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artemisinin-based combination therapies

NOT Open Access | Conditioned media and organic elicitors underpin the production of potent antiplasmodial metabolites by endophytic fungi from Cameroonian medicinal plants

July 26, 2018 - 16:16 -- NOT Open Access
Tags: 
Author(s): 
Rufin Marie Kouipou Toghueo, Dinkar Sahal, Íñigo Zabalgogeazcoa, Bill Baker & Fabrice Fekam Boyom
Reference: 
Parasitology Research, August 2018, Volume 117, Issue 8, pp 2473–2485

Plasmodial resistance to artemisinin-based combination therapies emphasizes the need for new drug development to control malaria.

Women's Access and Provider Practices for the Case Management of Malaria during Pregnancy: A Systematic Review and Meta-Analysis

September 4, 2014 - 11:46 -- Open Access
Author(s): 
Jenny Hill, Lauren D'Mello-Guyett, Jenna Hoyt, Anna M. van Eijk, Feiko O. ter Kuile, Jayne Webster
Reference: 
PLoS Med 11(8): e1001688

A systematic assessment of the extent of substandard case management practices of malaria in pregnancy is required, as well as quality improvement interventions that reach all providers administering antimalarial drugs in the community.

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NOT Open Access | Effect of Single Nucleotide Polymorphisms in Cytochrome P450 Isoenzyme and N-Acetyltransferase 2 Genes on the Metabolism of Artemisinin-Based Combination Therapies in Malaria Patients from Cambodia and Tanzania

January 24, 2013 - 13:50 -- NOT Open Access
Author(s): 
Eva Maria Staehli Hodel, Chantal Csajka, Frédéric Ariey, Monia Guidi, Abdunoor Mulokozi Kabanywanyi, Socheat Duong, Laurent Arthur Decosterd, Piero Olliaro, Hans-Peter Beck, and Blaise Genton
Reference: 
Antimicrob. Agents Chemother. February 2013 vol. 57 no. 2 950-958
MalariaWorld

The pharmacogenetics of antimalarial agents are poorly known, although the application of pharmacogenetics might be critical in optimizing treatment.

Efficacy of different primaquine-based antimalarial regimens against Plasmodium falciparum gametocytemia

March 6, 2012 - 08:14 -- Kabogo Ndegwa
Author(s): 
Eliana M. Arango, Yulieth A. Upegui, Jaime Carmona-Fonseca
Reference: 
Acta Tropica, Volume 122, Issue 2, May 2012, Pages 177–182

MalariaWorldThis study compared the efficacy against Plasmodium falciparum gametocytes of four regimens:

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In Vivo and In Vitro Antimalarial Properties of Azithromycin-Chloroquine Combinations That Include the Resistance Reversal Agent Amlodipine

June 21, 2011 - 06:51 -- Kabogo Ndegwa
Author(s): 
Marcus R. Pereira, Philipp P. Henrich, Amar bir Singh Sidhu, David Johnson, Joel Hardink, Jeffrey Van Deusen, Jian Lin, Katrina Gore, Connor O'Brien, Mamadou Wele, Abdoulaye Djimde, Richa Chandra, David A. Fidock
Reference: 
Antimicrobial Agents and Chemotherapy, July 2011,p. 3115-3124, Vol. 55, No. 7

Evidence of emerging Plasmodium falciparum resistance to artemisinin-based combination therapies, documented in western Cambodia, underscores the continuing need to identify new antimalarial combinations.

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Open Access | Chloroquine-induced Pruritus

January 3, 2011 - 08:50 -- Kabogo Ndegwa
Author(s): 
SE Aghahowa, HO Obianwu, AO Isah, IM Arhewoh
Reference: 
Indian Journal of Pharmaceutical Sciences, 2010, Volume: 72, Issue: 3, Page: 283-289

Chloroquine-induced pruritus remains one of the most common side-effects in the use of chloroquine in the prophylaxis and treatment of uncomplicated malaria before the advent of artemisinin-based combination therapies.

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