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pregnant women

Health system, socio-cultural, economic, environmental and individual factors influencing bed net use in the prevention of malaria in pregnancy in two Ghanaian regions

November 19, 2019 - 06:09 -- Open Access
Author(s): 
Matilda Aberese-Ako, Pascal Magnussen, Gifty D. Ampofo and Harry Tagbor
Reference: 
Malaria Journal 2019 18:363, 12 November 2019

Improving maternal health remains a priority to the Ghanaian government. Consequently, it has implemented the World Health Organization recommendation of distributing free long-lasting insecticidal nets (LLINs) to pregnant women—one of the effective strategies to combating malaria in pregnancy. However, the burden of negative outcomes of malaria in pregnancy such as low birth weight and miscarriages is still high. This may be related to the health system, socio-cultural and economic dynamics that influence LLIN use, but their role is not well understood. This ethnographic study sought to understand health system, socio-cultural, economic and environmental dynamics in utilization of LLINs among pregnant women in two Ghanaian regions.

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Microscopic and submicroscopic Plasmodium falciparum infection, maternal anaemia and adverse pregnancy outcomes in Papua New Guinea: a cohort study

September 10, 2019 - 15:24 -- Open Access
Author(s): 
Holger W. Unger, Anna Rosanas-Urgell, Leanne J. Robinson, Maria Ome-Kaius, Shadrach Jally, Alexandra J. Umbers, Willie Pomat, Ivo Mueller, Eline Kattenberg and Stephen J. Rogerson
Reference: 
Malaria Journal 2019 18:302, 2 September 2019

Infection during pregnancy with Plasmodium falciparum is associated with maternal anaemia and adverse birth outcomes including low birth weight (LBW). Studies using polymerase chain reaction (PCR) techniques indicate that at least half of all infections in maternal venous blood are missed by light microscopy or rapid diagnostic tests. The impact of these subpatent infections on maternal and birth outcomes remains unclear.

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Intermittent screening and treatment with dihydroartemisinin-piperaquine and intermittent preventive therapy with sulfadoxine-pyrimethamine have similar effects on malaria antibody in pregnant Malawian women

June 7, 2019 - 16:56 -- Open Access
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Author(s): 
Andrew Teo, Louise M. Randall, Stephen J. Rogerson, et al.
Reference: 
Scientific Reports 9, Article number: 7878 (2019)

In a randomised trial comparing intermittent screening and treatment (IST) with dihydroartemisinin-piperaquine (DP) and intermittent preventive therapy against malaria in pregnancy (IPT) with sulfadoxine-pyrimethamine (SP) in Malawi, the impacts of IST-DP and IPT-SP on the development and maintenance of malaria antibody immunity were compared.

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Excess risk of preterm birth with periconceptional iron supplementation in a malaria endemic area: analysis of secondary data on birth outcomes in a double blind randomized controlled safety trial in Burkina Faso

May 7, 2019 - 13:56 -- Open Access
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Author(s): 
Bernard Brabin, Sabine Gies, Stephen A. Roberts, Salou Diallo, Olga M. Lompo, Adama Kazienga, Loretta Brabin, Sayouba Ouedraogo and Halidou Tinto
Reference: 
Malaria Journal 2019 18:161, 6 May 2019

Iron supplementation before a first pregnancy may improve the future health of mother and baby by reducing maternal anaemia. Iron supplementation could, however, increase malaria infections, notably in primigravidae who are most susceptible. The pathogenicity of other iron-utilizing pathogens could also increase, causing inflammation leading to increased risk of adverse birth outcomes. This paper reports pre-specified secondary birth outcomes from a safety trial in Burkina Faso in an area of high malaria endemicity. Primary outcomes from that trial had investigated effects of long-term weekly iron supplementation on malaria and genital tract infections in non-pregnant and pregnant women.

Artemisinin-based combination therapy during pregnancy: outcome of pregnancy and infant mortality: a cohort study

March 28, 2019 - 16:32 -- Open Access
Tags: 
Author(s): 
Michael Nambozi, Halidou Tinto, Umberto D’Alessandro, et al.
Reference: 
Malaria Journal 2019 18:105, 28 March 2019

Outcome of pregnancy and infant survival were similar between treatment arms indicating that any of the four artemisinin-based combinations could be safely used during the second and third trimester of pregnancy without any adverse effect on the baby.

NOT Open Access | Malaria in pregnancy shapes the development of foetal and infant immunity

March 6, 2019 - 13:22 -- NOT Open Access
Author(s): 
Whitney E. Harrington, Abel Kakuru, Prasanna Jagannathan
Reference: 
Parasitic Infection and Maternal Immunity Volume41, Issue3 March 2019 e12573

Malaria, particularly Plasmodium falciparum, continues to disproportionately affect pregnant women.

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NOT Open Access | Population Pharmacokinetics of Mefloquine Intermittent Preventive Treatment for Malaria in Pregnancy in Gabon

February 6, 2019 - 15:24 -- NOT Open Access
Tags: 
Author(s): 
Michael Ramharter, Matthias Schwab, Thorsten Lehr, et al.
Reference: 
Antimicrob. Agents Chemother. January 2019 63:e01113-18

Mefloquine was evaluated as an alternative for intermittent preventive treatment of malaria in pregnancy (IPTp) due to increasing resistance against the first-line drug sulfadoxine-pyrimethamine (SP).

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Has doxycycline, in combination with anti-malarial drugs, a role to play in intermittent preventive treatment of Plasmodium falciparum malaria infection in pregnant women in Africa?

December 27, 2018 - 15:22 -- Open Access
Author(s): 
Tiphaine Gaillard, Manon Boxberger, Marylin Madamet and Bruno Pradines
Reference: 
Malaria Journal 2018 17:469, 14 December 2018

According to the World Health Organization (WHO), Plasmodium falciparum malaria during pregnancy is responsible for deleterious consequences for the mother and her child.

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An analysis of country adoption and implementation of the 2012 WHO recommendations for intermittent preventive treatment for pregnant women in sub-Saharan Africa

October 17, 2018 - 15:13 -- Open Access
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Author(s): 
Marianne Henry, Lia Florey, Susan Youll and Julie R. Gutman
Reference: 
Malaria Journal 2018 17:364, 16 October 2018

Overall, coverage of both IPTp2+ and IPTp3+ has improved in recent years.

Prevalence of Plasmodium falciparum infection among pregnant women at first antenatal visit in post-Ebola Monrovia, Liberia

October 17, 2018 - 14:58 -- Open Access
Author(s): 
Guillermo Martínez-Pérez, Dawoh Peter Lansana, Alfredo Mayor, et al.
Reference: 
Malaria Journal 2018 17:357, 11 October 2018

Plasmodium falciparum infections are expected to occur in at least one in every eight women attending first ANC at private clinics in Monrovia and outside the peak of the rainy season.

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