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pregnant women

NOT Open Access | Population Pharmacokinetics of Mefloquine Intermittent Preventive Treatment for Malaria in Pregnancy in Gabon

February 6, 2019 - 15:24 -- NOT Open Access
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Author(s): 
Michael Ramharter, Matthias Schwab, Thorsten Lehr, et al.
Reference: 
Antimicrob. Agents Chemother. January 2019 63:e01113-18

Mefloquine was evaluated as an alternative for intermittent preventive treatment of malaria in pregnancy (IPTp) due to increasing resistance against the first-line drug sulfadoxine-pyrimethamine (SP).

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Has doxycycline, in combination with anti-malarial drugs, a role to play in intermittent preventive treatment of Plasmodium falciparum malaria infection in pregnant women in Africa?

December 27, 2018 - 15:22 -- Open Access
Author(s): 
Tiphaine Gaillard, Manon Boxberger, Marylin Madamet and Bruno Pradines
Reference: 
Malaria Journal 2018 17:469, 14 December 2018

According to the World Health Organization (WHO), Plasmodium falciparum malaria during pregnancy is responsible for deleterious consequences for the mother and her child.

Continent: 

An analysis of country adoption and implementation of the 2012 WHO recommendations for intermittent preventive treatment for pregnant women in sub-Saharan Africa

October 17, 2018 - 15:13 -- Open Access
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Author(s): 
Marianne Henry, Lia Florey, Susan Youll and Julie R. Gutman
Reference: 
Malaria Journal 2018 17:364, 16 October 2018

Overall, coverage of both IPTp2+ and IPTp3+ has improved in recent years.

Prevalence of Plasmodium falciparum infection among pregnant women at first antenatal visit in post-Ebola Monrovia, Liberia

October 17, 2018 - 14:58 -- Open Access
Author(s): 
Guillermo Martínez-Pérez, Dawoh Peter Lansana, Alfredo Mayor, et al.
Reference: 
Malaria Journal 2018 17:357, 11 October 2018

Plasmodium falciparum infections are expected to occur in at least one in every eight women attending first ANC at private clinics in Monrovia and outside the peak of the rainy season.

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Intermittent screening and treatment with artemether–lumefantrine versus intermittent preventive treatment with sulfadoxine–pyrimethamine for malaria in pregnancy: a facility-based, open-label, non-inferiority trial in Nigeria

July 6, 2018 - 16:52 -- Open Access
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Author(s): 
Ekpereonne Esu, Nicole Berens-Riha, Michael Pritsch, Nuria Nwachuku, Thomas Loescher and Martin Meremikwu
Reference: 
Malaria Journal 2018 17:251, 6 July 2018

The trial results suggest that in an area of high malaria transmission with moderate sulfadoxine–pyrimethamine resistance, ISTp with artemether–lumefantrine may be an effective strategy for controlling malaria in pregnancy.

Medical Treatment: 

Artemether-lumefantrine dosing for malaria treatment in young children and pregnant women: A pharmacokinetic-pharmacodynamic meta-analysis

June 21, 2018 - 17:12 -- Open Access
Author(s): 
Frank Kloprogge, Lesley Workman, Joel Tarning, et al.
Reference: 
PLoS Med 15(6): e1002579

Our findings suggest that revised AL dosing regimens for young children and pregnant women would improve drug exposure but would require longer or more complex schedules.

Medical Treatment: 

Association between timing and number of antenatal care visits on uptake of intermittent preventive treatment for malaria during pregnancy among Malawian women

May 29, 2018 - 14:40 -- Open Access
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Author(s): 
Owen Nkoka, Ting-Wu Chuang and Yi-Hua Chen
Reference: 
Malaria Journal 2018 17:211, 25 May 2018

ANC attendance is vital in IPTp uptake.

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Prevention and treatment of malaria in pregnancy: what do pregnant women and health care workers in East India know and do about it?

May 22, 2018 - 14:01 -- Open Access
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Author(s): 
Lora Sabin, Evan M. S. Hecht, Davidson H. Hamer, et al.
Reference: 
Malaria Journal 2018 17:207, 18 May 2018

Understanding of malaria varied as a concern for pregnant women, continued use of unproven malaria prevention and treatment strategies was evident in this population in India.

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IgM and IgG against Plasmodium falciparum lysate as surrogates of malaria exposure and protection during pregnancy

May 15, 2018 - 14:34 -- Open Access
Author(s): 
Alfredo Mayor, Carlota Dobaño, Pedro L. Alonso, et al.
Reference: 
Malaria Journal 2018 17:182, 10 May 2018

Adjusting the analysis for the simultaneous effect of IgMs and IgGs can contribute to account for heterogeneous exposure to P. falciparum when assessing immune responses effective against malaria in pregnancy.

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Malaria-related ideational factors and other correlates associated with intermittent preventive treatment among pregnant women in Madagascar

April 25, 2018 - 15:20 -- Open Access
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Author(s): 
Grace N. Awantang, Stella O. Babalola, Hannah Koenker, Kathleen A. Fox, Michael Toso and Nan Lewicky
Reference: 
Malaria Journal 2018 17:176, 25 April 2018

Health communication programmes should aim to improve IPTp/ANC-specific ideation, particularly the norms of seeking regular care during pregnancy and taking any prescribed medication.

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