Plasmodium falciparum causes the most severe malaria pathogen and has developed resistance to existing drugs making it indispensable to discover new drugs. In order to predict drug targets in silico, a useful model for the metabolism is needed.
Infection, Genetics and Evolution, Volume 11, Issue 4, June 2011, Pages 708-715
Infection, Genetics and Evolution, Volume 11, Issue 1, January 2011, Pages 201-208
Comparing the modeling results with a comprehensive list of known drug targets for P. falciparum, showed that we had the best discovery success with a network model consisting only of enzymes from the parasite alone which coding genes were known.