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pregnant women

Intermittent screening and treatment with artemether–lumefantrine versus intermittent preventive treatment with sulfadoxine–pyrimethamine for malaria in pregnancy: a facility-based, open-label, non-inferiority trial in Nigeria

July 6, 2018 - 16:52 -- Open Access
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Author(s): 
Ekpereonne Esu, Nicole Berens-Riha, Michael Pritsch, Nuria Nwachuku, Thomas Loescher and Martin Meremikwu
Reference: 
Malaria Journal 2018 17:251, 6 July 2018

The trial results suggest that in an area of high malaria transmission with moderate sulfadoxine–pyrimethamine resistance, ISTp with artemether–lumefantrine may be an effective strategy for controlling malaria in pregnancy.

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Artemether-lumefantrine dosing for malaria treatment in young children and pregnant women: A pharmacokinetic-pharmacodynamic meta-analysis

June 21, 2018 - 17:12 -- Open Access
Author(s): 
Frank Kloprogge, Lesley Workman, Joel Tarning, et al.
Reference: 
PLoS Med 15(6): e1002579

Our findings suggest that revised AL dosing regimens for young children and pregnant women would improve drug exposure but would require longer or more complex schedules.

Medical Treatment: 

Association between timing and number of antenatal care visits on uptake of intermittent preventive treatment for malaria during pregnancy among Malawian women

May 29, 2018 - 14:40 -- Open Access
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Author(s): 
Owen Nkoka, Ting-Wu Chuang and Yi-Hua Chen
Reference: 
Malaria Journal 2018 17:211, 25 May 2018

ANC attendance is vital in IPTp uptake.

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Prevention and treatment of malaria in pregnancy: what do pregnant women and health care workers in East India know and do about it?

May 22, 2018 - 14:01 -- Open Access
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Author(s): 
Lora Sabin, Evan M. S. Hecht, Davidson H. Hamer, et al.
Reference: 
Malaria Journal 2018 17:207, 18 May 2018

Understanding of malaria varied as a concern for pregnant women, continued use of unproven malaria prevention and treatment strategies was evident in this population in India.

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IgM and IgG against Plasmodium falciparum lysate as surrogates of malaria exposure and protection during pregnancy

May 15, 2018 - 14:34 -- Open Access
Author(s): 
Alfredo Mayor, Carlota Dobaño, Pedro L. Alonso, et al.
Reference: 
Malaria Journal 2018 17:182, 10 May 2018

Adjusting the analysis for the simultaneous effect of IgMs and IgGs can contribute to account for heterogeneous exposure to P. falciparum when assessing immune responses effective against malaria in pregnancy.

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Malaria-related ideational factors and other correlates associated with intermittent preventive treatment among pregnant women in Madagascar

April 25, 2018 - 15:20 -- Open Access
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Author(s): 
Grace N. Awantang, Stella O. Babalola, Hannah Koenker, Kathleen A. Fox, Michael Toso and Nan Lewicky
Reference: 
Malaria Journal 2018 17:176, 25 April 2018

Health communication programmes should aim to improve IPTp/ANC-specific ideation, particularly the norms of seeking regular care during pregnancy and taking any prescribed medication.

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Risk factors and pregnancy outcomes associated with placental malaria in a prospective cohort of Papua New Guinean women

October 30, 2017 - 14:55 -- Open Access
Author(s): 
Elvin Lufele, Alexandra Umbers, Stephen Rogerson, et al.
Reference: 
Malaria Journal 2017 16:427, 24 October 2017

Among pregnant PNG women receiving at least one dose of intermittent preventive treatment in pregnancy and using insecticide-treated bed nets, active PM infections were associated with adverse outcomes.

NOT Open Access | Optimal antimalarial dose regimens for chloroquine in pregnancy based on population pharmacokinetic modelling

October 12, 2017 - 15:14 -- NOT Open Access
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Author(s): 
Sam Salman, Francesca Baiwog, Timothy M.E. Davis, et al.
Reference: 
International Journal of Antimicrobial Agents, Volume 50, Issue 4, October 2017, Pages 542-551

Despite extensive use and accumulated evidence of safety, there have been few pharmacokinetic studies from which appropriate chloroquine (CQ) dosing regimens could be developed specifically for pregnant women.

Medical Treatment: 

Malaria, malnutrition, and birthweight: A meta-analysis using individual participant data

August 10, 2017 - 15:37 -- Open Access
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Author(s): 
Jordan E. Cates, Holger W. Unger, Stephen Rogerson, et al.
Reference: 
PLoS Med 14(8): e1002373

Pregnant women with malnutrition and malaria infection are at increased risk of LBW compared to women with only 1 risk factor or none, but malaria and malnutrition do not act synergistically.

NOT Open Access | Dihydroartemisinin-piperaquine versus artesunate-amodiaquine for treatment of malaria infection in pregnancy in Ghana: an open-label, randomised, non-inferiority trial

August 10, 2017 - 15:14 -- NOT Open Access
Author(s): 
Joseph Osarfo, Harry Tagbor, Matthew Cairns, Michael Alifrangis and Pascal Magnussen
Reference: 
Tropical Medicine & International Health, Volume 22, Issue 8 August 2017, Pages 1043–1052

DHA-PPQ was non-inferior to ASAQ for treatment of malaria infection during pregnancy.

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