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immunization

Not Open Access | Effect of intermittent preventive treatment for malaria during infancy on serological responses to measles and other vaccines used in the Expanded Programme on Immunization: results from five randomised controlled trials

September 18, 2012 - 17:10 -- Patrick Sampao
Author(s): 
Jane Crawley, Charalambos Sismanidis, Tracey Goodman, Paul Milligan
Reference: 
The Lancet, Volume 380, Issue 9846, 15–21 September 2012, Pages 1001-1010

http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(12)60775-2/abstractThe study was done in a subset of children enrolled in five randomised controlled trials in Navrongo, Ghana; Kilimanjaro, Tanzania; Manhica, Mozambique; Kisumu, Kenya; and Bungoma, Kenya.

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Restricted | Antigen-Specific IL-2 Secretion Correlates with NK Cell Responses after Immunization of Tanzanian Children with the RTS,S/AS01 Malaria Vaccine

May 8, 2012 - 12:44 -- Kabogo Ndegwa
Author(s): 
Amir Horowitz, Julius C. R. Hafalla, Eleanor M. Riley, et al.
Reference: 
The Journal of Immunology May 15, 2012 vol. 188 no. 10 5054-5062

MalariaWorldRTS,S/AS01, a vaccine targeting pre-erythrocytic stages of Plasmodium falciparum, is undergoing clinical trials.

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Extrahepatic exoerythrocytic forms of rodent malaria parasites at the site of inoculation: Clearance after immunization, susceptibility to primaquine and contribution to blood stage infection

March 21, 2012 - 06:59 -- Patrick Sampao
Author(s): 
Tatiana Voza, Jessica L. Miller, Stefan H.I. Kappe and Photini Sinnis
Reference: 
Infection and Immunity, volume 80, issue 4

MalariaWorldOur studies demonstrate that skin exoerythrocytic stages are susceptible to destruction in immunized mice, suggesting that their aberrant location does not protect them from the host's adaptive immune response.

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Short Report: Immunization with genetically attenuated P52-deficient Plasmodium berghei sporozoites induces a long-lasting effector memory CD8+ T cell response in the liver

October 27, 2011 - 14:41 -- Open Access
Author(s): 
Bruno Douradinha, Melissa van Dijk, Sabrina Epiphanio, et al.
Reference: 
Journal of Immune Based Therapies and Vaccines 2011, 9:6

MalariaWorldWe demonstrate that immunization with p52-GAP sporozoites also results in a strong increase of effector memory CD8+ T cells, even 6 months after immunization, whereas no specific CD4+ effector T cells response could be detected. In addition, we show that the increase of effector memory CD8+ T cells is specific for the liver and not for the spleen or lymph nodes.

 

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Immunization with the RTS,S/AS malaria vaccine induces IFN-γ +CD4 T cells that recognize only discrete regions of the circumsporozoite protein and these specificities are maintained following booster immunizations and challenge

October 24, 2011 - 15:13 -- Patrick Sampao
Author(s): 
Robert Schwenk, Joanne M. Lumsden, Lisa E. Rein, Laure Juompan, Kent E. Kester, D. Gray Heppner, Urszula Krzych
Reference: 
Vaccine, Volume 29, Issue 48, 8 November 2011, Pages 8847-8854

MalariaWorldWe conclude that processing of the CS protein derived from the RTS,S antigen leads to the generation of HLA-DR-restricted epitopes that are similar to those identified previously using CD4 T cells from subjects immunized with and protected by attenuated sporozoites or exposed to infectious sporozoites.

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Open Access | The antibody response to Plasmodium falciparum Merozoite Surface Protein 4: comparative assessment of specificity and growth inhibitory antibody activity to infection-acquired and immunization-induced epitopes

September 21, 2011 - 13:05 -- Patrick Sampao
Author(s): 
Harini D de Silva, Suha Saleh, Svetozar Kovacevic, Lina Wang, Casilda G Black, Magdalena Plebanski, Ross L Coppel
Reference: 
Malaria Journal 2011, 10:266 (16 September 2011)

The panel of MSP4-specific Mabs produced were found to recognize six distinct epitopes that are also targeted by human antibodies during natural malaria infection.

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Long-Term Humoral and Cellular Immune Responses Elicited by a Heterologous Plasmodium vivax Apical Membrane Antigen 1 Protein Prime/Adenovirus Boost Immunization Protocol

September 8, 2011 - 09:14 -- Patrick Sampao
Author(s): 
Leoneide Érica Maduro Bouillet, Mariana Oliveira Dias, Oscar Bruna-Romero, et al.
Reference: 
Infect. Immun., Sep 2011; 79: 3642 - 3652.

We show here that when it is administered as a recombinant protein (P) in Montanide ISA720 adjuvant, followed by a recombinant human type 5 adenovirus (Ad), intense and long-lasting Plasmodium vivax AMA-1-specific antibody responses (including both IgG1 and IgG2a), as well as proliferative memory T cell responses, can be detected in immunized mice.

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Long-Term Humoral and Cellular Immune Responses Elicited by a Heterologous Plasmodium vivax Apical Membrane Antigen 1 Protein Prime/Adenovirus Boost Immunization Protocol

August 17, 2011 - 09:51 -- Patrick Sampao
Author(s): 
Leoneide Érica Maduro Bouillet, Mariana Oliveira Dias, Oscar Bruna-Romero, et al.
Reference: 
Infect. Immun., Sep 2011; 79: 3642 - 3652.

These results give further support to the need for preclinical studies of P. vivax vaccine candidate AMA-1 administered in prime/boost protocols that include recombinant proteins and adenoviral vectors.

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Cutting Edge: Attrition of Plasmodium-Specific Memory CD8 T Cells Results in Decreased Protection That Is Rescued by Booster Immunization

March 22, 2011 - 11:32 -- Kabogo Ndegwa
Author(s): 
Nathan W. Schmidt and John T. Harty
Reference: 
The Journal of Immunology April 1, 2011 vol. 186 no. 7 3836-3840

Sterile protection against infection with Plasmodium sporozoites requires high numbers of memory CD8 T cells.

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Open Access | Immunization with different PfAMA1 alleles in sequence induces clonal imprint humoral responses that are similar to responses induced by the same alleles as a vaccine cocktail in rabbits

February 16, 2011 - 06:57 -- Kabogo Ndegwa
Author(s): 
Kusi KA, Faber BW, van der Eijk M, Thomas AW, Kocken CH, Remarque EJ
Reference: 
Malaria Journal 2011, 10:40 (14 February 2011)

These findings may have implications for the current understanding of the natural acquisition of clinical immunity to malaria as well as for rational vaccine design.

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