One marker, Vgsc-1014S, was associated with insecticide resistance and P. falciparum infection in wild-caught mixed aged populations of A. gambiae s.s. thereby showing how resistance may directly impact transmission.
Whilst causality of relationships requires further investigation, variation in vector species and insecticide resistance in The Gambia is associated with malaria endemicity; with a notably higher prevalence of infection and insecticide resistance in the east of the country.
An unusually high frequency of animal and mixed human-animal blood meals in the major malaria vector An. gambiae s.s. was revealed in the western Kenya highlands where bed net coverage is above the WHO target.
A simplified three-dose i.m. regimen for severe malaria in African children is non-inferior to the more complex WHO-recommended regimen.
Overall, 94.2 % (21/22) of RDTs tested had accuracy within the range recommended by the WHO, while one performed poorly, below acceptable levels.
The SPH training programme was able to improve the quality of paediatric malaria care significantly, and to maintain that improvement over time.
National malaria treatment policies are devised to guide health professionals and to facilitate diagnosis and case management.
New insecticides with different modes of action to those currently used in mosquito vector control are urgently needed.
Eighteen months after WHO updated its case management guidelines, RDT availability remained poor in the private sector in sub-Saharan Africa.
We comprehensively assessed experiences and findings on IVM in Kenya with a view to sharing lessons that might promote its wider application.