4-Aminoquinolines were hybridized with artemisinin and 1,4-naphthoquinone derivatives via the Ugi-four-component condensation reaction, and their biological activities investigated.
Evidence of emerging Plasmodium falciparum resistance to artemisinin-based combination therapies, documented in western Cambodia, underscores the continuing need to identify new antimalarial combinations.
The antimalarial drug chloroquine is eliminated to a significant extent by renal tubular secretion.
This work uses a linear-time algorithm for finding paths in a network under modified biologically motivated constraints. We predicted several important signalling transduction pathways in Plasmodium falciparum. We have predicted a viable signalling pathway characterized in terms of the genes responsible that may be the PfPKB pathway recently elucidated in Plasmodium falciparum.
A significant intersection between antimalarial and antiprion activity is well established for certain compound classes, specifically for polycyclic antimalarial agents bearing basic nitrogen-containing sidechains (e.g., chloroquine, quinacrine, mefloquine).
In this study we investigate the cytocidal potency of CQ and other common quinoline antimalarial drugs (quantified as LD50).
The antimalarial and antioxidant activities of methanolic extract of Nigella sativa seeds (MENS) were investigated against established malaria infection in vivo using Swiss albino mice.
Across the northern states of the Sudan, the period prevalence of fever is low.
This new assay can offer a rapid and robust platform to screen novel classes of anti-malarial drugs.
This study demonstrates that in 2006-2007 chloroquine and SP continued to be used at high rates in many African countries.