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Global survey of malaria rapid diagnostic test (RDT) sales, procurement and lot verification practices: assessing the use of the WHO–FIND Malaria RDT Evaluation Programme (2011–2014)

May 16, 2017 - 15:01 -- Open Access
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Author(s): 
Sandra Incardona, Elisa Serra-Casas, Nora Champouillon, Christian Nsanzabana, Jane Cunningham and Iveth J. González
Reference: 
Malaria Journal 2017 16:196, 15 May 2017

This survey provided in-depth information on RDT sales and procurement dynamics, including the largely unstudied private sector, and demonstrated how the WHO–FIND Programme has positively influenced procurement practices in the public sector.

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Changing the policy for intermittent preventive treatment with sulfadoxine–pyrimethamine during pregnancy in Malawi

February 22, 2017 - 14:18 -- Open Access
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Author(s): 
Chikondi A. Mwendera, Christiaan de Jager, Herbert Longwe, Kamija Phiri, Charles Hongoro and Clifford M. Mutero
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Malaria Journal 2017 16:84, 20 February 2017

International WHO recommendations facilitated a smooth policy change driven by motivated local leadership with technical and financial support from development partners.

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WHO cone bio-assays of classical and new-generation long-lasting insecticidal nets call for innovative insecticides targeting the knock-down resistance mechanism in Benin

February 15, 2017 - 17:31 -- Open Access
Author(s): 
Marius Allossogbe, Virgile Gnanguenon, Martin Akogbeto, et al.
Reference: 
Malaria Journal 2017 16:77, 15 February 2017

This study showed that the new-generation LLINs treated with pyrethroids and PBO showed better efficacy compared to conventional LLINs.

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More people caught in the Immunity Trap in 2016

December 20, 2016 - 21:15 -- William Jobin

The WHO Malaria Report for 2016 mentions an alarming increase in the number of people no longer receiving protection from indoor spraying, and thus an increase in the number of people in endemic areas who have lost their immunity, due to previous intense spraying. For Africa, 10.5% of the populations were covered in 2010, but this had dropped to 5.7% by end of 2016.

Not Open Access : Clinical and non-clinical safety of artemisinin derivatives in pregnancy.

August 29, 2016 - 15:15 -- NOT Open Access
Author(s): 
Gomes C, Boareto AC, Dalsenter PR
Reference: 
Reprod Toxicol. 2016 Aug 6;65:194-203.

In this review we aimed to assess the results of non-clinical and clinical studies with artemisinin derivatives, their mechanisms of embryotoxicity and discuss the safety of their use during pregnancy.

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In vitro selection of Plasmodium falciparum Pfcrt and Pfmdr1 variants by artemisinin

July 27, 2016 - 07:19 -- Open Access
Author(s): 
Muturi J. Njokah, Joseph N. Kang’ethe, Johnson Kinyua, Daniel Kariuki and Francis T. Kimani
Reference: 
Malaria Journal 2016 15:381, 22 July 2016

Artemisinin resistance phenotype as has been shown in this work, is a decrease in parasites susceptibility to artemisinin derivatives together with the parasite’s ability to recover from drug-induced dormancy after exposure to drug dosage above the in vivo clinical concentrations.

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Safety of a single low-dose of primaquine in addition to standard artemether-lumefantrine regimen for treatment of acute uncomplicated Plasmodium falciparum malaria in Tanzania

June 13, 2016 - 16:23 -- Open Access
Author(s): 
Richard Mwaiswelo, Billy E. Ngasala, Irina Jovel, Roland Gosling, Zul Premji, Eugenie Poirot, Bruno P. Mmbando, Anders Björkman and Andreas Mårtensson
Reference: 
Malaria Journal 2016 15:316, 10 June 2016

The findings support that the WHO recommendation of adding a single low-dose of PQ to standard AL regimen is safe for the treatment of acute uncomplicated P. falciparum malaria regardless of G6PD status in Tanzania.

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World Malaria Day 2016 in the Kingdom of Cambodia: high-level governmental support embodies the WHO call for “political will to end malaria”

June 2, 2016 - 16:34 -- Open Access
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Author(s): 
Sara E. Canavati, Cesia E. Quintero, Huy Rekol, et al.
Reference: 
Malaria Journal 2016 15:303, 2 June 2016

On World Malaria Day 2016, The Kingdom of Cambodia’s National celebrations served as a prime of example of how political will is currently being exercised in Cambodia through high-level governmental support for malaria elimination.

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A significant association between deltamethrin resistance, Plasmodium falciparum infection and the Vgsc-1014S resistance mutation in Anopheles gambiae highlights the epidemiological importance of resistance markers

May 25, 2016 - 17:43 -- Open Access
Author(s): 
Bilali Kabula, Patrick Tungu, Emily J. Rippon, Keith Steen, William Kisinza, Stephen Magesa, Franklin Mosha and Martin James Donnelly
Reference: 
Malaria Journal 2016 15:289, 23 May 2016

One marker, Vgsc-1014S, was associated with insecticide resistance and P. falciparum infection in wild-caught mixed aged populations of A. gambiae s.s. thereby showing how resistance may directly impact transmission.

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