and the association of polyclonal infection with high parasitaemia call for a multi-allelic approach in the design of vaccine candidates for efficient malaria eradication.

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Relationship between weight status and anti-malarial drug efficacy and safety in children in Mali

February 19, 2019 - 14:29 -- Open Access
Author(s): 
Moussa Djimde, Hanen Samouda, Abdoulaye A. Djimde, et al.
Reference: 
Malaria Journal 2019 18:40, 18 February 2019

The findings suggest that weight deficiency has no deleterious effect on anti-malarial drug efficacy.

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The impact of early life exposure to Plasmodium falciparum on the development of naturally acquired immunity to malaria in young Malawian children

January 22, 2019 - 14:51 -- Open Access
Author(s): 
Priyanka Barua, James G. Beeson, Kenneth Maleta, Per Ashorn and Stephen J. Rogerson
Reference: 
Malaria Journal 2019 18:11, 18 January 2019

Antibodies to merozoite and IE surface antigens increased following infection in early childhood, but neither age at first infection nor number of malaria episodes substantially affected antibody acquisition.

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Caregiver responses and association with delayed care-seeking in children with uncomplicated and severe malaria

January 2, 2019 - 15:21 -- Open Access
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Author(s): 
Arthur Mpimbaza, Anne Katahoire, Philip J. Rosenthal, Charles Karamagi and Grace Ndeezi
Reference: 
Malaria Journal 2018 17:476, 18 December 2018

Caregivers should be educated on the importance of promptly seeking care at a health facility where appropriate care can be provided.

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Treatments used for malaria in young Ethiopian children: a retrospective study

December 6, 2018 - 16:43 -- Open Access
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Author(s): 
Abyot Endale Gurmu, Teresa Kisi, Habteweld Shibru, Bertrand Graz and Merlin Willcox
Reference: 
Malaria Journal 2018 17:451, 5 December 2018

In this study, only 30% of children took the recommended first-line treatment.

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Prevalence of inherited blood disorders and associations with malaria and anemia in Malawian children

November 21, 2018 - 15:24 -- Open Access
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Author(s): 
Patrick T. McGann, Anne M. Williams, Parminder S. Suchdev, et al.
Reference: 
Blood Advances 2018 2:3035-3044

In sub-Saharan Africa, inherited causes of anemia are common, but data are limited regarding the geographical prevalence and coinheritance of these conditions and their overall contributions to childhood anemia.

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