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Not Open Access | Pathogenesis of malaria-associated acute respiratory distress syndrome

June 28, 2013 - 18:30 -- NOT Open Access
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Author(s): 
Philippe E. Van den Steen, Katrien Deroost, Julie Deckers, Evelien Van Herck, Sofie Struyf, Ghislain Opdenakker
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Trends in Parasitology, Volume 29, Issue 7, July 2013, Pages 346-358
MalariaWorld

We discuss and compare the pathogenesis of MA-ARDS in patients and in different murine models, including recent models without cerebral involvement, and summarize the roles of different leukocyte subclasses, adhesion molecules, cytokines, and chemokines.

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Not Open Access | Review: The mechanistic, diagnostic and prognostic utility of biomarkers in severe malaria

June 10, 2013 - 14:41 -- NOT Open Access
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Author(s): 
Laurens Manning & Timothy Mark Earls Davis
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Biomarkers in Medicine, June 2013, Vol. 7, No. 3, Pages 363-380
MalariaWorld

This literature review summarizes available data on how biomarkers might be applied to diagnose, prognosticate and provide mechanistic insights in patients with severe malaria. 

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Not Open Access | Toll like receptor 2 and 4 polymorphisms in malaria endemic populations of India

January 29, 2013 - 05:16 -- NOT Open Access
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Author(s): 
Prerna Bali, Sabyasachi Pradhan, Divya Sharma, Tridibes Adak
Reference: 
Human Immunology, Volume 74, Issue 2, February 2013, Pages 223-229
MalariaWorld

In this study 264 malaria patients from seven different eco epidemiological regions of India were genotyped for TLR2 and TLR4 polymorphisms using DNA sequencing methods.

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Not Open Access | Population pharmacokinetics of halofantrine in healthy volunteers and patients with symptomatic falciparum malaria

October 16, 2012 - 16:45 -- Patrick Sampao
Author(s): 
Klein K, Aarons L, Ter Kuile FO, Nosten F, White NJ, Edstein MD, Teja-Isavadharm P.
Reference: 
J Pharm Pharmacol. 2012 Nov;64(11):1603-1613

MalariaWorldTo investigate the population pharmacokinetics of the antimalarial halofantrine (HF) in healthy volunteers and patients with symptomatic falciparum malaria.

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Not Open Access | Naturally acquired antibodies to Plasmodium vivax blood-stage vaccine candidates (PvMSP-119 and PvMSP-3α359−798) and their relationship with hematological features in malaria patients from the Brazilian Amazon

July 2, 2012 - 13:26 -- Patrick Sampao
Author(s): 
Luiza Carvalho Mourão, Cristiane Guimarães Morais, Érika Martins Braga, et al.
Reference: 
Microbes and Infection, Volume 14, Issue 9, August 2012, Pages 730-739

MalariaWorldWe investigated specific antibody responses against two Plasmodium vivax vaccine candidates, PvMSP-119 and PvMSP-3α359−798. Moreover, we assessed the relationship between these antibodies and morbidity parameters.

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Activation of nuclear factor kappa B in peripheral blood mononuclear cells from malaria patients

June 13, 2012 - 15:27 -- Patrick Sampao
Author(s): 
Punsawad C, Krudsood S, Maneerat Y, Chaisri U, Tangpukdee N, Pongponratn E, Nantavisai K, Udomsangpetch R, Viriyavejakul P
Reference: 
Malaria Journal 2012, 11:191 (10 June 2012)

MalariaWorldThis is the first report demonstrating alterations in NF-kappaB p65 activity in the PBMCs of malaria patients. The altered lower features of NF-kappaB p65 in the PBMCs of patients with complicated P. falciparum at admission could be due to a suppressive effect of high IL-10 associated with complicated P. falciparum malaria.

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Open Access | Improving access to health care for malaria in Africa: a review of literature on what attracts patients

February 28, 2012 - 10:58 -- Patrick Sampao
Author(s): 
Kizito J, Kayendeke M, Nabirye C, Staedke SG, Chandler CI
Reference: 
Malaria Journal 2012, 11:55 (23 February 2012)

MalariaWorldThis paper argues that improving access to services requires attention to factors that will attract patients, and recommends that public services are improved in the specific aspects identified in this review.

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Open Access | Performance of Two Malaria Rapid Diagnostic Tests in Febrile Adult Patients with and without Human Immunodeficiency Virus-1 Infection in Blantyre, Malawi

February 2, 2012 - 11:52 -- Patrick Sampao
Author(s): 
Jobiba Chinkhumba, Monica Nyanda, Jacek Skarbinski and Don P. Mathanga
Reference: 
Am J Trop Med Hyg 2012 86:199-202

MalariaWorldThe performance of two histidine-rich protein type-2–based malaria rapid diagnostic tests (mRDTs) was examined in a rural area with a high prevalence of malaria and human immunodeficiency virus type-1 (HIV-1) infection in 113 and 445 febrile patients ≥ 15 years of age with and without HIV-1 infection, respectively.

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Prevalence of Malaria among Patients Attending Public Health Facilities in Maputo City, Mozambique.

December 8, 2011 - 15:35 -- Patrick Sampao
Author(s): 
Macedo de Oliveira A, Mutemba R, Morgan J, Streat E, Roberts J, Menon M, Mabunda S.
Reference: 
Am J Trop Med Hyg. 2011 Dec;85(6):1002-7.

MalariaWorldA malaria case was defined as a positive result for malaria by microscopy in a patient with fever or history of fever in the previous 24 hours.

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Review: improving the therapeutic index of 8-aminoquinolines by the use of drug combinations: review of the literature and proposal for future investigations.

December 8, 2011 - 15:31 -- Patrick Sampao
Author(s): 
Myint HY, Berman J, Walker L, Pybus B, Melendez V, Baird JK, Ohrt C.
Reference: 
Am J Trop Med Hyg. 2011 Dec;85(6):1010-4.

MalariaWorldReview of the mid-20th century literature in the light of present understanding of pharmacokinetics and metabolism suggests that manipulation of these factors might dissociate 8-aminoquinoline efficacy from toxicity and lead to an improved therapeutic index.

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