Malaria rapid diagnostic tests based on histidine-rich protein-2 have played a vital role in improving malaria case management and surveillance particularly in Africa, where Plasmodium falciparum is predominant. However, their usefulness has been threatened by the emergence of gene deletion on P. falciparum histidine rich protein 2 (pfhrp2) and P. falciparum histidine rich protein 3 (pfhrp3).
World Health Organization
Two review authors independently assessed trials for eligibility, analyzed risk of bias, and extracted data. We used risk ratio (RR) and 95% confidence intervals (CI). We stratified by type of insecticide: ‘non‐pyrethroid‐like', as this could improve malaria control better than adding IRS insecticides that have the same way of working as the insecticide on ITNs (‘pyrethroid‐like'). We used subgroup analysis of ITN usage in the trials to explore heterogeneity. We assessed the certainty of evidence using the GRADE approach.
World Health Organization, Geneva, 22 May 2019
Algeria and Argentina have been officially recognized by WHO as malaria-free. The certification is granted when a country proves that it has interrupted indigenous transmission of the disease for at least 3 consecutive years.
The findings of this study indicate that both Artefan® and Coartem® are equivalent and effective in the management of uncomplicated malaria amongst children in the Coast part of Tanzania.
The use of SNP analysis has similar sensitivity to the standard msp genotyping in determining recrudescence from reinfection.
Although the World Health Organization disseminated best practice guidelines for insecticide resistance management (IRM), Rollback Malaria’s Vector Control Working Group identified the lack of practical knowledge of IRM as the primary gap in the translation of evidence into policy. ResistanceSim is a capacity strengthening tool designed to address this gap.
Elevation of CSF, but not plasma PfHRP-2, is associated with death in this paediatric CM cohort. PfHRP-2 egress into the CSF may represent alteration of blood brain barrier permeability related to the sequestration of parasitized erythrocytes in the cerebral microvasculature.
According to World Health Organization statistics, malaria kills more people in 10 days than Ebola has in recorded history.
Infection experiments showed that An. sinensis Form A from Singapore was susceptible to Thai–Myanmar P. vivax strain, suggesting a potential role as a malaria vector in Singapore.
Naturally acquired malarial immunity is associated with reduced anti-malarial treatment failure in malaria endemic populations.