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Humans

Duffy Phenotype and Plasmodium vivax Infections in Humans and Apes, Africa

October 1, 2012 - 17:40 -- Patrick Sampao
Author(s): 
R.L. Culleton and P.E. Ferreira
Reference: 
Emerging Infectious Diseases, October 2012

MalariaWorldThese findings are supported by a report from Madagascar (where the human population is composed of a mixture of Duffy-positive and Duffy-negative persons), in which 42 (8.8%) of 476 Duffy-negative persons who had symptoms of malaria were reported to be positive for P. vivax by both microscopy and PCR.

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Open Access | First clinical trial of purified, irradiated malaria sporozoites in humans

December 9, 2011 - 13:04 -- Patrick Sampao
Author(s): 
Claudia A Daubenberger
Reference: 
Expert Review of Vaccines, January 2012, Vol. 11, No. 1, Pages 31-33

MalariaWorldThis PfSPZ vaccine has been shown to be safe but of low immunogenicity and hence protective efficacy as shown after challenge with infected mosquitoes.

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Parasitology: Accurate and Sensitive Detection of Plasmodium Species in Humans by Use of the Dihydrofolate Reductase-Thymidylate Synthase Linker Region

October 1, 2010 - 10:03 -- Patrick Sampao
Author(s): 
Naowarat T., Mallika I., et al.
Reference: 
J. Clin. Microbiol., Oct 2010; 48: 3735 - 3737.

A nested-PCR protocol based on the linker region of the Plasmodium dihydrofolate reductase-thymidylate synthase gene (dhfr-ts) was developed.

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