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Review | Of mice and women: rodent models of placental malaria

July 22, 2010 - 09:16 -- Patrick Sampao
Author(s): 
Lars Hviid, Claudio R.F. Marinho, Trine Staalsoe, Carlos Penha-Gonçalves
Reference: 
Trends in Parasitology, Volume 26, Issue 8, August 2010, Pages 412-419

Placental IE sequestration in the intervillous space is mediated by variant surface antigens (VSAs) selectively expressed in placental malaria (PM) and specific for chondroitin sulfate A (CSA). In Plasmodium falciparum, these VSAPM appear largely synonymous with the P. falciparum erythrocyte membrane protein 1 (PfEMP1) family variant VAR2CSA.

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Intermittent preventive treatment of malaria in pregnancy (IPTp): do frequent antenatal care visits ensure access and compliance to IPTp in Ugandan rural communities?

July 13, 2010 - 06:56 -- Patrick Sampao
Author(s): 
Richard Ndyomugyenyi, James Katamanywa
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 104, Issue 8, August 2010, Pages 536-540

The relationship between antenatal care (ANC) visits and coverage of intermittent preventive treatment of malaria in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP), and barriers to IPTp-SP access were examined.

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Open Access | Plasmodium falciparum population dynamics in a cohort of pregnant women in Senegal

June 18, 2010 - 11:37 -- Kabogo Ndegwa
Author(s): 
Guitard J, Andersen P, Ermont C, Gnidehou S, Fievet N, Lund O, Deloron P, Tuikue Ndam N
Reference: 
Malaria Journal 2010, 9:165 (16 June 2010)

Host immunity to VAR2CSA influences the parasite dynamics during pregnancy, suggesting that the acquisition of protective immunity requires pre-exposure to a limited number of parasite variants.

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Evaluation of the Antigenic Diversity of Placenta-Binding Plasmodium falciparum Variants and the Antibody Repertoire among Pregnant Women.

May 18, 2010 - 13:07 -- Patrick Sampao
Author(s): 
Mirja H., Salenna R. E., et al.
Reference: 
Infection and Immunity, May 2010, p. 1963-1978, Vol. 78, No. 5

The results indicate that there is limited antigenic diversity in placenta-binding isolates and may explain why immunity to malaria in pregnancy can be achieved after exposure during one pregnancy.

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Evaluation of the Antigenic Diversity of Placenta-Binding Plasmodium falciparum Variants and the Antibody Repertoire among Pregnant Women

April 19, 2010 - 14:42 -- Patrick Sampao
Author(s): 
Mirja H., Salenna R. E., et al
Reference: 
Infection and Immunity, p. 1963-1978, Vol. 78, No. 5 May 2010

The results indicate that there is limited antigenic diversity in placenta-binding isolates and may explain why immunity to malaria in pregnancy can be achieved after exposure during one pregnancy.

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Malaria and stillbirth in Omdurman Maternity Hospital, Sudan

April 13, 2010 - 09:39 -- Patrick Sampao
Author(s): 
Elshiekh Bader, Amel M. Alhaj, Ahmed A. Hussan, Ishag Adam
Reference: 
International Journal of Gynecology & Obstetrics, Volume 109, Issue 2, May 2010, Pages 144-146

A case-control study: Cases were women who delivered stillbirths; 2 consecutive women who delivered a live-born singleton neonate at term (37–42 weeks) per case were used as controls.

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Open Access | Women's experiences and views about costs of seeking malaria chemoprevention and other antenatal services: a qualitative study from two districts in rural Tanzania

February 17, 2010 - 20:40 -- Ingeborg van Schayk
Author(s): 
Godfrey M Mubyazi, Paul Bloch, Pascal Magnussen, Oystein E Olsen, Jens Byskov, Kristian S Hansen, Ib C Bygbjerg
Reference: 
Malaria Journal 2010, 9:54 (17 February 2010)

The authors feel that although the Tanzanian government recommends that women who attend antenatal care clinics also receive intermittent preventive treatment against malaria and vouchers for insecticide-treated nets at subsidized prices, the effectiveness of this policy has never been tested in the field.

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Open Access | Plasmodium falciparum Infection Significantly Impairs Placental Cytokine Profile in HIV Infected Cameroonian Women

December 15, 2009 - 21:00 -- Ingeborg van Schayk
Author(s): 
Kfutwah A, Mary JY, Lemen B, Leke R, Rousset D, et al.
Reference: 
PLoS ONE 4(12): e8114

These results show that P. falciparum infection profoundly modifies the placenta cytokine environment and acts as a confounding factor, masking the impact of HIV-1 in co-infected women.

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Open Access | Opinion: Hidden burden of malaria in Indian women

December 14, 2009 - 11:25 -- Ingeborg van Schayk
Author(s): 
Vinod P Sharma
Reference: 
Malaria Journal 2009, 8:281 (8 December 2009)

Inadequate surveillance and gross under-reporting has been highlighted time and again for over three decades. As a result the huge problem of malaria in pregnancy reported occasionally by researchers has remained hidden.

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Guidelines and considerations for testing malaria vaccines in pregnant women

October 25, 2009 - 16:20 -- Ingeborg van Schayk
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Author(s): 
Clara Menendez and Pedro Alonso
Reference: 
Human Vaccines, Volume 6, Issue 1, January 2010

Important progress has been made in the last years especially in sub-Saharan Africa, with the introduction of strategies to prevent malaria in pregnancy consisting of intermittent preventive treatment and insecticide treated nets. However, their coverage is still unacceptably low and malaria continues to demand a huge toll on pregnant women and their newborns. Thus, there is a need to explore other preventive strategies such as a vaccine against malaria, which combined with the current tools would maximise the protection efficacy.

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