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infant

Randomized, controlled trial of the long term safety, immunogenicity and efficacy of RTS,S/AS02D malaria vaccine in infants living in a malaria-endemic region

January 13, 2013 - 13:48 -- Open Access
Author(s): 
Abdulla S, Salim N, Tanner M, et al.
Reference: 
Malaria Journal 2013, 12:11 (8 January 2013)
MalariaWorld

Safety, immunogenicity and efficacy of the RTS,S/AS02D vaccine candidate when integrated into a standard EPI schedule for infants have been reported over a nine-month surveillance period. This paper describes results following 20 months of follow up.

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Open Access | Increase in EPI vaccines coverage after implementation of intermittent preventive treatment of malaria in infant with Sulfadoxine -pyrimethamine in the district of Kolokani, Mali: Results from a cluster randomized control trial

July 19, 2011 - 14:46 -- Patrick Sampao
Author(s): 
Alassane Dicko, Sidy O Toure, Ogobara K Doumbo, et al.
Reference: 
BMC Public Health 2011, 11:573

This study shows that high coverage of the IPTi can be obtained when the strategy is implemented using routine health services and implementation results in a significant increase in coverage of EPI vaccines in the district of Kolokani, Mali.

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Open Access | Therapeutics: Intermittent preventive treatment of infants with mefloquine reduces risk of clinical malaria in areas of moderate malaria transmission and high resistance to sulphadoxine-pyrimethamine

June 8, 2010 - 09:48 -- Kabogo Ndegwa
Author(s): 
R McGready
Reference: 
Evid Based Med (2010) 15: 71-2

Commentary on:

Gosling RD, Gesase S, Mosha JF, et al . Protective efficacy and safety of three antimalarial regimens for intermittent preventive treatment for malaria in infants: a randomised, double-blind, placebo-controlled trial. Lancet 2009;374:1521–32.

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Community Effectiveness of Intermittent Preventive Treatment for Infants (IPTi) in Rural Southern Tanzania

May 4, 2010 - 12:43 -- Patrick Sampao
Author(s): 
Joanna R. M. Armstrong Schellenberg, Kizito Shirima, Werner Maokola, Fatuma Manzi, Mwifadhi Mrisho, Adiel Mushi, Hassan Mshinda, Pedro Alonso, Marcel Tanner, and David M. Schellenberg
Reference: 
Am J Trop Med Hyg, May 2010; 82: 772 - 781.

Coverage and effects on malaria and anemia were estimated through a representative survey in 2006 with 600 children aged 2–11 months. Coverage of IPTi was 47–76% depending on the definition.

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Open Access | Intermittent preventive treatment in infants for the prevention of malaria in rural Western Kenya: a randomized, double-blind placebo-controlled trial

April 8, 2010 - 07:00 -- Kabogo Ndegwa
Author(s): 
FO Odhiambo, MJ Hamel, J Williamson, K Lindblade, FO ter Kuile, E Peterson, P Otieno, S Kariuki, J Vulule, L Slutsker, RD Newman
Reference: 
PLoS One (2010) 5: e10016.

IPTi with long-acting regimens provide protection against clinical malaria for up to 8 weeks even in the presence of high ITN coverage, and that the prophylactic rather than the treatment effect of IPTi appears central to its protective efficacy.

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Open Access | Duration of Protection Against Clinical Malaria Provided by Three Regimens of Intermittent Preventive Treatment in Tanzanian Infants

March 12, 2010 - 14:58 -- Ingeborg van Schayk
Tags: 
Author(s): 
Matthew Cairns, Roly Gosling, Ilona Carneiro, Samwel Gesase, Jacklin F. Mosha, Ramadhan Hashim, Harparkash Kaur, Martha Lemnge, Frank W. Mosha, Brian Greenwood, Daniel Chandramohan
Reference: 
PLoS ONE 5(3): e9467

Intermittent preventive treatment in infants (IPTi) is a new malaria control tool. This study investigated how protection against malaria given by SP, chlorproguanil-dapsone (CD) and mefloquine (MQ), varied with time since administration of IPTi.

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Open Access | Molecular markers of resistance to sulphadoxine-pyrimethamine one year after implementation of intermittent preventive treatment of malaria in infants in Mali

January 13, 2010 - 13:20 -- Ingeborg van Schayk
Author(s): 
Alassane Dicko, Issaka Sagara, Abdoulaye A Djimde, Sidy O Toure, Mariam Traore, Souleymane Dama, Abdoulbaki I Diallo, Amadou Barry, Mohamed Dicko, Oumar M Coulibaly, Christophe Rogier, Alexandra de Sousa, Ogobara K Doumbo
Reference: 
Malaria Journal 2010, 9:9 (10 January 2010)

A paper that addresses the issue of possible selection of drug resistant parasites in the context of Intermittent Preventive Treatment in infants. Importantly, this study evaluates the impact of the intervention at community level, in a context of a large scale implementation.

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Open Access | Malaria in infants below six months of age: retrospective surveillance of hospital admission records in Blantyre, Malawi

January 7, 2010 - 13:08 -- Ingeborg van Schayk
Author(s): 
Beatriz Larru, Elizabeth Molyneux, Feiko O ter Kuile, Terrie Taylor, Malcolm Molyneux, Dianne J Terlouw
Reference: 
Malaria Journal 2009, 8:310 (29 December 2009)

The World Health Organization provides treatment guidelines for children from six months onwards, without specific treatment guidelines for the younger infants. A number of recent reports however suggest that the burden in this young age group may be underestimated.

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Protective efficacy and safety of three antimalarial regimens for intermittent preventive treatment for malaria in infants: a randomised, double-blind, placebo-controlled trial

November 27, 2009 - 14:30 -- Ingeborg van Schayk
Author(s): 
Roly Gosling , Samwel Gesase, Jacklin Mosha, Ilona Carneiro, Ramadhan Hashim, Martha Lemnge, Frank Mosha , Brian Greenwood, Daniel Chandramohan
Reference: 
The Lancet, Volume 374, Issue 9700, Pages 1521 - 1532, 31 October 2009, doi:10.1016/S0140-6736(09)60997-1

Administration of sulfadoxine-pyrimethamine at times of vaccination—intermittent preventive treatment in infants (IPTi)—is a promising strategy to prevent malaria. However, rising resistance to this combination is a concern. We investigated a shortacting and longacting antimalarial drug as alternative regimens for IPTi.

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Society Meeting Paper: Mode of action and choice of antimalarial drugs for intermittent preventive treatment in infants

November 26, 2009 - 07:26 -- Kabogo Ndegwa
Author(s): 
Matthew Cairns, Roly Gosling, Samwel Gesase, Jacklin Mosha, Brian Greenwood, Daniel Chandramohan
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 103, Issue 12, December 2009, Pages 1199-1201, doi:10.1016/j.trstmh.2009.06.007

Intermittent preventive treatment in infants (IPTi) is an effective and safe malaria control strategy. However, it remains unclear what antimalarials should be used to replace sulfadoxine-pyrimethamine (SP) when and where SP is no longer an effective drug for IPTi.

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