Mutations in pfkelch13 and the six background genes may not play an important role in the in vivo selection after artemether–lumefantrine treatment in Uganda.
These findings generate cause for concern regarding the mid-term efficacy of artemether–lumefantrine in Myanmar, while the absence of resistance-conferring pfmdr1 mutations and SVMNT pfcrt haplotypes suggests that amodiaquine could be an efficacious component of anti-malarial regimens in SEA.
AL is an efficacious drug for the treatment of uncomplicated falciparum malaria.
The study revealed the relative effectiveness of the technologies as quality control tools.
Artesunate (100 mg)/lumefantrine (480 mg) fixed-dose combination could add one more option to currently available artemisinin combinations in treatment of uncomplicated P. falciparum malaria.
We aimed to assess whether 3 months of chemoprevention with artemether–lumefantrine reduced this risk.
In Rwanda, frequent mutations in the pfdhfr and pfdhps genes of Plasmodium falciparum have suggested intense sulfadoxine–pyrimethamine resistance.
The therapeutic efficacy, changes in haematocrit and declines in parasitaemias were evaluated in 56 children with uncomplicated falciparum hyperparasitaemia after oral artesunate–amodiaquine or artemether–lumefantrine.
These findings show a substantial benefice of artemether–lumefantrine and artesunate–mefloquine and of new control measures.