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pyrimethamine

Not Open Access | Pharmacokinetic Properties and Bioequivalence of Two Sulfadoxine/Pyrimethamine Fixed-Dose Combination Tablets: A Parallel-Design Study in Healthy Chinese Male Volunteers

November 12, 2012 - 16:13 -- NOT Open Access
Author(s): 
Yan-Mei Liu, Kanyin E. Zhang, Chen Yu, et al.
Reference: 
Clinical Therapeutics, Volume 34, Issue 11, November 2012, Pages 2212-2220

MalariaWorldThe aim of the present study was to compare the pharmacokinetic profiles between a new generic and the branded reference formulation of sulfadoxine/pyrimethamine FDC tablets, and to assess the bioequivalence of the 2 products in healthy Chinese volunteers.

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Molecular assessment of dhfr/dhps mutations among Plasmodium vivax clinical isolates after introduction of sulfadoxine/pyrimethamine in combination with artesunate in Iran

December 16, 2011 - 14:30 -- Patrick Sampao
Author(s): 
Mandana Afsharpad, Sedigheh Zakeri, Sakineh Pirahmadi, Navid D. Djadid
Reference: 
Infection, Genetics and Evolution, Volume 12, Issue 1, January 2012, Pages 38-44

MalariaWorldIn conclusion, the present results suggest that SP could be effective in treatment against the erythrocytic stages of vivax malaria in Iran; however, the increased frequency of mutant haplotypes in Iran since 2006 is worrying and indicates the emergence of drug-tolerant/resistant P. vivax isolates in Iran in near future.

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Efficacy of intermittent preventive treatment with sulfadoxine–pyrimethamine on placental parasitemia in pregnant women in midwestern Nigeria

December 14, 2010 - 08:21 -- Patrick Sampao
Author(s): 
Michael E. Aziken, Kenneth K. Akubuo, Etedafe P. Gharoro
Reference: 
International Journal of Gynecology & Obstetrics, Volume 112, Issue 1, January 2011, Pages 30-33

To assess the effect of intermittent preventive treatment with sulfadoxine and pyrimethamine (IPT-SP) on placental parasitemia and maternal and perinatal outcome.

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Open Access | Synopsis: Sulfadoxine/Pyrimethamine Intermittent Preventive Treatment for Malaria during Pregnancy

October 26, 2010 - 11:39 -- Patrick Sampao
Author(s): 
Philippe Deloron, Gwladys Bertin, Valérie Briand, Achille Massougbodji, and Michel Cot
Reference: 
Emerging Infectious Diseases, Volume 16, Number 11–November 2010

The World Health Organization recently proposed conducting in vivo studies in pregnant women to evaluate molecular markers for detecting resistance precociously.

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Pyrimethamine induces oxidative stress in Plasmodium yoelii 17XL-infected mice: A novel immunomodulatory mechanism of action for an old antimalarial drug?

September 10, 2010 - 13:23 -- Kabogo Ndegwa
Author(s): 
Martha Legorreta-Herrera, Raquel Retana-Ugalde, José Luis Ventura-Gallegos, Verónica Narváez
Reference: 
Experimental Parasitology, Volume 126, Issue 3, November 2010, Pages 381-388

Pyrimethamine is an antimalarial drug that has also been used successfully to treat autoimmune diseases such as lymphoproliferative syndrome. In this work, the effect of pyrimethamine (PYR) on the production of free radicals in malaria-infected mice was studied to better understand the drug’s immunomodulatory properties. BALB/c and CBA/Ca mice were infected with Plasmodium yoelii 17XL.

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Open Access | Drug coverage in treatment of malaria and the consequences for resistance evolution - evidence from the use of sulphadoxine/pyrimethamine

July 6, 2010 - 06:52 -- Kabogo Ndegwa
Author(s): 
Malisa AL, Pearce RJ, Abdulla S, Mshinda H, Kachur PS, Bloland P, Roper C
Reference: 
Malaria Journal 2010, 9:190 (5 July 2010)

The national policy change brought about a shift in treatment practice and the resulting increase in coverage had a substantial impact on drug pressure.

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Mechanisms of Resistance: Evidence of Selective Sweeps in Genes Conferring Resistance to Chloroquine and Pyrimethamine in Plasmodium falciparum Isolates in India

February 25, 2010 - 21:28 -- Kabogo Ndegwa
Author(s): 
Tonya Mixson-Hayden, Vidhan Jain, Neeru Singh et al.
Reference: 
Antimicrobial Agents and Chemotherapy, March 2010, Pages 997-1006, Volume 54, No. 3

We tested whether chloroquine- and antifolate drug-resistant genotypes would be more commonly associated with cases of cerebral malaria than with cases of mild malaria in the province of Jabalpur, India, by genotyping the dhps, dhfr, pfmdr-1, and pfcrt genes using pyrosequencing, direct sequencing, and real-time PCR.

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Mechanisms of Resistance; Characteristics of Genetic Hitchhiking around Dihydrofolate Reductase Gene Associated with Pyrimethamine Resistance in Plasmodium falciparum Isolates from India .

November 18, 2009 - 12:34 -- Patrick Sampao
Author(s): 
Vanshika Lumb, Manoj K. Das, Neeru Singh, Vas Dev, Wajihullah,4 and Yagya D. Sharma
Reference: 
Antimicrobial Agents and Chemotherapy, December 2009, p. 5173-5180, Vol. 53, No. 12, doi:10.1128/AAC.00045-09

Sulfadoxine-pyrimethamine (SP) resistance in Plasmodium falciparum has been widespread across continents, causing the major hurdle of controlling malaria. Resistance is encoded mainly by point mutations in P. falciparum dihydrofolate reductase (pfdhfr) and dihydropteroate synthase (pfdhps) target genes. To study the origin and evolution of pyrimethamine resistance on the Indian subcontinent, microsatellite markers flanking the pfdhfr gene were mapped. Here we describe the characteristics of genetic hitchhiking around the pfdhfr gene among 190 P. falciparum isolates.

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