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epitopes

Open Access | Induction of strain-transcendent antibodies to placental-type isolates with VAR2CSA DBL3 or DBL5 recombinant proteins

February 15, 2011 - 09:18 -- Kabogo Ndegwa
Author(s): 
Avril M, Cartwright MM, Hathaway MJ, Smith JD
Reference: 
Malaria Journal 2011, 10:36 (11 February 2011)

Single domain VAR2CSA recombinant proteins produced in P. pastoris had limited efficacy in eliciting adhesion blocking antibody responses, but VAR2CSA DBL3 and DBL5 domains contain strain-transcendent epitopes that can be targeted by vaccination and may have application for vaccine development.

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