The data reported here begins to clarify the functional domains of the P. knowlesi RBLs. A binding domain has been identified and characterized in PkNBPXb. Notably, this study demonstrates that unlike PkNBPXb, PkNBPXa can bind to human erythrocytes, suggesting that PkNBPXa may function as a ligand to enable the invasion of P. knowlesi merozoites into human cells.
Malaria Journal 2012, 11:228 (6 July 2012)
Malaria Journal 2010, 9(Suppl 2):I2 (20 October 2010)
Despite prolonged and intense effort to understand and control the health impact of malaria morbidity and mortality, malaria remains third in the global ranking for severe and fatal infections.