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World Health Organization

Indoor residual spraying for preventing malaria in communities using insecticide‐treated nets

June 17, 2019 - 15:38 -- Open Access
Author(s): 
Leslie Choi, Joseph Pryce, Paul Garner
Reference: 
Cochrane Database of Systematic Reviews 2019, Issue 5. Art. No.: CD012688

Two review authors independently assessed trials for eligibility, analyzed risk of bias, and extracted data. We used risk ratio (RR) and 95% confidence intervals (CI). We stratified by type of insecticide: ‘non‐pyrethroid‐like', as this could improve malaria control better than adding IRS insecticides that have the same way of working as the insecticide on ITNs (‘pyrethroid‐like'). We used subgroup analysis of ITN usage in the trials to explore heterogeneity. We assessed the certainty of evidence using the GRADE approach.

Medical Condition: 

Algeria and Argentina certified malaria-free by WHO

May 22, 2019 - 17:03 -- Malaria World

World Health Organization, Geneva, 22 May 2019
Algeria and Argentina have been officially recognized by WHO as malaria-free. The certification is granted when a country proves that it has interrupted indigenous transmission of the disease for at least 3 consecutive years.

Comparison of malaria treatment outcome of generic and innovator’s anti-malarial drugs containing artemether–lumefantrine combination in the management of uncomplicated malaria amongst Tanzanian children

April 14, 2019 - 17:09 -- Open Access
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Author(s): 
Manase Kilonzi, Omary Minzi, Ritah Mutagonda, Philip Sasi, Appolinary Kamuhabwa and Eleni Aklillu
Reference: 
Malaria Journal 2019 18:133, 11 April 2019

 

The findings of this study indicate that both Artefan® and Coartem® are equivalent and effective in the management of uncomplicated malaria amongst children in the Coast part of Tanzania.

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Comparison of msp genotyping and a 24 SNP molecular assay for differentiating Plasmodium falciparum recrudescence from reinfection

March 20, 2019 - 15:46 -- Open Access
Author(s): 
Joseph Fulakeza, Sarah McNitt, Karl Seydel, et al.
Reference: 
Malaria Journal 2019 18:84, 18 March 2019

The use of SNP analysis has similar sensitivity to the standard msp genotyping in determining recrudescence from reinfection.

ResistanceSim: development and acceptability study of a serious game to improve understanding of insecticide resistance management in vector control programmes

November 17, 2018 - 07:55 -- Open Access
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Author(s): 
Edward K. Thomsen, Charlotte Hemingway, Andy South, Kirsten A. Duda, Claire Dormann, Robert Farmer, Michael Coleman and Marlize Coleman
Reference: 
Malaria Journal 2018 17:422

Although the World Health Organization disseminated best practice guidelines for insecticide resistance management (IRM), Rollback Malaria’s Vector Control Working Group identified the lack of practical knowledge of IRM as the primary gap in the translation of evidence into policy. ResistanceSim is a capacity strengthening tool designed to address this gap. 

Cerebrospinal fluid Plasmodium falciparum histidine-rich protein-2 in pediatric cerebral malaria

March 27, 2018 - 15:47 -- Open Access
Author(s): 
Kiran T. Thakur, Jimmy Vareta, Karl B. Seydel, et al.
Reference: 
Malaria Journal 2018 17:125, 23 March 2018

Elevation of CSF, but not plasma PfHRP-2, is associated with death in this paediatric CM cohort. PfHRP-2 egress into the CSF may represent alteration of blood brain barrier permeability related to the sequestration of parasitized erythrocytes in the cerebral microvasculature.

Local Malaria Elimination: A Historical Perspective from Palestine 100 Years Ago Informs the Current Way Forward in Sub-Saharan Africa

March 20, 2018 - 14:26 -- Open Access
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Author(s): 
Anton Alexander, Florence V Dunkel
Reference: 
American Entomologist, Volume 63, Issue 4, 12 December 2017, Pages E1–E14

According to World Health Organization statistics, malaria kills more people in 10 days than Ebola has in recorded history.

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Singapore’s Anopheles sinensis Form A is susceptible to Plasmodium vivax isolates from the western Thailand–Myanmar border

November 20, 2017 - 15:31 -- Open Access
Author(s): 
Sook-Cheng Pang, Chiara Andolina, Francois Nosten, et al.
Reference: 
Malaria Journal 2017 16:465, 16 November 2017

Infection experiments showed that An. sinensis Form A from Singapore was susceptible to Thai–Myanmar P. vivax strain, suggesting a potential role as a malaria vector in Singapore.

Immunity as a predictor of anti-malarial treatment failure: a systematic review

April 26, 2017 - 15:31 -- Open Access
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Author(s): 
Katherine O’Flaherty, Julia Maguire, Julie A. Simpson and Freya J. I. Fowkes
Reference: 
Malaria Journal 2017 16:158, 20 April 2017

Naturally acquired malarial immunity is associated with reduced anti-malarial treatment failure in malaria endemic populations.

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Development of a pharmacovigilance safety monitoring tool for the rollout of single low-dose primaquine and artemether-lumefantrine to treat Plasmodium falciparum infections in Swaziland: a pilot study

July 27, 2016 - 07:17 -- Open Access
Author(s): 
Eugenie Poirot, Adam Soble, Roland Gosling, et al.
Reference: 
Malaria Journal 2016 15:384, 22 July 2016

Improved pharmacovigilance to monitor and promote the safety of the WHO recommendation is needed.

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