The world's scientific and social network for malaria professionals
Subscribe to free Newsletter | 10493 malaria professionals are enjoying the free benefits of MalariaWorld today

chloroquine

In vitro antimalarial activity of ICL670: A further proof of the correlation between inhibition of β-hematin formation and of peroxidative degradation of hemin

March 28, 2011 - 11:58 -- Kabogo Ndegwa
Author(s): 
P. Sonnet, C. Mullié
Reference: 
Experimental Parasitology, Volume 128, Issue 1, May 2011, Pages 26-31

Iron chelators such as deferiprone, deferoxamine (DFO) and ICL670 (deferasirox) have previously been shown to display in vitro and/or in vivo antimalarial activities.

Medical Treatment: 

Thiostrepton and Derivatives Exhibit Antimalarial and Gametocytocidal Activity by Dually Targeting Parasite Proteasome and Apicoplast

March 22, 2011 - 11:38 -- Kabogo Ndegwa
Author(s): 
Makoah N. Aminake, Sebastian Schoof, Ludmilla Sologub, Monika Leubner, Marc Kirschner, Hans-Dieter Arndt, and Gabriele Pradel
Reference: 
Antimicrobial Agents and Chemotherapy, April 2011, p. 1338-1348, Vol. 55, No. 4

Ribosome-targeting antibiotics exert their antimalarial activity on the apicoplast of the malaria parasite, an organelle of prokaryote origin having essential metabolic functions.

Medical Condition: 
Medical Treatment: 

In vitro antiplasmodial activity of ethanolic extracts of mangrove plants from South East coast of India against chloroquine-sensitive Plasmodium falciparum

March 22, 2011 - 11:05 -- Kabogo Ndegwa
Author(s): 
Sundaram Ravikumar, Samuel Jacob Inbaneson, Palavesam Suganthi & Murugesan Gnanadesigan
Reference: 
Parasitology Research, Volume 108, Number 4, 873-878

Malaria is one of the most prevalent infectious diseases in the world. Treatment for malaria is commonly inadequate due to the lack of quality assured effective drugs.

Medical Condition: 
Medical Treatment: 

Screening of antiplasmodial efficacy of Ajuga bracteosa Wall ex. Benth

March 22, 2011 - 10:01 -- Kabogo Ndegwa
Author(s): 
Sanjeev Chandel & Upma Bagai
Reference: 
Parasitology Research, Volume 108, Number 4, 801-805

The rising problem of Plasmodium resistance to the classical antimalarial drugs stresses the need to look for newer antiplasmodial components with effective and new mode of action.

Medical Condition: 
Medical Treatment: 

Synthesis and biological evaluation of benzimidazole-5-carbohydrazide derivatives as antimalarial, cytotoxic and antitubercular agents

March 15, 2011 - 07:38 -- Kabogo Ndegwa
Author(s): 
José Camacho, Arthur Barazarte, Neira Gamboa, Juan Rodrigues, Rosario Rojas, Abraham Vaisberg, Robert Gilman, Jaime Charris
Reference: 
Bioorganic & Medicinal Chemistry, Volume 19, Issue 6, 15 March 2011, Pages 2023-2029

A series of N′-substituted-2-(5-nitrofuran or 5-nitrothiophen-2-yl)-3H-benzo[d]imidazole-5-carbohydrazide derivatives were synthesized and investigated for their abilities to inhibit β-hematin formation, hemoglobin hydrolysis and in vivo for their antimalarial efficacy in rodent Plasmodium berghei.

Medical Condition: 
Medical Treatment: 

Synthesis, in vitro antimalarial and cytotoxicity of artemisinin-aminoquinoline hybrids

March 9, 2011 - 08:13 -- Kabogo Ndegwa
Author(s): 
Marli C. Lombard, David D. N’Da, Jaco C. Breytenbach, Peter J. Smith, Carmen A. Lategan
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 21, Issue 6, 15 March 2011, Pages 1683-1686c

Dihydroartemisinin (DHA) was coupled to different aminoquinoline moieties forming hybrids 9–14, which were then treated with oxalic acid to form oxalate salts (9a–14a).

An automated, polymer-assisted strategy for the preparation of urea and thiourea derivatives of 15-membered azalides as potential antimalarial chemotherapeutics

March 2, 2011 - 08:36 -- Kabogo Ndegwa
Author(s): 
Antun Hutinec, Renata Rupčić, Dinko Žiher, Kirsten S. Smith, Wilbur Milhous, William Ellis, Colin Ohrt, Zrinka Ivezić Schönfeld
Reference: 
Bioorganic & Medicinal Chemistry, Volume 19, Issue 5, 1 March 2011, Pages 1692-1701

A series of 15-membered azalide urea and thiourea derivatives has been synthesized and evaluated for their in vitro antimalarial activity against chloroquine-sensitive (D6), chloroquine/pyremethamine resistant (W2) and multidrug resistant (TM91C235) strains of Plasmodium falciparum.

Medical Condition: 
Medical Treatment: 

Increased prevalence of the Plasmodium falciparum Pfmdr1 86N genotype among field isolates from Franceville, Gabon after replacement of chloroquine by artemether–lumefantrine and artesunate–mefloquine

March 1, 2011 - 08:11 -- Patrick Sampao
Author(s): 
Jean Bernard Lekana-Douki.,Sylvatrie Danne Dinzouna Boutamba., Fousseyni S. Toure-Ndouo., et al.
Reference: 
Infection, Genetics and Evolution, Volume 11, Issue 2, March 2011, Pages 512-517

These findings show a substantial benefice of artemether–lumefantrine and artesunate–mefloquine and of new control measures.

Country: 

The Presence of Leukocytes in Ex Vivo Assays Significantly Increases the 50-Percent Inhibitory Concentrations of Artesunate and Chloroquine against Plasmodium vivax and Plasmodium falciparum

March 1, 2011 - 06:34 -- Kabogo Ndegwa
Author(s): 
S. Kaewpongsri, K. Sriprawat, R. Suwanarusk, D. E. Kyle, U. Lek-Uthai, M. Leimanis, K. M. Lwin, A. P. Phyo, J. Zwang, B. Russell, F. Nosten, and L. Renia
Reference: 
Antimicrobial Agents and Chemotherapy, March 2011, p. 1300-1304, Vol. 55, No. 3

Plasmodium species ex vivo sensitivity assay protocols differ in the requirement for leukocyte removal before culturing.

Medical Treatment: 

Open Access | Ex Vivo Activity of Histone Deacetylase Inhibitors against Multidrug-Resistant Clinical Isolates of Plasmodium falciparum and P. vivax

March 1, 2011 - 06:28 -- Kabogo Ndegwa
Author(s): 
Jutta Marfurt, Ferryanto Chalfein, Pak Prayoga, Frans Wabiser, Enny Kenangalem, Kim A. Piera, David P. Fairlie, Emiliana Tjitra, Nicholas M. Anstey, Kathy T. Andrews, and Ric N. Price
Reference: 
Antimicrobial Agents and Chemotherapy, March 2011, p. 961-966, Vol. 55, No. 3

Histone acetylation plays an important role in regulating gene transcription and silencing in Plasmodium falciparum.

Medical Condition: 
Medical Treatment: 

Pages

Subscribe to RSS - chloroquine