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Comment: Intermittent preventive treatment of malaria in infancy

November 13, 2009 - 10:40 -- Ingeborg van Schayk
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Author(s): 
Rose McGready
Reference: 
The Lancet, Volume 374, Issue 9700, 31 October 2009-6 November 2009, Pages 1478-1480

Looking to the future, and hoping that current downward trends in malaria are sustained, we need to evaluate the newly introduced antimalarials (piperaquine and pyronaridine look promising12) as well as mefloquine to assess whether and when is the best time to give IPT.

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Efficacy and safety of intermittent preventive treatment with sulfadoxine-pyrimethamine for malaria in African infants: a pooled analysis of six randomised, placebo-controlled trials

November 13, 2009 - 10:24 -- Ingeborg van Schayk
Author(s): 
John J Aponte et al.
Reference: 
The Lancet, Volume 374, Issue 9700, 31 October 2009-6 November 2009, Pages 1533-1542

Intermittent preventive treatment (IPT) is a promising strategy for previous termmalarianext term control in infants. We undertook a pooled analysis of the safety and efficacy of IPT in infants (IPTi) with sulfadoxine-pyrimethamine in Africa.

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Special Focus Review: From the circumsporozoite protein to the RTS,S/AS candidate vaccine

October 25, 2009 - 16:43 -- Ingeborg van Schayk
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Author(s): 
Joe Cohen, Victor Nussenzweig, Johan Vekemans and Amanda Leach
Reference: 
Human Vaccines, Volume 6, Issue 1, January 2010

The RTS,S/AS01E malaria vaccine candidate has recently entered phase 3 testing. Reaching this important milestone is the culmination of more than 20 years of research and development by GlaxoSmithKline and partners and collaborators. The vaccine has been developed to protect young children and infants living in sub-Saharan Africa against clinical and severe disease caused by Plasmodium falciparum infection.

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