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adults

Phase 1 randomized controlled trial to evaluate the safety and immunogenicity of recombinant Pichia pastoris-expressed Plasmodium falciparum apical membrane antigen 1 (PfAMA1-FVO [25-545]) in healthy Malian adults in Bandiagara

September 3, 2016 - 16:34 -- Open Access
Author(s): 
Mahamadou A. Thera, Drissa Coulibaly, Ogobara K. Doumbo, et al.
Reference: 
Malaria Journal 2016 15:442, 30 August 2016

The PfAMA1 showed a good safety profile. Most adverse events reported were of mild to moderate intensity.

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NOT Open Access | Designing a Pediatric Study for an Antimalarial Drug by Using Information from Adults

March 5, 2016 - 23:52 -- NOT Open Access
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Author(s): 
Caroline Petit, Vincent Jullien, Adeline Samson, Jérémie Guedj, Jean-René Kiechel, Sarah Zohar, and Emmanuelle Comets
Reference: 
Antimicrob. Agents Chemother. March 2016 vol. 60 no. 3 1481-1491

The objectives of this study were to design a pharmacokinetic (PK) study by using information about adults and evaluate the robustness of the recommended design through a case study of mefloquine.

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Measurement of ex vivo ELISpot interferon-gamma recall responses to Plasmodium falciparum AMA1 and CSP in Ghanaian adults with natural exposure to malaria

February 8, 2016 - 17:05 -- Open Access
Author(s): 
Harini Ganeshan, Kwadwo A. Kusi, Martha Sedegah, et al.
Reference: 
Malaria Journal 2016 15:55, 1 February 2016

These results generally demonstrate that CSP and AMA1 peptides recalled ELISpot IFN-γ responses from naturally exposed individuals and that both CSP and AMA1 contain diverse class 1-restricted epitopes that are HLA-promiscuous and are widely recognized in this population.

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Pharmacokinetic interactions between artesunate-mefloquine and ritonavir-boosted lopinavir in healthy Thai adults

October 14, 2015 - 06:50 -- Open Access
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Author(s): 
Siwalee Rattanapunya, Tim Cressey, Ronnatrai Rueangweerayut, Yardpiroon Tawon, Panida Kongjam, Kesara Na-Bangchang
Reference: 
Malaria Journal 2015, 14:400 (9 October 2015)

The reduction in systemic exposure of all investigated drugs raises concerns of an increased risk of treatment failure rate in co-infected patients and should be further investigated.

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HIV Malaria Co-Infection Is Associated with Atypical Memory B Cell Expansion and a Reduced Antibody Response to a Broad Array of Plasmodium falciparum Antigens in Rwandan Adults

May 12, 2015 - 11:38 -- Open Access
Author(s): 
Krishanthi S. Subramaniam, Jeff Skinner, Emil Ivan, Eugene Mutimura, Ryung S. Kim, Catherine M. Feintuch, Silvia Portugal, Kathryn Anastos, Peter D. Crompton, Johanna P. Daily
Reference: 
PLoS ONE 10(4): e0124412

HIV infected individuals in malaria endemic areas experience more frequent and severe malaria episodes compared to non HIV infected.

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Measuring naturally acquired ex vivo IFN-γ responses to Plasmodium falciparum cell-traversal protein for ookinetes and sporozoites (CelTOS) in Ghanaian adults

February 3, 2015 - 16:10 -- Open Access
Author(s): 
Dorothy Anum, Kwadwo A Kusi, Martha Sedegah, et al.
Reference: 
Malaria Journal 2015, 14:20 (21 January 2015)

These results suggest natural malaria transmission induces CelTOS-specific ex vivo IFN-γ in Ghanaian adults and that the frequency of these responses was similar to those of other previously characterized malaria antigens.

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Efficacy and safety of a combination of azithromycin and chloroquine for the treatment of uncomplicated Plasmodium falciparum malaria in two multicountry randomized clinical trials in African adults

December 10, 2014 - 16:20 -- Open Access
Author(s): 
Issaka Sagara, Abraham R Oduro, Michael W Dunne, et al.
Reference: 
Malaria Journal 2014, 13:458 (25 November 2014)

Among adults with symptomatic uncomplicated falciparum malaria in Africa, the combination of AZ 1,000 mg and CQ 600-mg base once daily for three days resulted in Day-28 PCR-corrected parasitological clearance rates of >=98% and was non-inferior to treatment with MQ. AZCQ was well tolerated.

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NOT Open Access | HIV-Positive Nigerian Adults Harbor Significantly Higher Serum Lumefantrine Levels than HIV-Negative Individuals Seven Days after Treatment for Plasmodium falciparum Infection

August 22, 2013 - 08:47 -- NOT Open Access
Author(s): 
Ifeyinwa Chijioke-Nwauche, Albert van Wyk, Chijioke Nwauche, Khalid B. Beshir, Harparkash Kaur, and Colin J. Sutherland
Reference: 
Antimicrob. Agents Chemother. September 2013 vol. 57 no. 9 4146-4150
MalariaWorld

Management of coinfection with malaria and HIV is a major challenge to public health in developing countries, and yet potential drug-drug interactions between antimalarial and antiviral regimens have not been adequately investigated in people with both infections.

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Plasmodium falciparum responds to amino acid starvation by entering into a hibernatory state

November 21, 2012 - 07:01 -- Open Access
Author(s): 
Shalon E. Babbitt, Lindsey Altenhofen, Simon A. Cobbold, Eva S. Istvan, Clare Fennell, Christian Doerig, Manuel Llinás, and Daniel E. Goldberg
Reference: 
PNAS November 20, 2012 vol. 109 no. 47 E3278-E3287
MalariaWorld

The human malaria parasite Plasmodium falciparum is auxotrophic for most amino acids.

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Not Open Access | Significant pharmacokinetic interactions between artemether/lumefantrine and efavirenz or nevirapine in HIV-infected Ugandan adults

August 15, 2012 - 09:51 -- Patrick Sampao
Author(s): 
Pauline Byakika-Kibwika, Mohammed Lamorde, Concepta Merry, et al.
Reference: 
J. Antimicrob. Chemother. (2012) 67 (9): 2213-2221

MalariaWorldWe investigated drug–drug interactions between artemether/lumefantrine and efavirenz or nevirapine.

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