Routine surveillance on the therapeutic efficacy of artemisinin-based combination therapy (ACT) has been ongoing in Ghana since 2005. The sixth round of surveillance was conducted between 2015 and 2017 to determine the therapeutic efficacy of artesunate–amodiaquine (AS–AQ) and artemether–lumefantrine (AL) in 10 sentinel sites across the country.
The LAMBA has higher validity than the sWHO and may therefore be preferable in resource‐limited settings without access to routine WBC‐evaluation.
It is important to consider comorbid conditions and immunosuppression when a patient with a benign form of malaria presents with severe manifestations.
This study demonstrates that IPTp-SP treatment contributes to modify the parasite populations’ structure during pregnancy.
With this study, the immunogenicity profile of the WHO reference reagent, including seven immunoglobulin isotypes and subclasses, and more P. falciparum antigens, also those included in the leading RTS,S malaria vaccine, was better characterized.
The combination of insecticide paint on doors and windows with LLINs yielded high mortality rates in the short term against wild pyrethroid-resistant malaria vector populations.
The use of chlorfenapyr and alpha-cypermethrin together as a mixture on nets (Interceptor® G2 LN) or a combined chlorfenapyr IRS and pyrethroid LN intervention provides improved control of pyrethroid-resistant malaria vectors by inducing significantly higher levels of mortality through the chlorfenapyr component and providing personal protection through the pyrethroid component.
The uptake of ≥3 doses of SP was high in the study area.
Sri Lanka was certified as malaria-free by the WHO in September 2016, however, this new finding may pose a serious challenge to the efforts of the Ministry of Health to prevent the re-introduction of malaria transmission in the country, considering the role that An. stephensi could play in urban and high vulnerability areas of Sri Lanka.
This Thematic Series in the Malaria Journal is based on the extensive background review performed by the authors and contributed to the preparations and evidence presented at the WHO technical consultation.