The early appearance of gametocytes indicates gametocyte commitment during the first wave of asexual parasites emerging from the liver.
Phenotypic screening methods have had a profound impact on antimalarial drug development, but assays that predict which compounds might provide a radical cure have remained elusive.
The CRIMALDDI Consortium has been a three-year project funded by the EU Framework Seven Programme.
Plasmodium falciparum, the deadliest malarial parasite species, has developed resistance against nearly all man-made antimalarial drugs within the past century.
For decades, drug resistance has been the major obstacle in the fight against malaria, and the search for new drugs together with the combination therapy constitutes the major approach in responding to this situation.
This is the first study to report baseline information on the characteristics and implications of anti-malarial drug resistance markers in Yemen.
The study affirms Pfcrt as a better chloroquine resistance marker.
Reports of potential drug-resistant strains of Plasmodium malariae in western Indonesia raise concerns that chloroquine resistance may be emerging in P. malariae and P. ovale.
More efforts should be focused on disseminating pre-travel advice to immigrants planning to visit friends and relatives and travelers on self-organized trips.
During the blood meal of a Plasmodium-infected mosquito, 10 to 100 parasites are inoculated into the skin and a proportion of these migrate via the bloodstream to the liver where they infect hepatocytes.