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Not Open Access | Pharmacokinetic Properties and Bioequivalence of Two Sulfadoxine/Pyrimethamine Fixed-Dose Combination Tablets: A Parallel-Design Study in Healthy Chinese Male Volunteers

November 12, 2012 - 16:13 -- NOT Open Access
Author(s): 
Yan-Mei Liu, Kanyin E. Zhang, Chen Yu, et al.
Reference: 
Clinical Therapeutics, Volume 34, Issue 11, November 2012, Pages 2212-2220

MalariaWorldThe aim of the present study was to compare the pharmacokinetic profiles between a new generic and the branded reference formulation of sulfadoxine/pyrimethamine FDC tablets, and to assess the bioequivalence of the 2 products in healthy Chinese volunteers.

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Not Open Access | Population pharmacokinetics of halofantrine in healthy volunteers and patients with symptomatic falciparum malaria

October 16, 2012 - 16:45 -- Patrick Sampao
Author(s): 
Klein K, Aarons L, Ter Kuile FO, Nosten F, White NJ, Edstein MD, Teja-Isavadharm P.
Reference: 
J Pharm Pharmacol. 2012 Nov;64(11):1603-1613

MalariaWorldTo investigate the population pharmacokinetics of the antimalarial halofantrine (HF) in healthy volunteers and patients with symptomatic falciparum malaria.

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Not Open Access | Low-Level Plasmodium falciparum Blood-Stage Infection Causes Dendritic Cell Apoptosis and Dysfunction in Healthy Volunteers

July 12, 2012 - 07:45 -- Patrick Sampao
Author(s): 
Tonia Woodberry, Gabriela Minigo, Kim A. Piera, Fiona H. Amante, Alberto Pinzon-Charry, Michael F. Good, J. Alejandro Lopez, Christian R. Engwerda, James S. McCarthy and Nicholas M. Anstey
Reference: 
J Infect Dis. (2012) 206 (3): 333-340

MalariaWorldThese findings may explain in part the inadequate development of immunity to blood-stage malaria infection.

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Open Access | Drug-Drug Interaction Analysis of Pyronaridine/Artesunate and Ritonavir in Healthy Volunteers

March 9, 2012 - 14:36 -- Patrick Sampao
Author(s): 
Carrie A. Morris, Luis Lopez-Lazaro, Donald Jung, Janthima Methaneethorn, Stephan Duparc, Isabelle Borghini-Fuhrer, Rolf Pokorny, Chang-Sik Shin and Lawrence Fleckenstein
Reference: 
Am J Trop Med Hyg 2012 vol. 86 no. 3 489-495

MalariaWorldA multiple dose, parallel group study was conducted to assess for a drug-drug interaction between the pyronaridine/artesunate (PA) combination antimalarial and ritonavir.

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Pharmacokinetics and Ex Vivo Antimalarial Activity of Artesunate-Azithromycin in Healthy Volunteers

August 18, 2011 - 14:58 -- Patrick Sampao
Author(s): 
Nguyen Trong Chinh, Nguyen Ngoc Quang, Michael D. Edstein, et al.
Reference: 
Antimicrobial Agents and Chemotherapy, September 2011,p. 4412-4415, Vol. 55, No. 9

In 18 male healthy subjects, artesunate (200 mg)-azithromycin (1,500 mg) daily for 3 days was found to be well tolerated, with only mild gastrointestinal disturbances reported.

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Consistent safety and infectivity in sporozoite challenge model of Plasmodium vivax in malaria-naive human volunteers.

February 17, 2011 - 14:05 -- Patrick Sampao
Author(s): 
Herrera S, Solarte Y, Jordán-Villegas A, Echavarría JF, Rocha L, Palacios R, Ramírez O, Vélez JD, Epstein JE, Richie TL, Arévalo-Herrera M.
Reference: 
Am J Trop Med Hyg. 2011 Feb;84(2 Suppl):4-11.

Clinical manifestations of malaria and parasitemia were monitored beginning 7 days post-challenge. All Duffy (+) volunteers developed patent malaria infection within 16 days after challenge.

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