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Microbial Immunity and Vaccines: Allele Specificity of Gamma Interferon Responses to the Carboxyl-Terminal Region of Plasmodium falciparum Merozoite Surface Protein 1 by Kenyan Adults with Naturally Acquired Immunity to Malaria

September 24, 2010 - 13:25 -- Patrick Sampao
Author(s): 
Michele D., Kiprotich C., et al.
Reference: 
Infect. Immun., Oct 2010; 78: 4431 - 4441.

This study demonstrates that immunity against MSP133 after cumulative natural infections consists of low-magnitude and difficult-to-detect IFN responses.

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Erratum: New Fixed-Dose Artesunate-Mefloquine Formulation against Multidrug-Resistant Plasmodium falciparumin Adults: a Comparative Phase IIb Safety and Pharmacokinetic Study with Standard-Dose Nonfixed Artesunate plus Mefloquine

September 21, 2010 - 08:47 -- Kabogo Ndegwa
Author(s): 
S. Krudsood, S. Looareesuwan, N. Tangpukdee, P. Wilairatana, W. Phumratanaprapin, W. Leowattana, K. Chalermrut, S. Ramanathan, V. Navaratnam, P. Olliaro, M. Vaillant, J. R. Kiechel, and W. R. J. Taylor
Reference: 
Antimicrobial Agents and Chemotherapy, October 2010, p. 4526, Vol. 54, No. 10

Giemsa-stained thick and thin blood films were examined at baseline; every 6 hours for the first 3 days;

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Open Access | Immunoglobulin GM 3 23 5,13,14 phenotype is strongly associated with IgG1 antibody responses to Plasmodium vivax vaccine candidate antigens PvMSP1-19 and PvAMA-1

August 11, 2010 - 13:03 -- Kabogo Ndegwa
Author(s): 
Pandey JP, Morais CG, Fontes CJ, Braga EM
Reference: 
Malaria Journal 2010, 9:229 (9 August 2010)

Results presented here show that immunoglobulin GM allotypes contribute to the natural antibody responses to P. vivax malaria antigens. These findings have important implications for the effectiveness of vaccines containing PvAMA-1 or PvMSP1-19 antigens.

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Open Access | Community acceptability of use of rapid diagnostic tests for malaria by community health workers in Uganda

July 14, 2010 - 12:54 -- Kabogo Ndegwa
Author(s): 
Mukanga D, Tibenderana JK, Kiguli J, Pariyo GW, Waiswa P, Bajunirwe F, Mutamba B, Counihan H, Ojiambo G, Kallander K
Reference: 
Malaria Journal 2010, 9:203 (13 July 2010)

Use of RDTs by CMDs is likely to be acceptable by community members given that CMDs are properly trained, and receive regular technical supervision and logistical support. A well-designed behaviour change communication strategy is needed to address the anticipated programmatic challenges as well as community fears and stigma about drawing blood.

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Open Access | Prescribing practice for malaria following introduction of artemether-lumefantrine in an urban area with declining endemicity in West Africa

June 25, 2010 - 09:21 -- Kabogo Ndegwa
Author(s): 
Okebe JU, Walther B, Bojang K, Drammeh S, Schellenberg D, Conway DJ, Walther M
Reference: 
Malaria Journal 2010, 9:180 (24 June 2010)

The study provides evidence for considerable overtreatment for malaria in a West African setting comparable to reports from areas with similar low malaria transmission in East Africa. The data suggest that laboratory facilities may be under-used, and that adherence to negative PHF slide results could significantly reduce the degree of overtreatment.

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Open Access | High Level of Pyrethroid Resistance in an Anopheles funestus Population of the Chokwe District in Mozambique

June 11, 2010 - 09:12 -- Kabogo Ndegwa
Author(s): 
Nelson Cuamba, John C. Morgan, Helen Irving, Andrew Steven, Charles S. Wondji
Reference: 
PLoS ONE 5(6): e11010.

The high level of pyrethroid resistance in this population despite the cessation of pyrethroid use for IRS in 1999 is a serious concern for resistance management strategies such as rotational use of insecticides. As DDT has now been re-introduced for IRS, susceptibility to DDT needs to be closely monitored to prevent the appearance and spread of resistance to this insecticide.

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Abundance patterns of Anopheles pseudopunctipennis and Anopheles argyritarsis in northwestern Argentina

June 9, 2010 - 08:25 -- Kabogo Ndegwa
Author(s): 
María Julia Dantur Juri, Guillermo Luis Claps, Mirta Santana, Mario Zaidenberg, Walter Ricardo Almirón
Reference: 
Acta Tropica, Volume 115, Issue 3, September 2010, Pages 234-241

Anopheles pseudopunctipennis is an important malaria vector in Argentina but the role of Anopheles argyritarsis in the transmission of the parasite is still unknown. Abundance patterns of both species and their relationship to climatic variables were studied in the subtropical mountainous forest in northwestern Argentina.

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Open Access | The economic costs of malaria in four Kenyan districts: do household costs differ by disease endemicity?

June 3, 2010 - 08:11 -- Kabogo Ndegwa
Author(s): 
Chuma J, Okungu V, Molyneux C
Reference: 
Malaria Journal 2010, 9:149 (2 June 2010)

Cost burdens are the product of complex relationships between social, economic and epidemiological factors. The cost data presented in this study reflect transmission patterns in the four districts, suggesting that a relationship between costs burdens and the nature of transmission might exist, and that the same warrants more attention from researchers and policy makers.

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Open Access | Short Report: An update of malaria infection and anaemia in adults in Buea, Cameroon

May 10, 2010 - 09:21 -- Kabogo Ndegwa
Author(s): 
EN Takem, EA Achidi, PM Ndumbe
Reference: 
BMC Research Notes 2010, 3:121

In adult patients with fever in this setting, malaria parasitaemia contributes to anaemia and is of public health impact. Our results also provide a baseline prevalence for malaria parasitaemia in febrile adults in health units in this setting.

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Open Access | Increased Asymmetric Dimethylarginine in Severe Falciparum Malaria: Association with Impaired Nitric Oxide Bioavailability and Fatal Outcome

April 27, 2010 - 13:44 -- Kabogo Ndegwa
Author(s): 
Tsin W. Yeo, Daniel A. Lampah, Nicholas M. Anstey,. et al
Reference: 
PLoS Pathog 6(4): e1000868

Asymmetrical dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase (NOS), is a predictor of mortality in critical illness. Severe malaria (SM) is associated with decreased NO bioavailability, but the contribution of ADMA to the pathogenesis of impaired NO bioavailability and adverse outcomes in malaria is unknown.

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