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Two functional reticulocyte binding-like (RBL) invasion ligands of zoonotic Plasmodium knowlesi exhibit differential adhesion to monkey and human erythrocytes

July 13, 2012 - 10:48 -- Patrick Sampao
Author(s): 
Semenya AA, Tran TM, Meyer EV, Barnwell JW, Galinski MR
Reference: 
Malaria Journal 2012, 11:228 (6 July 2012)

MalariaWorldThe data reported here begins to clarify the functional domains of the P. knowlesi RBLs. A binding domain has been identified and characterized in PkNBPXb. Notably, this study demonstrates that unlike PkNBPXb, PkNBPXa can bind to human erythrocytes, suggesting that PkNBPXa may function as a ligand to enable the invasion of P. knowlesi merozoites into human cells.

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Open Access | Invited Speaker Presentation: Insights from monkey malaria that can change thinking about human infections

November 3, 2010 - 12:27 -- Patrick Sampao
Author(s): 
Janet Cox-Singh
Reference: 
Malaria Journal 2010, 9(Suppl 2):I2 (20 October 2010)

Despite prolonged and intense effort to understand and control the health impact of malaria morbidity and mortality, malaria remains third in the global ranking for severe and fatal infections.

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