Not Open Access | Adherence and population pharmacokinetic properties of amodiaquine when used for seasonal malaria chemoprevention in African children
The developed methodology to evaluate adherence showed a sensitivity of 65‐71% when the first dose of SMC was directly observed and 71‐73% when no doses were observed in a routine programmatic setting. Adherence simulations and measured desethylamodiaquine concentrations in the case‐control children showed complete adherence (all doses taken) in less than 20% of children.