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chloroquine

Open Access | Chloroquine resistant vivax malaria in a pregnant woman on the western border of Thailand

May 10, 2011 - 08:01 -- Kabogo Ndegwa
Author(s): 
Marcus J Rijken, Machteld E Boel, Bruce Russell, Mallika Imwong, Mara L Leimanis, Aung Pyae Phyo, Atis Muehlenbachs, Niklas Lindegardh, Rose McGready, Laurent Renia, Georges Snounou, Pratap Singhasivanon, Francois Nosten
Reference: 
Malaria Journal 2011, 10:113 (5 May 2011)

Chloroquine (CQ) resistant vivax malaria is spreading. In this case, Plasmodium vivax infections during pregnancy and in the postpartum period were not satisfactorily cleared by CQ, despite adequate drug concentrations.

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Dibenzylideneacetone analogues as novel Plasmodium falciparum inhibitors

May 4, 2011 - 12:47 -- Kabogo Ndegwa
Author(s): 
Rahul Balasaheb Aher, Gajanan Wanare, Neha Kawathekar, Ravi Ranjan Kumar, Naveen Kumar Kaushik, Dinkar Sahal, Virander Singh Chauhan
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 21, Issue 10, 15 May 2011, Pages 3034-3036

A series of dibenzylideneacetones (A1–A12) and some of their pyrazolines (B1–B4) were synthesized and evaluated in vitro for blood stage antiplasmodial properties in Plasmodium falciparum culture using SYBR-green-I fluorescence assay.

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Open Access | Parasitostatic effect of maslinic acid. I. Growth arrest of Plasmodium falciparum intraerythrocytic stages

April 20, 2011 - 11:55 -- Kabogo Ndegwa
Author(s): 
Carlos Moneriz, Patricia Marin-Garcia, Andres Garcia-Granados, Jose M Bautista, Amalia Diez, Antonio Puyet
Reference: 
Malaria Journal 2011, 10:82 (10 April 2011)

MA displays anti-malarial activity at multiple intraerythrocytic stages of the parasite and, depending on the dose and incubation time, behaves as a plasmodial parasitostatic compound.

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Antiplasmodial activity of botanical extracts against Plasmodium falciparum

April 20, 2011 - 07:49 -- Kabogo Ndegwa
Author(s): 
Asokan Bagavan, Abdul Abdul Rahuman, Chinnaperumal Kamaraj, Naveen Kumar Kaushik, Dinesh Mohanakrishnan & Dinkar Sahal
Reference: 
Parasitology Research, Volume 108, Number 5, 1099-1109

The absence of a vaccine and the rampant resistance to almost all antimalarial drugs have accentuated the urgent need for new antimalarial drugs and drug targets for both prophylaxis and chemotherapy.

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Human p38 mitogen-activated protein kinase inhibitor drugs inhibit Plasmodium falciparum replication

April 14, 2011 - 12:35 -- Kabogo Ndegwa
Author(s): 
Michael J. Brumlik, Standwell Nkhoma, Mark J. Kious, George R. Thompson III, Thomas F. Patterson, John J. Siekierka, Tim J.C. Anderson, Tyler J. Curiel
Reference: 
Experimental Parasitology, Volume 128, Issue 2, June 2011, Pages 170-175

We recently demonstrated that human p38 mitogen-activated protein kinase (MAPK) inhibitors reduced in vitro and in vivo replication of the protozoan parasites Toxoplasma gondii and Encephalitozoon cuniculi.

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Aryl piperazine and pyrrolidine as antimalarial agents. Synthesis and investigation of structure–activity relationships

April 14, 2011 - 12:14 -- Kabogo Ndegwa
Author(s): 
Adela Mendoza, Silvia Pérez-Silanes, Miguel Quiliano, Adriana Pabón, Silvia Galiano, Germán González, Giovanny Garavito, Mirko Zimic, Abraham Vaisberg, Ignacio Aldana, Antonio Monge, Eric Deharo
Reference: 
Experimental Parasitology, Volume 128, Issue 2, June 2011, Pages 97-103

Piperazine and pyrrolidine derivatives were synthesised and evaluated for their capacity to inhibit the growth of Plasmodium falciparum chloroquine-resistant (FCR-3) strain in culture.

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Mechanism of Endosomal TLR Inhibition by Antimalarial Drugs and Imidazoquinolines

April 7, 2011 - 07:15 -- Kabogo Ndegwa
Author(s): 
Alenka Kuznik, Mojca Bencina, Urban Svajger, Matjaz Jeras, Blaz Rozman, and Roman Jerala
Reference: 
The Journal of Immunology April 15, 2011 vol. 186 no. 8 4794-4804

Endosomal TLRs play an important role in innate immune response as well as in autoimmune processes.

Open Access | Simple flow cytometric detection of haemozoin containing leukocytes and erythrocytes for research on diagnosis, immunology and drug sensitivity testing

April 5, 2011 - 08:40 -- Kabogo Ndegwa
Author(s): 
Frita R, Rebelo M, Pamplona A, Vigario AM, Mota MM, Grobusch MP, Hanscheid T
Reference: 
Malaria Journal 2011, 10:74 (31 March 2011)

A simple modification of a flow cytometer allows for rapid and reliable detection and quantification of Hz-containing leukocytes and the analysis of differential surface marker expression in the same sample of Hz-containing versus non-Hz-containing leukocytes.

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Short Report: Therapeutic Efficacy of Chloroquine in Plasmodium vivax and the pvmdr1 Polymorphisms in the Republic of Korea Under Mass Chemoprophylaxis

April 4, 2011 - 14:13 -- Patrick Sampao
Author(s): 
Young Keun Kim, Changsoo Kim, Inho Park, Hyo Youl Kim, Jun Yong Choi, AND June Myung Kim
Reference: 
Am J Trop Med Hyg, Apr 2011; 84: 532 - 534.

We investigated the therapeutic efficacy of HCQ and the pvmdr1 gene polymorphisms in P. vivax. From June to September 2006, 102 soldiers with vivax malaria near the demilitarized zone in Gyeonggi-do, ROK, were enrolled in the study.

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A series of structurally simple chloroquine chemosensitizing dibemethin derivatives that inhibit chloroquine transport by PfCRT

March 28, 2011 - 12:33 -- Kabogo Ndegwa
Author(s): 
Vincent K. Zishiri, Roger Hunter, Peter J. Smith, Dale Taylor, Robert Summers, Kiaran Kirk, Rowena E. Martin, Timothy J. Egan
Reference: 
European Journal of Medicinal Chemistry, Volume 46, Issue 5, May 2011, Pages 1729-1742

A series of 12 new dibemethin (N-benzyl-N-methyl-1-phenylmethanamine) derivatives bearing an N-aminomethyl group attached to the one phenyl ring and an H, Cl, OCH3 or N(CH3)2 group on the other have been synthesized.

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