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quinine

NOT Open Access | Quinoline-based antimalarial hybrid compounds

August 12, 2015 - 14:27 -- NOT Open Access
Author(s): 
Stéphanie Vandekerckhove, Matthias D’hooghe
Reference: 
Bioorganic & Medicinal Chemistry, Volume 23, Issue 16, 15 August 2015, Pages 5098–5119

Quinoline-containing compounds, such as quinine and chloroquine, have a long-standing history as potent antimalarial agents.

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An operational comparative study of quinine and artesunate for the treatment of severe malaria in hospitals and health centres in the Democratic Republic of Congo: the MATIAS study

June 2, 2015 - 08:42 -- Open Access
Tags: 
Author(s): 
Giovanfrancesco Ferrari, Henry Ntuku, Christian Lengeler, et al.
Reference: 
Malaria Journal 2015, 14:226 (30 May 2015)

This study demonstrates that injectable artesunate in the DRC is easier to use and it costs less than injectable quinine.

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The Mu Subunit of Plasmodium falciparum Clathrin-Associated Adaptor Protein 2 Modulates In Vitro Parasite Response to Artemisinin and Quinine

April 14, 2015 - 17:32 -- Open Access
Author(s): 
Gisela Henriques, Donelly A. van Schalkwyk, Rebekah Burrow, David C. Warhurst, Eloise Thompson, David A. Baker, David A. Fidock, Rachel Hallett, Christian Flueck, and Colin J. Sutherland
Reference: 
Antimicrob. Agents Chemother. May 2015 vol. 59 no. 5 2540-2547

The emergence of drug-resistant parasites is a serious threat faced by malaria control programs.

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Atovaquone and quinine anti-malarials inhibit ATP binding cassette transporter activity

September 19, 2014 - 14:30 -- Open Access
Author(s): 
Rijpma SR, van den Heuvel JJ, van der Velden M, Sauerwein RW, Russel FG, Koenderink JB
Reference: 
Malaria Journal 2014, 13 :359 (13 September 2014)

Atovaquone and quinine significantly inhibit BCRP- and P-gp- mediated transport at concentrations within the clinically relevant prophylactic and therapeutic range.

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A HECT Ubiquitin-Protein Ligase as a Novel Candidate Gene for Altered Quinine and Quinidine Responses in Plasmodium falciparum

May 20, 2014 - 09:41 -- Open Access
Author(s): 
Cecilia P. Sanchez, Chia-Hao Liu, Sybille Mayer, Astutiati Nurhasanah, Marek Cyrklaff, Jianbing Mu, Michael T. Ferdig, Wilfred D. Stein, Michael Lanzer
Reference: 
PLoS Genet 10(5): e1004382

The emerging resistance to quinine jeopardizes the efficacy of a drug that has been used in the treatment of malaria for several centuries.

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CYP450 phenotyping and metabolite identification of quinine by accurate mass UPLC-MS analysis: a possible metabolic link to blackwater fever

June 26, 2013 - 10:17 -- Open Access
Tags: 
Author(s): 
Marcsisin SR, Jin X, Bettger T, McCulley N, Sousa JC, Shanks GD, Tekwani BL, Sahu R, Reichard GA, Sciotti RJ, Melendez V, Pybus BS
Reference: 
Malaria Journal 2013, 12:214 (21 June 2013)
MalariaWorld

Taken in context, these data suggest a CYP-mediated link between quinine metabolism and the poorly understood haemolytic condition known as blackwater fever, often associated with quinine ingestion.

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Quinine localizes to a non-acidic compartment within the food vacuole of the malaria parasite Plasmodium falciparum

October 23, 2012 - 14:56 -- Patrick Sampao
Author(s): 
Bohórquez EB, Chua M, Meshnick SR
Reference: 
Malaria Journal 2012, 11:350 (22 October 2012)

MalariaWorldFluorescence microscopy was used to evaluate the subcellular localization of quinine in parasites containing different pfmdr1 copy numbers to determine if copy number of the gene affects drug localization.

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Evaluation of the physicochemical equivalence of three brands of commercially available quinine sulphate tablets from South Western part of Nigeria.

July 20, 2012 - 14:52 -- Patrick Sampao
Author(s): 
Adegbite A, Adegbolagun OM
Reference: 
Afr Health Sci. 2011 Jun;11(2):197-203

MalariaWorldTo evaluate the physicochemical and equivalency of three brands of quinine sulphate tablets available in South Western region of Nigeria.

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NOT Open Access | Artesunate versus quinine for treating severe malaria.

June 20, 2012 - 14:57 -- Patrick Sampao
Author(s): 
Sinclair D, Donegan S, Isba R, Lalloo DG.
Reference: 
Cochrane Database Syst Rev. 2012 Jun 13;6

MalariaWorldThis review examines whether treatment with artesunate, instead of the standard treatment quinine, would result in fewer deaths and better treatment outcomes.

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Open Access | Artemether-lumefantrine to treat malaria in pregnancy is associated with reduced placental haemozoin deposition compared to quinine in a randomized controlled trial

May 9, 2012 - 07:10 -- Kabogo Ndegwa
Author(s): 
Muehlenbachs A, Nabasumba C, McGready R, Turyakira E, Tumwebaze B, Dhorda M, Nyehangane D, Nalusaji A, Nosten F, Guerin PJ, Piola P
Reference: 
Malaria Journal 2012, 11:150 (3 May 2012)

MalariaWorldPlacental haemozoin deposition was decreased in the AL arm demonstrating a relationship between pharmacological properties of drug to treat antenatal malaria and placental pathology at delivery.

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