International WHO recommendations facilitated a smooth policy change driven by motivated local leadership with technical and financial support from development partners.
This study showed that the new-generation LLINs treated with pyrethroids and PBO showed better efficacy compared to conventional LLINs.
The WHO Malaria Report for 2016 mentions an alarming increase in the number of people no longer receiving protection from indoor spraying, and thus an increase in the number of people in endemic areas who have lost their immunity, due to previous intense spraying. For Africa, 10.5% of the populations were covered in 2010, but this had dropped to 5.7% by end of 2016.
In this review we aimed to assess the results of non-clinical and clinical studies with artemisinin derivatives, their mechanisms of embryotoxicity and discuss the safety of their use during pregnancy.
Artemisinin resistance phenotype as has been shown in this work, is a decrease in parasites susceptibility to artemisinin derivatives together with the parasite’s ability to recover from drug-induced dormancy after exposure to drug dosage above the in vivo clinical concentrations.
WHO recently released a report on the fight against malaria, by Cibulskis et al *. It seems very positive, in fact they claim that the progress is "remarkable". but I find two ironic aspects which are troubling.
The findings support that the WHO recommendation of adding a single low-dose of PQ to standard AL regimen is safe for the treatment of acute uncomplicated P. falciparum malaria regardless of G6PD status in Tanzania.
On World Malaria Day 2016, The Kingdom of Cambodia’s National celebrations served as a prime of example of how political will is currently being exercised in Cambodia through high-level governmental support for malaria elimination.
One marker, Vgsc-1014S, was associated with insecticide resistance and P. falciparum infection in wild-caught mixed aged populations of A. gambiae s.s. thereby showing how resistance may directly impact transmission.
Whilst causality of relationships requires further investigation, variation in vector species and insecticide resistance in The Gambia is associated with malaria endemicity; with a notably higher prevalence of infection and insecticide resistance in the east of the country.