Quinoline-containing compounds, such as quinine and chloroquine, have a long-standing history as potent antimalarial agents.
This study demonstrates that injectable artesunate in the DRC is easier to use and it costs less than injectable quinine.
The emergence of drug-resistant parasites is a serious threat faced by malaria control programs.
Atovaquone and quinine significantly inhibit BCRP- and P-gp- mediated transport at concentrations within the clinically relevant prophylactic and therapeutic range.
The emerging resistance to quinine jeopardizes the efficacy of a drug that has been used in the treatment of malaria for several centuries.
Taken in context, these data suggest a CYP-mediated link between quinine metabolism and the poorly understood haemolytic condition known as blackwater fever, often associated with quinine ingestion.
Fluorescence microscopy was used to evaluate the subcellular localization of quinine in parasites containing different pfmdr1 copy numbers to determine if copy number of the gene affects drug localization.
To evaluate the physicochemical and equivalency of three brands of quinine sulphate tablets available in South Western region of Nigeria.
This review examines whether treatment with artesunate, instead of the standard treatment quinine, would result in fewer deaths and better treatment outcomes.
Placental haemozoin deposition was decreased in the AL arm demonstrating a relationship between pharmacological properties of drug to treat antenatal malaria and placental pathology at delivery.