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antiplasmodial 8-aminoquinoline

Tafenoquine, an Antiplasmodial 8-Aminoquinoline, Targets Leishmania Respiratory Complex III and Induces Apoptosis

November 19, 2010 - 11:33 -- Kabogo Ndegwa
Luis Carvalho, Juan Román Luque-Ortega, José Ignacio Manzano, Santiago Castanys, Luis Rivas, and Francisco Gamarro
Antimicrobial Agents and Chemotherapy, December 2010, p. 5344-5351, Vol. 54, No. 12

Tafenoquine (TFQ), an 8-aminoquinoline analogue of primaquine, which is currently under clinical trial (phase IIb/III) for the treatment and prevention of malaria, may represent an alternative treatment for leishmaniasis.

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