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quinine

Limited Ability of Plasmodium falciparum pfcrt, pfmdr1, and pfnhe1 Polymorphisms To Predict Quinine In Vitro Sensitivity or Clinical Effectiveness in Uganda

January 25, 2011 - 06:39 -- Kabogo Ndegwa
Author(s): 
Frederick N. Baliraine, Samuel L. Nsobya, Jane Achan, James K. Tibenderana, Ambrose O. Talisuna, Bryan Greenhouse, and Philip J. Rosenthal
Reference: 
Antimicrobial Agents and Chemotherapy, February 2011, p. 615-622, Vol. 55, No. 2

Quinine is a standard drug for treating severe malaria in Africa, and it is also increasingly used to treat uncomplicated disease.

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Plasmodium falciparum: Solanum nudum SN-1 steroid antiplasmodial activity when combined with antimalarial drugs

January 4, 2011 - 06:25 -- Kabogo Ndegwa
Author(s): 
Adriana Pabón, Eric Deharo, Silvia Blair
Reference: 
Experimental Parasitology, Volume 127, Issue 1, January 2011, Pages 222-227

The effect of 16 alpha-acetoxy-26-hydroxycholest-4-ene-3,22-dione (SN-1) isolated from Solanum nudum Dunal (a Solanaceae traditionally used for treating fever in Colombia) on Plasmodium falciparum erythrocyte stages and its in vitro antiplasmodial activity when combined with the following conventional drugs was studied: chloroquine (CQ), amodiaquine (AQ), desethylamodiaquine (desethyl-AQ), quinine (QN), artemisinin (AR), atovaquone (ATV) and quinine (QN).

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Open Access | Hypoglycaemia in severe malaria, clinical associations and relationship to quinine dosage

November 25, 2010 - 10:47 -- Patrick Sampao
Author(s): 
Gilbert N Ogetii , Samuel Akech , Julie Jemutai , Mwanamvua Boga , Esther Kivaya , Greg Fegan and Kathryn Maitland
Reference: 
BMC Infectious Diseases 2010, 10:334doi:10.1186/1471-2334-10-334

There was no evidence to indicate a dose relationship between quinine and occurrence of hypoglycaemia. Hypoglycaemia concurred with severity features, disruption of glucose infusion and transfusion. Careful glucose monitoring should be targeted to these complications where resources are limited.

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Open Access | Modulating effects of plasma containing anti-malarial antibodies on in vitro anti-malarial drug susceptibility in Plasmodium falciparum

November 17, 2010 - 08:43 -- Kabogo Ndegwa
Author(s): 
Preeyaporn Monatrakul, Mathirut Mungthin, Arjen M Dondorp, Srivicha Krudsood, Rachanee Udomsangpetch, Polrat Wilairatana, Nicholas J White, Kesinee Chotivanich
Reference: 
Malaria Journal 2010, 9:326 (16 November 2010)

'Immune' plasma containing anti-malarial antibodies inhibits parasite development and multiplication and increases apparent in vitro anti-malarial drug susceptibility of P. falciparum.

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Open Access | Effects of anti-malarial drugs on the electrocardiographic QT interval modelled in the isolated perfused guinea pig heart system

November 16, 2010 - 13:13 -- Kabogo Ndegwa
Author(s): 
Atsushi Kinoshita, Harumi Yamada, Hajime Kotaki, Mikio Kimura
Reference: 
Malaria Journal 2010, 9:318 (10 November 2010)

In this study, an isolated, perfused guinea pig heart system was constructed to assess the cardiotoxic potential of anti-malarial drugs.

Fast Track: Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial

November 15, 2010 - 13:43 -- Patrick Sampao
Author(s): 
Arjen M Dondorp, Caterina I Fanello, Juliet Mwanga-Amumpaire et al.
Reference: 
The Lancet, Volume 376, Issue 9753, 13 November 2010-19 November 2010, Pages 1647-1657

These data, together with a meta-analysis of all trials comparing artesunate and quinine, strongly suggest that parenteral artesunate should replace quinine as the treatment of choice for severe falciparum malaria worldwide.

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Open Access | Factors determining anti-malarial drug use in a peri-urban population from malaria holoendemic region of western Kenya

October 30, 2010 - 12:14 -- Kabogo Ndegwa
Author(s): 
Watsierah CA, Jura WG, Oyugi H, Abong'o B, Ouma C
Reference: 
Malaria Journal 2010, 9:295 (26 October 2010)

This study demonstrates that consumers require access to correct and comprehensible information associated with use of drugs, including self-prescription.

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In Vitro Sensitivity of Plasmodium falciparum Clinical Isolates from the China-Myanmar Border Area to Quinine and Association with Polymorphism in the Na+/H+ Exchanger

September 21, 2010 - 07:31 -- Kabogo Ndegwa
Author(s): 
Hao Meng, Rongping Zhang, Henglin Yang, Qi Fan, Xinzhuan Su, Jun Miao, Liwang Cui, and Zhaoqing Yang
Reference: 
Antimicrobial Agents and Chemotherapy, October 2010, p. 4306-4313, Vol. 54, No. 10

Quinine resistance (QNR) in Plasmodium falciparum has been detected in many regions of the world where malaria is endemic. Genetic polymorphisms in at least four genes are implicated in QN susceptibility, and their significance often depends on the genetic background of the parasites.

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Short Communication: Comparison of artesunate and quinine in the treatment of Sudanese children with severe Plasmodium falciparum malaria

September 20, 2010 - 13:25 -- Patrick Sampao
Author(s): 
Hatim G. Eltahir, Abubaker A. Omer, Ayoub A. Mohamed, Ishag Adam
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 104, Issue 10, October 2010, Pages 684-686

Sixty-six children presenting to Singa hospital, Sudan with different manifestations of severe Plasmodium falciparum malaria were randomly divided into two well-matched groups (33 in each arm) to receive either intravenous artesunate 2•4 mg/kg at 0, 12, and 24 hours, then daily, or intravenous quinine 20 mg/kg initially then 10 mg/kg three times a day.

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Absence of Association between Piperaquine In Vitro Responses and Polymorphisms in the pfcrt, pfmdr1, pfmrp, and pfnhe Genes in Plasmodium falciparum

August 18, 2010 - 12:43 -- Kabogo Ndegwa
Author(s): 
Sébastien Briolant, Maud Henry, Claude Oeuvray, Rémy Amalvict, Eric Baret, Eric Didillon, Christophe Rogier, and Bruno Pradines
Reference: 
Antimicrobial Agents and Chemotherapy, September 2010, p. 3537-3544, Vol. 54, No. 9

We have analyzed the profiles of 23 of Plasmodium falciparum strains for their in vitro chemosusceptibilities to piperaquine (PPQ), dihydroartemisinin (DHA), chloroquine, monodesethylamodiaquine, quinine, mefloquine, lumefantrine, atovaquone, pyrimethamine, and doxycycline (DOX) in association with polymorphisms in genes involved in quinoline resistance (Plasmodium falciparum crt [pfcrt], pfmdr1, pfmrp, and pfnhe).

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