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artemether–lumefantrine

Absence of in vivo selection for K13 mutations after artemether–lumefantrine treatment in Uganda

January 14, 2017 - 16:17 -- Open Access
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Author(s): 
Betty Balikagala, Toshihiro Mita, Takafumi Tsuboi, et al.
Reference: 
Malaria Journal 2017 16:23, 9 January 2017

Mutations in pfkelch13 and the six background genes may not play an important role in the in vivo selection after artemether–lumefantrine treatment in Uganda.

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Analysis of anti-malarial resistance markers in pfmdr1 and pfcrt across Southeast Asia in the Tracking Resistance to Artemisinin Collaboration

November 10, 2016 - 17:39 -- Open Access
Author(s): 
Krongkan Srimuang, Olivo Miotto, Pharath Lim, Rick M. Fairhurst, Dominic P. Kwiatkowski, Charles J. Woodrow and Mallika Imwong
Reference: 
Malaria Journal 2016 15:541, 8 November 2016

These findings generate cause for concern regarding the mid-term efficacy of artemether–lumefantrine in Myanmar, while the absence of resistance-conferring pfmdr1 mutations and SVMNT pfcrt haplotypes suggests that amodiaquine could be an efficacious component of anti-malarial regimens in SEA.

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Therapeutic efficacy of artemether–lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria from three highly malarious states in India

October 18, 2016 - 18:21 -- Open Access
Author(s): 
Praveen K. Bharti, Man M. Shukla, Neeru Singh, et al.
Reference: 
Malaria Journal 2016 15:498, 13 October 2016

AL is an efficacious drug for the treatment of uncomplicated falciparum malaria.

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Assessment of the effectiveness of the CD3+ tool to detect counterfeit and substandard anti-malarials

March 1, 2016 - 17:47 -- Open Access
Author(s): 
JaCinta S. Batson, Daniel K. Bempong, Patrick H. Lukulay, Nicola Ranieri, R. Duane Satzger and Leigh Verbois
Reference: 
Malaria Journal 2016 15:119, 25 February 2016

The study revealed the relative effectiveness of the technologies as quality control tools.

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NOT Open Access | Comparative evaluation of efficacy and safety of artesunate–lumefantrine vs. artemether–lumefantrine fixed-dose combination in the treatment of uncomplicated Plasmodium falciparum malaria

April 11, 2013 - 08:21 -- NOT Open Access
Author(s): 
Anil Pareek, Nitin Chandurkar, Sucheta Lakhani, et al.
Reference: 
Tropical Medicine & International Health, Volume 18, Issue 5, pages 578–587, May 2013
MalariaWorld

Artesunate (100 mg)/lumefantrine (480 mg) fixed-dose combination could add one more option to currently available artemisinin combinations in treatment of uncomplicated P. falciparum malaria.

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Intermittent preventive therapy for malaria with monthly artemether–lumefantrine for the post-discharge management of severe anaemia in children aged 4–59 months in southern Malawi: a multicentre, randomised, placebo-controlled trial

February 24, 2012 - 13:16 -- Patrick Sampao
Author(s): 
Kamija Phiri, Michael Esan, Michael Boele van Hensbroek, Carole Khairallah, Brian Faragher, Feiko O ter Kuile
Reference: 
The Lancet Infectious Diseases, Volume 12, Issue 3, March 2012, Pages 191-200

MalariaWorldWe aimed to assess whether 3 months of chemoprevention with artemether–lumefantrine reduced this risk.

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Molecular markers of Plasmodium falciparum drug resistance in southern highland Rwanda

November 17, 2011 - 11:18 -- Kabogo Ndegwa
Author(s): 
Irene Zeile, Jean-Bosco Gahutu, Cyprien Shyirambere, Christian Steininger, Andre Musemakweri, Fidèle Sebahungu, Corine Karema, Gundel Harms, Teunis A. Eggelte, Frank P. Mockenhaupt
Reference: 
Acta Tropica, Volume 121, Issue 1, January 2012, Pages 50-54

MalariaWorldIn Rwanda, frequent mutations in the pfdhfr and pfdhps genes of Plasmodium falciparum have suggested intense sulfadoxine–pyrimethamine resistance.

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Oral Artesunate–Amodiaquine and Artemether–Lumefantrine in the Treatment of Uncomplicated Hyperparasitaemic Plasmodium falciparum Malaria in Children

May 31, 2011 - 11:25 -- Kabogo Ndegwa
Author(s): 
Grace O. Gbotosho, Akintunde Sowunmi, Titilope M. Okuboyejo, Christian T. Happi
Reference: 
J Trop Pediatr (2011)

The therapeutic efficacy, changes in haematocrit and declines in parasitaemias were evaluated in 56 children with uncomplicated falciparum hyperparasitaemia after oral artesunate–amodiaquine or artemether–lumefantrine.

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Increased prevalence of the Plasmodium falciparum Pfmdr1 86N genotype among field isolates from Franceville, Gabon after replacement of chloroquine by artemether–lumefantrine and artesunate–mefloquine

March 1, 2011 - 08:11 -- Patrick Sampao
Author(s): 
Jean Bernard Lekana-Douki.,Sylvatrie Danne Dinzouna Boutamba., Fousseyni S. Toure-Ndouo., et al.
Reference: 
Infection, Genetics and Evolution, Volume 11, Issue 2, March 2011, Pages 512-517

These findings show a substantial benefice of artemether–lumefantrine and artesunate–mefloquine and of new control measures.

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