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Long-Term Humoral and Cellular Immune Responses Elicited by a Heterologous Plasmodium vivax Apical Membrane Antigen 1 Protein Prime/Adenovirus Boost Immunization Protocol

September 8, 2011 - 09:14 -- Patrick Sampao
Leoneide Érica Maduro Bouillet, Mariana Oliveira Dias, Oscar Bruna-Romero, et al.
Infect. Immun., Sep 2011; 79: 3642 - 3652.

We show here that when it is administered as a recombinant protein (P) in Montanide ISA720 adjuvant, followed by a recombinant human type 5 adenovirus (Ad), intense and long-lasting Plasmodium vivax AMA-1-specific antibody responses (including both IgG1 and IgG2a), as well as proliferative memory T cell responses, can be detected in immunized mice.

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Tailoring subunit vaccine immunogenicity: Maximizing antibody and T cell responses by using combinations of adenovirus, poxvirus and protein-adjuvant vaccines against Plasmodium falciparum MSP1

October 12, 2010 - 08:18 -- Patrick Sampao
Alexander D. Douglas, Simone C. de Cassan, Matthew D.J. Dicks, Sarah C. Gilbert, Adrian V.S. Hill, Simon J. Draper
Vaccine, Volume 28, Issue 44, 18 October 2010, Pages 7167-7178

Here, we demonstrate in mice using a Plasmodium falciparum merozoite surface protein 1 (PfMSP1) antigen that novel regimes combining adenovirus and poxvirus vectored vaccines with protein antigen in Montanide ISA720 adjuvant can achieve simultaneous antibody and T cell responses which equal, or in some cases surpass, the best immune responses achieved by either the viral vectors or the protein vaccine alone.

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