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amodiaquine

Population Pharmacokinetic and Pharmacodynamic Modeling of Amodiaquine and Desethylamodiaquine in Women with Plasmodium vivax Malaria during and after Pregnancy

October 17, 2012 - 07:36 -- Kabogo Ndegwa
Author(s): 
Joel Tarning, Palang Chotsiri, Vincent Jullien, Marcus J. Rijken, Martin Bergstrand, Mireille Cammas, Rose McGready, Pratap Singhasivanon, Nicholas P. J. Day, Nicholas J. White, Francois Nosten, and Niklas Lindegard
Reference: 
Antimicrob. Agents Chemother. November 2012 vol. 56 no. 11 5764-5773

MalariaWorldAmodiaquine is effective for the treatment of Plasmodium vivax malaria, but there is little information on the pharmacokinetic and pharmacodynamic properties of amodiaquine in pregnant women with malaria.

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NOT Open Access | A Simple Dose Regimen of Artesunate and Amodiaquine Based on Arm Span- or Age Range for Childhood Falciparum Malaria: A Preliminary Evaluation

August 7, 2012 - 11:42 -- Kabogo Ndegwa
Author(s): 
Akintunde Sowunmi, Ibukun A. Akinrinola, Grace O. Gbotosho, Titilope M. Okuboyejo, and Christian T. Happi
Reference: 
J Trop Pediatr (2012) 58 (4): 263-268

MalariaWorldA dose regimen of artesunate and amodiaquine based on arm span- or age range (DRAAAS), derived from a study of 1674 children, was compared with standard dose regimen of the same drugs calculated according to body weight (SDRAA) in 68 malarious children.

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NOT Open Access | Crystal structure of phosphoethanolamine methyltransferase from Plasmodium falciparum in complex with amodiaquine

July 20, 2012 - 11:55 -- Kabogo Ndegwa
Author(s): 
Soon Goo Lee, Tara D. Alpert, Joseph M. Jez
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 22, Issue 15, 1 August 2012, Pages 4990–4993

MalariaWorldPhosphoethanolamine N-methyltransferase (PMT) is essential for phospholipid biogenesis in the malarial parasite Plasmodium falciparum.

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Open Access | Capillary electrophoresis for the assay of fixed-dose combination tablets of artesunate and amodiaquine

May 8, 2012 - 14:10 -- Kabogo Ndegwa
Author(s): 
Amin N, Blanchin M, Aké M, Montels J, Fabre H
Reference: 
Malaria Journal 2012, 11:149 (3 May 2012)

MalariaWorldThe MEKC method proposed is reliable for the determination of artesunate and amodiaquine hydrochloride in fixed-dose combination tablets.

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Open Access | Distribution of human CYP2C8*2 allele in three different African populations

May 2, 2012 - 07:44 -- Kabogo Ndegwa
Author(s): 
Paganotti GM, Gramolelli S, Tabacchi F, Russo G, Modiano D, Coluzzi M, Romano R
Reference: 
Malaria Journal 2012, 11:125 (25 April 2012)

MalariaWorldThis study demonstrated that CYP2C8*2 allele is widespread in Africa.

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A Simple Dose Regimen of Artesunate and Amodiaquine Based on Arm Span- or Age Range for Childhood Falciparum Malaria: A Preliminary Evaluation

November 8, 2011 - 08:23 -- Kabogo Ndegwa
Author(s): 
Akintunde Sowunmi, Ibukun A. Akinrinola, Grace O. Gbotosho, Titilope M. Okuboyejo, and Christian T. Happi
Reference: 
J Trop Pediatr (2011)

MalariaWorldA dose regimen of artesunate and amodiaquine based on arm span- or age range (DRAAAS), derived from a study of 1674 children, was compared with standard dose regimen of the same drugs calculated according to body weight (SDRAA) in 68 malarious children.

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Amodiaquine analogues containing NO-donor substructures: Synthesis and their preliminary evaluation as potential tools in the treatment of cerebral malaria

March 28, 2011 - 12:26 -- Kabogo Ndegwa
Author(s): 
Massimo Bertinaria, Stefano Guglielmo, Barbara Rolando, Marta Giorgis, Cristina Aragno, Roberta Fruttero, Alberto Gasco, Silvia Parapini, Donatella Taramelli, Yuri C. Martins, Leonardo J.M. Carvalho
Reference: 
European Journal of Medicinal Chemistry, Volume 46, Issue 5, May 2011, Pages 1757-1767

The synthesis and physico-chemical properties of novel compounds obtained by conjugation of amodiaquine with moieties containing either furoxan or nitrooxy NO-donor substructures are described.

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Open Access | Two Strategies for the Delivery of IPTc in an Area of Seasonal Malaria Transmission in The Gambia: A Randomised Controlled Trial

February 7, 2011 - 08:02 -- Kabogo Ndegwa
Author(s): 
Kalifa A. Bojang, Francis Akor, Lesong Conteh, Emily Webb, Ousman Bittaye, David J. Conway, Momodou Jasseh, Virginia Wiseman, Paul J. Milligan, Brian Greenwood
Reference: 
PLoS Med 8(2): e1000409

In this setting in The Gambia, delivery of IPTc to children 6 years of age and under by VHWs is more effective and less costly than delivery through RCH trekking clinics.

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Open Access | A trial of intermittent preventive treatment and home-based management of malaria in a rural area of The Gambia

January 12, 2011 - 10:04 -- Kabogo Ndegwa
Author(s): 
Sesay S, Milligan P, Touray E, Sowe M, Webb EL, Greenwood BM, Bojang KA
Reference: 
Malaria Journal 2011, 10:2 (7 January 2011)

Due to the very low incidence of malaria, no firm conclusion can be drawn on the added benefit of IPTc in preventing clinical episodes of malaria among children who had access to HMM in The Gambia.

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Open Access | Increased prevalence of the pfdhfr/phdhps quintuple mutant and rapid emergence of pfdhps resistance mutations at codons 581 and 613 in Kisumu, Kenya

November 26, 2010 - 10:15 -- Kabogo Ndegwa
Author(s): 
Spalding MD, Eyase FL, Akala HM, Bedno SA, Prigge ST, Coldren RL, Moss WJ, Waters NC
Reference: 
Malaria Journal 2010, 9:338 (24 November 2010)

During the period in which SP was the first-line anti-malarial in Kenya, highly SP-resistant parasites emerged, including isolates harboring pfdhps mutations not previously observed there.

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