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Plasmodium vivax cerebral malaria in an adult patient in Sudan

September 23, 2019 - 14:18 -- Open Access
Author(s): 
Maowia M. Mukhtar, Omer A. Eisawi, Seth A. Amanfo, Elwaleed M. Elamin, Zeinab S. Imam, Faiza M. Osman and Manasik E. Hamed
Reference: 
Malaria Journal 2019 18:316, 18 September 2019

Plasmodium vivax infection is rising in sub-Saharan Africa, where Plasmodium falciparum is responsible for more than 90% of malaria cases. While P. vivax is identified as a major cause of severe and cerebral malaria in South east Asia, the Pacific and South America, most of the severe and cerebral cases in Africa were attributed to P. falciparum. Cases of severe malaria due to P. vivax are emerging in Africa. A few severe P. vivax cases were reported in Eastern Sudan and they were underestimated due to the lack of accurate diagnosis, low parasitaemia and seldom use of rapid diagnostic tests (RDTs).

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Phase 1 randomized controlled trial to evaluate the safety and immunogenicity of recombinant Pichia pastoris-expressed Plasmodium falciparum apical membrane antigen 1 (PfAMA1-FVO [25-545]) in healthy Malian adults in Bandiagara

September 3, 2016 - 16:34 -- Open Access
Author(s): 
Mahamadou A. Thera, Drissa Coulibaly, Ogobara K. Doumbo, et al.
Reference: 
Malaria Journal 2016 15:442, 30 August 2016

The PfAMA1 showed a good safety profile. Most adverse events reported were of mild to moderate intensity.

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NOT Open Access | Designing a Pediatric Study for an Antimalarial Drug by Using Information from Adults

March 5, 2016 - 23:52 -- NOT Open Access
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Author(s): 
Caroline Petit, Vincent Jullien, Adeline Samson, Jérémie Guedj, Jean-René Kiechel, Sarah Zohar, and Emmanuelle Comets
Reference: 
Antimicrob. Agents Chemother. March 2016 vol. 60 no. 3 1481-1491

The objectives of this study were to design a pharmacokinetic (PK) study by using information about adults and evaluate the robustness of the recommended design through a case study of mefloquine.

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Measurement of ex vivo ELISpot interferon-gamma recall responses to Plasmodium falciparum AMA1 and CSP in Ghanaian adults with natural exposure to malaria

February 8, 2016 - 17:05 -- Open Access
Author(s): 
Harini Ganeshan, Kwadwo A. Kusi, Martha Sedegah, et al.
Reference: 
Malaria Journal 2016 15:55, 1 February 2016

These results generally demonstrate that CSP and AMA1 peptides recalled ELISpot IFN-γ responses from naturally exposed individuals and that both CSP and AMA1 contain diverse class 1-restricted epitopes that are HLA-promiscuous and are widely recognized in this population.

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Pharmacokinetic interactions between artesunate-mefloquine and ritonavir-boosted lopinavir in healthy Thai adults

October 14, 2015 - 06:50 -- Open Access
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Author(s): 
Siwalee Rattanapunya, Tim Cressey, Ronnatrai Rueangweerayut, Yardpiroon Tawon, Panida Kongjam, Kesara Na-Bangchang
Reference: 
Malaria Journal 2015, 14:400 (9 October 2015)

The reduction in systemic exposure of all investigated drugs raises concerns of an increased risk of treatment failure rate in co-infected patients and should be further investigated.

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HIV Malaria Co-Infection Is Associated with Atypical Memory B Cell Expansion and a Reduced Antibody Response to a Broad Array of Plasmodium falciparum Antigens in Rwandan Adults

May 12, 2015 - 11:38 -- Open Access
Author(s): 
Krishanthi S. Subramaniam, Jeff Skinner, Emil Ivan, Eugene Mutimura, Ryung S. Kim, Catherine M. Feintuch, Silvia Portugal, Kathryn Anastos, Peter D. Crompton, Johanna P. Daily
Reference: 
PLoS ONE 10(4): e0124412

HIV infected individuals in malaria endemic areas experience more frequent and severe malaria episodes compared to non HIV infected.

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Measuring naturally acquired ex vivo IFN-γ responses to Plasmodium falciparum cell-traversal protein for ookinetes and sporozoites (CelTOS) in Ghanaian adults

February 3, 2015 - 16:10 -- Open Access
Author(s): 
Dorothy Anum, Kwadwo A Kusi, Martha Sedegah, et al.
Reference: 
Malaria Journal 2015, 14:20 (21 January 2015)

These results suggest natural malaria transmission induces CelTOS-specific ex vivo IFN-γ in Ghanaian adults and that the frequency of these responses was similar to those of other previously characterized malaria antigens.

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Efficacy and safety of a combination of azithromycin and chloroquine for the treatment of uncomplicated Plasmodium falciparum malaria in two multicountry randomized clinical trials in African adults

December 10, 2014 - 16:20 -- Open Access
Author(s): 
Issaka Sagara, Abraham R Oduro, Michael W Dunne, et al.
Reference: 
Malaria Journal 2014, 13:458 (25 November 2014)

Among adults with symptomatic uncomplicated falciparum malaria in Africa, the combination of AZ 1,000 mg and CQ 600-mg base once daily for three days resulted in Day-28 PCR-corrected parasitological clearance rates of >=98% and was non-inferior to treatment with MQ. AZCQ was well tolerated.

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NOT Open Access | HIV-Positive Nigerian Adults Harbor Significantly Higher Serum Lumefantrine Levels than HIV-Negative Individuals Seven Days after Treatment for Plasmodium falciparum Infection

August 22, 2013 - 08:47 -- NOT Open Access
Author(s): 
Ifeyinwa Chijioke-Nwauche, Albert van Wyk, Chijioke Nwauche, Khalid B. Beshir, Harparkash Kaur, and Colin J. Sutherland
Reference: 
Antimicrob. Agents Chemother. September 2013 vol. 57 no. 9 4146-4150
MalariaWorld

Management of coinfection with malaria and HIV is a major challenge to public health in developing countries, and yet potential drug-drug interactions between antimalarial and antiviral regimens have not been adequately investigated in people with both infections.

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Plasmodium falciparum responds to amino acid starvation by entering into a hibernatory state

November 21, 2012 - 07:01 -- Open Access
Author(s): 
Shalon E. Babbitt, Lindsey Altenhofen, Simon A. Cobbold, Eva S. Istvan, Clare Fennell, Christian Doerig, Manuel Llinás, and Daniel E. Goldberg
Reference: 
PNAS November 20, 2012 vol. 109 no. 47 E3278-E3287
MalariaWorld

The human malaria parasite Plasmodium falciparum is auxotrophic for most amino acids.

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