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adults

Open Access | Measuring naturally acquired immune responses to candidate malaria vaccine antigens in Ghanaian adults

June 22, 2011 - 07:06 -- Kabogo Ndegwa
Author(s): 
Dodoo D, Hollingdale MR, Anum D, Koram KA, Gyan B, Akanmori BD, Ocran J, Adu-Amankwah S, Ganeshan H, Abot E, Legano J, Banania G, Sayo R, Brambilla D, Kumar S, Doolan DL, Rogers WO, Epstein J, Richie TL, Sedegah M
Reference: 
Malaria Journal 2011, 10:168 (20 June 2011)

All participants were positive for at least one malaria protein by ELISA, with results dependent on the criteria for positivity.

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Open Access | Low prevalence of Plasmodium falciparum antigenaemia among asymptomatic HAART-treated adults in an urban cohort in Uganda

March 23, 2011 - 08:48 -- Kabogo Ndegwa
Author(s): 
Nakanjako D, Kiragga AN, Castelnuovo B, Kyabayinze DJ, Kamya MR
Reference: 
Malaria Journal 2011, 10:66 (22 March 2011)

In an urban area of low to moderate stable malaria transmission, there was low HRP2 P. falciparum antigenaemia among PLHIV after long-term HAART and cotrimoxazole prophylaxis.

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Effect of artesunate and mefloquine in combination on the Fridericia corrected QT intervals in Plasmodium falciparum infected adults from Thailand

March 17, 2011 - 08:49 -- Kabogo Ndegwa
Author(s): 
S. Krudsood, S. Looareesuwan, P. Wilairatama, W. Leowattana, N. Tangpukdee, K. Chalermrut, S. Ramanathan, V. Navaratnam, P. Olliaro, M. Vaillant, J. R. Kiechel and W. R. J. Taylor
Reference: 
Tropical Medicine & International Health, Volume 16, Issue 4, pages 458–465, April 2011

In this small group of patients, slowing heart rates due to malaria resolution best explained the observed increases in the QTcF intervals.

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Open Access | Prevalence of Plasmodium falciparum infection in asymptomatic rural Gabonese populations

February 10, 2011 - 11:51 -- Kabogo Ndegwa
Author(s): 
Nkoghe D, Akue J, Gonzalez J, Leroy EM
Reference: 
Malaria Journal 2011, 10:33 (9 February 2011)

Plasmodium falciparum carriage remains high among adults in rural Gabon. Control measures must be adapted to the region and ecosystem. Routine treatment of asymptomatic individuals should be considered.

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Schistosoma mansoni: Schistosomicidal effect of mefloquine and primaquine in vitro

January 3, 2011 - 09:14 -- Kabogo Ndegwa
Author(s): 
M.C. Holtfreter, M. Loebermann, S. Klammt, M. Sombetzki, P. Bodammer, D. Riebold, R. Kinzelbach, E.C. Reisinger
Reference: 
Experimental Parasitology, Volume 127, Issue 1, January 2011, Pages 270-276

We investigated the effects of the anti-malarials mefloquine and primaquine against the juvenile and adult life stages of Schistosoma mansoni in vitro.

Open Access | Is staying overnight in a farming hut a risk factor for malaria infection in a setting with insecticide-treated bed nets in rural Laos?

December 29, 2010 - 11:36 -- Kabogo Ndegwa
Author(s): 
Open Access | Is staying overnight in a farming hut a risk factor for malaria infection in a setting with insecticide-treated bed nets in rural Laos?
Reference: 
Malaria Journal 2010, 9:372 (23 December 2010)

This study showed that staying overnight in farming huts was not associated with an increased risk of malaria infection in the setting where ITNs were widely used in farming huts.

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Open Access | Cost comparison of microscopy vs empiric treatment for malaria in south-western Nigeria: a prospective study

December 23, 2010 - 14:02 -- Kabogo Ndegwa
Author(s): 
Parikh R, Amole I, Tarpley M, Gbadero D, Davidson M, Vermund SH
Reference: 
Malaria Journal 2010, 9:371 (22 December 2010)

Empiric treatment of all suspected cases of malaria was cheaper (in the end of dry to beginning of rainy season) than only treating those who had microscopy confirmed diagnoses of malaria even though the majority of patients suspected to have malaria were negative via microscopy.

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Open Access | A study of the TNF/LTA/LTB locus and susceptibility to severe malaria in highland Papuan children and adults

November 3, 2010 - 06:48 -- Kabogo Ndegwa
Author(s): 
Randall LM, Kenangalem E, Engwerda CR, et al.
Reference: 
Malaria Journal 2010, 9:302 (29 October 2010)

These results support the notion that unique selective pressure on the TNF/LTA/LTB locus in different populations has influenced the contribution of the gene products from this region to SM susceptibility.

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Open Access | Severe Imported Falciparum Malaria: A Cohort Study in 400 Critically Ill Adults

October 18, 2010 - 08:52 -- Patrick Sampao
Author(s): 
Fabrice B., Florence T., et al.
Reference: 
PLoS ONE 5(10): e13236.

Data from 400 adults admitted to the intensive care unit were analysed, representing the largest series of severe imported malaria to date. Median age was 45 years; 60% of patients were white, 96% acquired the disease in sub-Saharan Africa, and 65% had not taken antimalarial chemoprophylaxis.

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Open Access | The plasticity of Plasmodium falciparum gametocytaemia in relation to age in Burkina Faso

October 16, 2010 - 08:23 -- Kabogo Ndegwa
Author(s): 
Ouedraogo A, Bousema T, de Vlas SJ, Cuzin-Ouattara N, Verhave J, Drakeley C, Luty AJ, Sauerwein R
Reference: 
Malaria Journal 2010, 9:281 (12 October 2010)

The findings of this study suggest that although gametocytes are most commonly detected in children, the proportion of asexual parasites that is committed to develop into gametocytes may increase with age. These findings underscore the importance of adults for the human infectious reservoir for malaria.

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