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The World Health Organization (WHO)

New report from WHO on malaria elimination

June 5, 2016 - 21:09 -- Bart G.J. Knols
This report, presented on World Malaria Day 2016, focuses on the third goal from the Global Technical Strategy for malaria: 2016-2030: malaria elimination. It offers a brief analysis of recent country-level progress towards elimination and spotlights countries that are poised to reach the finish line in the next  five years.
A number of countries have had remarkable success in controlling malaria, and these achievements are hard-won. But in many respects, the hardest work is yet to come. This WHO report highlights the considerable challenges countries will face in their e orts to drive down malaria cases to zero and to prevent resurgences of this deadly disease.

Why do novel vector control tools have to be perfect if the RTS,S vaccine isn't?

October 22, 2015 - 21:46 -- Bart G.J. Knols

Last month there was great news for the malaria world: A detailed analysis of the impact of insecticide-treated bednets (LLINs), ACTs, and indoor residual spraying (IRS), showed that some 6.2 million deaths and 700 million cases were averted between 2000-2015, mostly since 2005. Add up the contribution of the vector control components, and it shows that 78% of all the gains originated from just these two tools: LLINs and IRS. Is it safe to draw the conclusion from this that vector control is and shall remain the integral and critical component that will lead us to a world without malaria by 2040? I think the answer to that is 'yes, very much so'.

A community-based education programme to reduce insecticide exposure from indoor residual spraying in Limpopo, South Africa

June 14, 2019 - 18:19 -- Open Access
Brenda Eskenazi, David I. Levine, Stephen Rauch, Muvhulawa Obida, Madelein Crause, Riana Bornman and Jonathan Chevrier
Malaria Journal 2019 18:199, 14 June 2019

Indoor residual spraying (IRS), the coating of interior walls of houses with insecticides, is common in malaria-endemic areas. While important in malaria control, IRS potentially exposes residents to harmful insecticides. The World Health Organization recommends steps to minimize exposure; however, no programme has focused on educating populations.

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Population pharmacokinetics and pharmacodynamics of the artesunate–mefloquine fixed dose combination for the treatment of uncomplicated falciparum malaria in African children

April 22, 2019 - 12:28 -- Open Access
Monia Guidi, Thomas Mercier, Manel Aouri, Laurent A. Decosterd, Chantal Csajka, Bernhards Ogutu, Gwénaëlle Carn and Jean-René Kiechel
Malaria Journal 2019 18:139, 18 April 2019

The population pharmacokinetic models developed for both AS/DHA and MQ showed a large variability in drug exposure in the investigated African paediatric population.


Detection of alleles associated with resistance to chemical insecticide in the malaria vector Anopheles arabiensis in Santiago, Cabo Verde

April 8, 2019 - 16:17 -- Open Access
Derciliano Lopes da Cruz, Marcelo Henrique Santos Paiva, Duschinka Ribeiro Duarte Guedes, Joana Alves, Lara Ferrero Gómez and Constância Flávia Junqueira Ayres
Malaria Journal 2019 18:120, 5 April 2019

This is the first study to investigate the circulation of insecticide resistance alleles in An. arabiensis from Cabo Verde.

Artemisinin-based combination therapy during pregnancy: outcome of pregnancy and infant mortality: a cohort study

March 28, 2019 - 16:32 -- Open Access
Michael Nambozi, Halidou Tinto, Umberto D’Alessandro, et al.
Malaria Journal 2019 18:105, 28 March 2019

Outcome of pregnancy and infant survival were similar between treatment arms indicating that any of the four artemisinin-based combinations could be safely used during the second and third trimester of pregnancy without any adverse effect on the baby.

Comparing the un-comparable: Olyset Plus and Olyset, different malaria impact

December 5, 2018 - 15:48 -- Open Access
Ole Skovmand
Malaria Journal 2018 17:446, 30 November 2018

Data published by the World Health Organization (WHO) when evaluating Olyset+ as well of the study of Protopopoff et al. showed that much more permethrin is available on the surface of Olyset+ than on the surface of Olyset and the relatively small and rapidly dwindling dosage of PBO may have nothing to do with the superior effect of Olyset+.

An analysis of country adoption and implementation of the 2012 WHO recommendations for intermittent preventive treatment for pregnant women in sub-Saharan Africa

October 17, 2018 - 15:13 -- Open Access
Marianne Henry, Lia Florey, Susan Youll and Julie R. Gutman
Malaria Journal 2018 17:364, 16 October 2018

Overall, coverage of both IPTp2+ and IPTp3+ has improved in recent years.

Adherence to Ebola-specific malaria case management guidelines at health facilities in Guinea during the West African Ebola epidemic

June 19, 2018 - 14:39 -- Open Access
Ian Hennessee, Timothée Guilavogui, Alioune Camara, Eric S. Halsey, Barbara Marston, Deborah McFarland, Matthew Freeman and Mateusz M. Plucinski
Malaria Journal 2018 17:230, 14 June 2018

Adherence to guidance on malaria case management in EVD-affected countries was low at the height of the EVD epidemic in Guinea, and there was substantial malaria diagnostic testing in the absence of adequate PPE, which could have contributed to increased EVD transmission in the healthcare setting.


Resistance screening and trend analysis of imported falciparum malaria in NSW, Australia (2010 to 2016)

June 5, 2018 - 14:48 -- Open Access
Christiane Prosser, Wieland Meyer, John Ellis, Rogan Lee
PLoS ONE 13(5): e0197369

The C580Y finding from outside of the greater Mekong subregion supports the consensus to upscale molecular surveillance of artemisinin resistance outside of South East Asia.

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