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NOT Open Access | High Risk of QT Interval Prolongation and Torsades de Pointes Associated with Intravenous Quinidine Used for Treatment of Resistant Malaria or Babesiosis

July 24, 2012 - 11:50 -- Kabogo Ndegwa
Heather A. Wroblewski, Richard J. Kovacs, Joanna R. Kingery, Brian R. Overholser, and James E. Tisdale
Antimicrob. Agents Chemother. August 2012 vol. 56 no. 8 4495-4499

MalariaWorldCardiac toxicity may be associated with drugs used for malaria. Torsades de pointes (TdP) is a well-known adverse effect of quinidine when used for atrial fibrillation.

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Open Access | Effects of anti-malarial drugs on the electrocardiographic QT interval modelled in the isolated perfused guinea pig heart system

November 16, 2010 - 13:13 -- Kabogo Ndegwa
Atsushi Kinoshita, Harumi Yamada, Hajime Kotaki, Mikio Kimura
Malaria Journal 2010, 9:318 (10 November 2010)

In this study, an isolated, perfused guinea pig heart system was constructed to assess the cardiotoxic potential of anti-malarial drugs.

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