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infants

Risks of Hemolysis in Glucose-6-Phosphate Dehydrogenase Deficient Infants Exposed to Chlorproguanil-Dapsone, Mefloquine and Sulfadoxine-Pyrimethamine as Part of Intermittent Presumptive Treatment of Malaria in Infants

December 15, 2015 - 14:29 -- Open Access
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Author(s): 
Eugenie Poirot, Eric Vittinghoff, Roland Gosling, et al.
Reference: 
PLoS ONE 10(11): e0142414

While treatment with CD demonstrated greater reductions in Hb at 7 and 14 days after an IPTi dose compared to both SP and MQ, there was no evidence that G6PD deficiency exacerbated the adverse effects of CD, despite evidence for higher hemolysis risk among G6PDd infants.

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Increased systemic exposures of artemether and dihydroartemisinin in infants under 5 kg with uncomplicated Plasmodium falciparum malaria treated with artemether-lumefantrine (Coartem®)

April 20, 2015 - 17:26 -- Open Access
Author(s): 
Alfred B Tiono, Halidou Tinto, Kamal Hamed, et al.
Reference: 
Malaria Journal 2015, 14:157 (15 April 2015)

A three-day regimen of AL dispersible formulation was efficacious and generally well tolerated in infants weighing <5 kg with uncomplicated P. falciparum malaria, but artemether and dihydroartemisinin exposures could not be supported by the preclinical safety margins for neurotoxicity.

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The effect of immunization schedule with the malaria vaccine candidate RTS,S/AS01E on protective efficacy and anti-circumsporozoite protein antibody avidity in African infants

March 10, 2015 - 13:31 -- Open Access
Author(s): 
Anthony Ajua, Bertrand Lell, Benjamin Mordmüller, et al.
Reference: 
Malaria Journal 2015, 14:72 (13 February 2015)

So far, only the quantity of anti-CSP IgG has been measured and used to predict vaccination success, although quality (measured as avidity) of the antigen-antibody interaction shall be important since only a few sporozoites circulate for a short time after an infectious mosquito bite, likely requiring fast and strong binding.

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Mass distribution of free insecticide-treated nets do not interfere with continuous net distribution in Tanzania

June 10, 2014 - 12:34 -- Open Access
Author(s): 
Eze IC, Kramer K, Msengwa A, Mandike R, Lengeler C
Reference: 
Malaria Journal 2014, 13 :196 (27 May 2014)

The key components of the National Treated Nets Programme (NATNETS) seem to work harmoniously, leading to a high level of net use in the entire population.

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Cytokine Profiles at Birth Predict Malaria Severity during Infancy

October 22, 2013 - 07:37 -- Open Access
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Author(s): 
Edward Kabyemela, Bronner P. Gonçalves, D. Rebecca Prevots, Robert Morrison, Whitney Harrington, Moses Gwamaka, Jonathan D. Kurtis, Michal Fried, Patrick E. Duffy
Reference: 
PLoS ONE 8(10): e77214
MalariaWorld

IL-1β levels at birth are related to future IL-1β levels as well as the risk of severe malaria in early life.

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Selection of Antimalarial Drug Resistance after Intermittent Preventive Treatment of Infants and Children (IPTi/c) in Senegal

June 6, 2013 - 15:53 -- Open Access
Author(s): 
Magatte Ndiaye, Roger Tine, Babacar Faye, Jean Louis Ndiaye, Ami Colle Lo, Khadime Sylla, Annie Abiola, Yémou Dieng, Daouda Ndiaye, Rachel Hallett, Oumar Gaye and Michael Alifrangis
Reference: 
Am J Trop Med Hyg 2013 88:1124-1129
MalariaWorld

Our study investigated the possible impact of SP-IPT given to infants and children on the prevalence of SP-resistant haplotypes in the Plasmodium falciparum genes Pfdhfr and Pfdhps, comparing sites with and without IPTi/c. P. falciparum positive samples (N = 352) collected from children < 5 years were analyzed to determine the prevalence of SP resistance-related haplotypes by nested PCR followed by sequence-specific oligonucleotide probe-enzyme-linked immunosorbent assay.

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Not Open Access | The impact of placental malaria on neurodevelopment of exposed infants: a role for the complement system?

May 15, 2013 - 16:24 -- NOT Open Access
Author(s): 
Chloe R. McDonald, Robyn E. Elphinstone, Kevin C. Kain
Reference: 
Trends in Parasitology, Volume 29, Issue 5, May 2013, Pages 213-219
MalariaWorld

Based on recent evidence supporting a role for the complement system in regulating neurodevelopment, and mediating neuroinflammation and neurodegenerative diseases, we hypothesize that excessive complement activation induced by placental malaria may disrupt normal neurodevelopment resulting in neurocognitive impairment of infants exposed to malaria in utero.

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Not Open Access | Experimental Malaria Vaccine

December 19, 2012 - 12:29 -- NOT Open Access
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Author(s): 
M. J. Friedrich
Reference: 
JAMA. 2012;308(23):2449.
MalariaWorld

An experimental malaria vaccine given to African infants younger than 12 weeks reduced the risks of clinical and severe malaria only by about one-third, reports an international team of researchers (The RTS,S Clinical Trials Partnership. N Engl J Med. doi: 10.1056/NEJMoa1208394 [published online November 9, 2012]).

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Open Access | Intermittent Preventive Treatment for Malaria in Papua New Guinean Infants Exposed to Plasmodium falciparum and P. vivax: A Randomized Controlled Trial

March 30, 2012 - 12:34 -- Patrick Sampao
Author(s): 
Nicolas Senn, Patricia Rarau, Ivo Mueller, et al.
Reference: 
PLoS Med 9(3): e1001195.

MalariaWorldIn this study, 1,121 Papua New Guinean infants were enrolled into a three-arm placebo-controlled randomized trial and assigned to sulfadoxine-pyrimethamine (SP) (25 mg/kg and 1.25 mg/kg) plus amodiaquine (AQ) (10 mg/kg, 3 d, n = 374), SP plus artesunate (AS) (4 mg/kg, 3 d, n = 374), or placebo (n = 373), given at 3, 6, 9 and 12 mo. Both participants and study teams were blinded to treatment allocation.

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Open Access | Maternal malaria status and metabolic profiles in pregnancy and in cord blood: relationships with birth size in Nigerian infants

March 26, 2012 - 08:19 -- Patrick Sampao
Author(s): 
Ayoola OO, Whatmore A, Balogun WO, Jarrett OO, Cruickshank JK, Clayton PE
Reference: 
Malaria Journal 2012, 11:75 (19 March 2012)

MalariaWorldThe study objective was to define relationships between maternal and cord serum metabolic markers, maternal malaria status and birth size.

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