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adenovirus

Long-Term Humoral and Cellular Immune Responses Elicited by a Heterologous Plasmodium vivax Apical Membrane Antigen 1 Protein Prime/Adenovirus Boost Immunization Protocol

September 8, 2011 - 09:14 -- Patrick Sampao
Author(s): 
Leoneide Érica Maduro Bouillet, Mariana Oliveira Dias, Oscar Bruna-Romero, et al.
Reference: 
Infect. Immun., Sep 2011; 79: 3642 - 3652.

We show here that when it is administered as a recombinant protein (P) in Montanide ISA720 adjuvant, followed by a recombinant human type 5 adenovirus (Ad), intense and long-lasting Plasmodium vivax AMA-1-specific antibody responses (including both IgG1 and IgG2a), as well as proliferative memory T cell responses, can be detected in immunized mice.

Medical Condition: 

Tailoring subunit vaccine immunogenicity: Maximizing antibody and T cell responses by using combinations of adenovirus, poxvirus and protein-adjuvant vaccines against Plasmodium falciparum MSP1

October 12, 2010 - 08:18 -- Patrick Sampao
Author(s): 
Alexander D. Douglas, Simone C. de Cassan, Matthew D.J. Dicks, Sarah C. Gilbert, Adrian V.S. Hill, Simon J. Draper
Reference: 
Vaccine, Volume 28, Issue 44, 18 October 2010, Pages 7167-7178

Here, we demonstrate in mice using a Plasmodium falciparum merozoite surface protein 1 (PfMSP1) antigen that novel regimes combining adenovirus and poxvirus vectored vaccines with protein antigen in Montanide ISA720 adjuvant can achieve simultaneous antibody and T cell responses which equal, or in some cases surpass, the best immune responses achieved by either the viral vectors or the protein vaccine alone.

Medical Condition: 
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