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piperaquine

NOT Open Access | Baseline Ex Vivo and Molecular Responses of Plasmodium falciparum Isolates to Piperaquine before Implementation of Dihydroartemisinin-Piperaquine in Senegal

April 30, 2019 - 15:21 -- NOT Open Access
Author(s): 
Marie Gladys Robert, Francis Foguim Tsombeng, Mathieu Gendrot, Silman Diawara, Marylin Madamet, Mame Bou Kounta, Khalifa Ababacar Wade, Mansour Fall, Mamadou Wague Gueye, Nicolas Benoit, Aminata Nakoulima, Raymond Bercion, Rémy Amalvict, Bécaye Fall, Boubacar Wade, Bakary Diatta and Bruno Pradines
Reference: 
Antimicrob. Agents Chemother. April 2019 63:e02445-18

Dihydroartemisinin-piperaquine, which was registered in 2017 in Senegal, is not currently used as the first-line treatment against uncomplicated malaria. A total of 6.6% to 17.1% of P. falciparum isolates collected in Dakar in 2013 to 2015 showed ex vivo-reduced susceptibility to piperaquine. 

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Population Pharmacokinetic Assessment of the Effect of Food on Piperaquine Bioavailability in Patients with Uncomplicated Malaria

March 19, 2014 - 13:18 -- Open Access
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Author(s): 
Joel Tarning, Niklas Lindegardh, Khin Maung Lwin, Anna Annerberg, Lily Kiricharoen, Elizabeth Ashley, Nicholas J. White, François Nosten, and Nicholas P. J. Day
Reference: 
Antimicrob. Agents Chemother. April 2014 vol. 58 no. 4 2052-2058

Previously published literature reports various impacts of food on the oral bioavailability of piperaquine.

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A population pharmacokinetic model of piperaquine in pregnant and non-pregnant women with uncomplicated Plasmodium falciparum malaria in Sudan

December 4, 2012 - 07:50 -- Open Access
Author(s): 
Hoglund RM, Adam I, Hanpithakpong W, Ashton M, Lindegardh N, Day NP, White NJ, Nosten F, Tarning J
Reference: 
Malaria Journal 2012, 11:398 (29 November 2012)
MalariaWorld

The population pharmacokinetic properties of piperaquine were well described by a three-compartment disposition model in pregnant and non-pregnant women with uncomplicated malaria.

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Pharmacokinetics of Piperaquine in Pregnant Women in Sudan with Uncomplicated Plasmodium falciparum Malaria

July 4, 2012 - 13:12 -- Patrick Sampao
Author(s): 
Ishag Adam, Joel Tarning, Niklas Lindegardh, Hyder Mahgoub, Rose McGready and François Nosten
Reference: 
Am J Trop Med Hyg 2012 87:35-40

MalariaWorldThe overall pharmacokinetic properties of piperaquine in this study were consistent with previously published reports in non-pregnant patients.

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Open Access | Population Pharmacokinetics of Dihydroartemisinin and Piperaquine in Pregnant and Nonpregnant Women with Uncomplicated Malaria

March 22, 2012 - 06:47 -- Kabogo Ndegwa
Author(s): 
Joel Tarning, Marcus J. Rijken, Rose McGready, Aung Pyae Phyo, Warunee Hanpithakpong, Nicholas P. J. Day, Nicholas J. White, François Nosten, and Niklas Lindegardh
Reference: 
Antimicrob. Agents Chemother. April 2012 vol. 56 no. 4 1997-2007

MalariaWorldPregnant women are particularly vulnerable to malaria. The pharmacokinetic properties of antimalarial drugs are often affected by pregnancy, resulting in lower drug concentrations and a consequently higher risk of treatment failure.

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Open Access | Population Pharmacokinetics and Pharmacodynamics of Piperaquine in Children With Uncomplicated Falciparum Malaria

February 17, 2012 - 14:14 -- Patrick Sampao
Author(s): 
J Tarning, I Zongo, F A Somé, N Rouamba, S Parikh, P J Rosenthal, W Hanpithakpong, N Jongrak, N P J Day, N J White, F Nosten, J-B Ouedraogo and N Lindegardh
Reference: 
Clinical Pharmacology & Therapeutics (2012); 91 3, 497–505.

MalariaWorldThe aim of this study was to describe the pharmacokinetic and pharmacodynamic properties of piperaquine in 236 children with uncomplicated falciparum malaria in Burkina Faso.

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Open Access | Pharmacokinetics and Disposition: Comparison of plasma, venous and capillary blood levels of piperaquine in patients with uncomplicated falciparum malaria

January 14, 2011 - 12:37 -- Patrick Sampao
Author(s): 
Elizabeth A. Ashley., Kasia Stepniewska.,François Nosten., et al.
Reference: 
European Journal of Clinical Pharmacology, Volume 66, Number 7, 705-712

The aim of this study was to describe the relationship between piperaquine concentrations measured in capillary blood, venous blood and venous plasma.

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In Vitro Activity of Pyronaridine against Multidrug-Resistant Plasmodium falciparum and Plasmodium vivax

November 19, 2010 - 11:38 -- Kabogo Ndegwa
Author(s): 
R. N. Price, J. Marfurt, F. Chalfein, E. Kenangalem, K. A. Piera, E. Tjitra, N. M. Anstey, and B. Russell
Reference: 
Antimicrobial Agents and Chemotherapy, December 2010, p. 5146-5150, Vol. 54, No. 12

Pyronaridine, a Mannich base antimalarial, has demonstrated high in vivo and in vitro efficacy against chloroquine-resistant Plasmodium falciparum.

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Absence of Association between Piperaquine In Vitro Responses and Polymorphisms in the pfcrt, pfmdr1, pfmrp, and pfnhe Genes in Plasmodium falciparum

August 18, 2010 - 12:43 -- Kabogo Ndegwa
Author(s): 
Sébastien Briolant, Maud Henry, Claude Oeuvray, Rémy Amalvict, Eric Baret, Eric Didillon, Christophe Rogier, and Bruno Pradines
Reference: 
Antimicrobial Agents and Chemotherapy, September 2010, p. 3537-3544, Vol. 54, No. 9

We have analyzed the profiles of 23 of Plasmodium falciparum strains for their in vitro chemosusceptibilities to piperaquine (PPQ), dihydroartemisinin (DHA), chloroquine, monodesethylamodiaquine, quinine, mefloquine, lumefantrine, atovaquone, pyrimethamine, and doxycycline (DOX) in association with polymorphisms in genes involved in quinoline resistance (Plasmodium falciparum crt [pfcrt], pfmdr1, pfmrp, and pfnhe).

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Investigation of reproductive toxicity of piperaquine in mice

March 26, 2010 - 16:48 -- Kabogo Ndegwa
Author(s): 
Kevin T. Batty, Brioni R. Moore, Verity Stirling, Kenneth F. Ilett, Madhu Page-Sharp, Keith B. Shilkin, Ivo Mueller, Stephen J. Rogerson, Harin A. Karunajeewa, Timothy M.E. Davis
Reference: 
Reproductive Toxicology, Volume 29, Issue 2, April 2010, Pages 206-213

Although we found no significant PQ toxicity, clinical data are lacking and monitoring of women and their infants for biochemical and haematological adverse effects is recommended when PQ is used in pregnancy.

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