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Low Anticoagulant Heparin Disrupts Plasmodium falciparum Rosettes in Fresh Clinical Isolates

March 3, 2011 - 12:08 -- Patrick Sampao
Author(s): 
Anna M. Leitgeb, Karin Blomqvist, Fidelis Cho-Ngwa, Moses Samje, Peter Nde, Vincent Titanji, AND Mats Wahlgren
Reference: 
Am J Trop Med Hyg, Mar 2011; 84: 390 - 396.

Herein, we report that two different LAHs (DFX232 and Sevuparin) disrupt rosettes in the majority of fresh isolates from Cameroonian children with malaria. The rosette disruption effect was more pronounced in isolates from complicated cases than from mild cases. The data support LAH as adjunct therapy in severe malaria.

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Open Access | Hypoglycaemia in severe malaria, clinical associations and relationship to quinine dosage

November 25, 2010 - 10:47 -- Patrick Sampao
Author(s): 
Gilbert N Ogetii , Samuel Akech , Julie Jemutai , Mwanamvua Boga , Esther Kivaya , Greg Fegan and Kathryn Maitland
Reference: 
BMC Infectious Diseases 2010, 10:334doi:10.1186/1471-2334-10-334

There was no evidence to indicate a dose relationship between quinine and occurrence of hypoglycaemia. Hypoglycaemia concurred with severity features, disruption of glucose infusion and transfusion. Careful glucose monitoring should be targeted to these complications where resources are limited.

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Open Access | Chloroquine Clinical Failures in P. falciparum Malaria Are Associated with Mutant Pfmdr-1, Not Pfcrt in Madagascar

October 17, 2010 - 14:45 -- Patrick Sampao
Author(s): 
Valérie A., Arsène R., et al.
Reference: 
PLoS ONE 5(10) e13281

These results highlight the limits of the current in vitro tests routinely used to monitor CQ drug resistance in this unique context. Gaining insight about the mechanisms that regulate polymorphism in Pfmdr1 remains important, particularly regarding the evolution and spread of Pfmdr-1 alleles in P. falciparum populations under changing drug pressure which may have important consequences in terms of antimalarial use management.

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Case Reports: pfmdr1 Amplification Associated with Clinical Resistance to Mefloquine in West Africa: Implications for Efficacy of Artemisinin Combination Therapies

October 1, 2010 - 09:36 -- Patrick Sampao
Author(s): 
Benoit W., Xavier I., et al.
Reference: 
J. Clin. Microbiol., Oct 2010; 48: 3797 - 3799.

We describe here a clinical failure in the treatment with mefloquine of acute falciparum malaria contracted in Africa and associated with in vitro mefloquine resistance and pfmdr1 copy number amplification.

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