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plasmepsin II

Antimalarial evaluation of copper(II) nanohybrid solids: inhibition of plasmepsin II, a hemoglobin-degrading malarial aspartic protease from Plasmodium falciparum

January 14, 2011 - 13:07 -- Patrick Sampao
Author(s): 
Subash Chandra Mohapatra., Hemandra Kumar Tiwari.,Shyam Singh Chauhan., et al.
Reference: 
Journal of Biological Inorganic Chemistry, Volume 15, Number 3, 373-385

Our results suggest that these two compounds have antimalarial activities, and the IC50 values (0.025–0.032 μg/ml) are similar to the IC50 value of the standard drug chloroquine used in the bioassay. Lineweaver–Burk plots for inhibition of plasmepsin II by LCu(CH3COO)2 and LCuCl2 show that the inhibition is competitive with respect to the substrate.

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