The world's scientific and social network for malaria professionals
Subscribe to free Newsletter | 10241 malaria professionals are enjoying the free benefits of MalariaWorld today

chloroquine

Effects of highly active novel artemisinin–chloroquinoline hybrid compounds on β-hematin formation, parasite morphology and endocytosis in Plasmodium falciparum

June 28, 2011 - 06:57 -- Kabogo Ndegwa
Author(s): 
Tzu-Shean Feng, Eric M. Guantai, Margo Nell, Constance E.J. van Rensburg, Kanyile Ncokazi, Timothy J. Egan, Heinrich C. Hoppe, Kelly Chibale
Reference: 
Biochemical Pharmacology, Volume 82, Issue 3, 1 August 2011, Pages 236-247

4-Aminoquinolines were hybridized with artemisinin and 1,4-naphthoquinone derivatives via the Ugi-four-component condensation reaction, and their biological activities investigated.

Medical Condition: 
Medical Treatment: 

In Vivo and In Vitro Antimalarial Properties of Azithromycin-Chloroquine Combinations That Include the Resistance Reversal Agent Amlodipine

June 21, 2011 - 06:51 -- Kabogo Ndegwa
Author(s): 
Marcus R. Pereira, Philipp P. Henrich, Amar bir Singh Sidhu, David Johnson, Joel Hardink, Jeffrey Van Deusen, Jian Lin, Katrina Gore, Connor O'Brien, Mamadou Wele, Abdoulaye Djimde, Richa Chandra, David A. Fidock
Reference: 
Antimicrobial Agents and Chemotherapy, July 2011,p. 3115-3124, Vol. 55, No. 7

Evidence of emerging Plasmodium falciparum resistance to artemisinin-based combination therapies, documented in western Cambodia, underscores the continuing need to identify new antimalarial combinations.

Medical Condition: 

Molecular Mechanism of Renal Tubular Secretion of the Antimalarial Drug Chloroquine

June 21, 2011 - 06:47 -- Kabogo Ndegwa
Author(s): 
Fabian Müller, Jörg König, Hartmut Glaeser, Ingrid Schmidt, Oliver Zolk, Martin F. Fromm, and Renke Maas
Reference: 
Antimicrobial Agents and Chemotherapy, July 2011,p. 3091-3098, Vol. 55, No. 7

The antimalarial drug chloroquine is eliminated to a significant extent by renal tubular secretion.

Medical Treatment: 

Computational identification of signalling pathways in Plasmodium falciparum

June 2, 2011 - 13:11 -- Patrick Sampao
Author(s): 
Jelili Oyelade, Itunu Ewejobi, Benedikt Brors, Roland Eils, Ezekiel Adebiyi
Reference: 
Infection, Genetics and Evolution, Volume 11, Issue 4, June 2011, Pages 755-764

This work uses a linear-time algorithm for finding paths in a network under modified biologically motivated constraints. We predicted several important signalling transduction pathways in Plasmodium falciparum. We have predicted a viable signalling pathway characterized in terms of the genes responsible that may be the PfPKB pathway recently elucidated in Plasmodium falciparum.

Medical Condition: 
Medical Treatment: 

2,4-Diarylthiazole antiprion compounds as a novel structural class of antimalarial leads

June 2, 2011 - 07:06 -- Kabogo Ndegwa
Author(s): 
Mark J. Thompson, Jennifer C. Louth, Susan M. Little, Beining Chen, Iain Coldham
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 21, Issue 12, 15 June 2011, Pages 3644-3647

A significant intersection between antimalarial and antiprion activity is well established for certain compound classes, specifically for polycyclic antimalarial agents bearing basic nitrogen-containing sidechains (e.g., chloroquine, quinacrine, mefloquine).

Medical Condition: 

Plasmodium falciparum resistance to cytocidal versus cytostatic effects of chloroquine

May 25, 2011 - 14:19 -- Patrick Sampao
Author(s): 
Michelle F. Paguio, Kelly L. Bogle, Paul D. Roepe
Reference: 
Molecular and Biochemical Parasitology, Volume 178, Issues 1-2, July-August 2011, Pages 1-6

In this study we investigate the cytocidal potency of CQ and other common quinoline antimalarial drugs (quantified as LD50).

Technology: 
Medical Condition: 
Medical Treatment: 

Antimalarial and antioxidant activities of methanolic extract of Nigella sativa seeds (black cumin) in mice infected with Plasmodium yoelli nigeriensis

May 25, 2011 - 07:57 -- Kabogo Ndegwa
Author(s): 
Valeelat O. Okeola, Oluwatosin A. Adaramoye, Chiaka M. Nneji, Catherine O. Falade, E. Olatunde Farombi and Olusegun G. Ademowo
Reference: 
Parasitology Research, Volume 108, Number 6, 1507-1512

The antimalarial and antioxidant activities of methanolic extract of Nigella sativa seeds (MENS) were investigated against established malaria infection in vivo using Swiss albino mice.

Medical Condition: 
Medical Treatment: 

Open Access | Self-reported fever, treatment actions and malaria infection prevalence in the northern states of Sudan

May 18, 2011 - 13:27 -- Kabogo Ndegwa
Author(s): 
Khalid A Elmardi, Abdisalan M Noor, Sophie Githinji, Tareg M Abdelgadir, ElFatih M Malik, Robert W Snow
Reference: 
Malaria Journal 2011, 10:128 (15 May 2011)

Across the northern states of the Sudan, the period prevalence of fever is low.

Country: 
Medical Condition: 
Medical Treatment: 

Open Access | Quantum dots: a new tool for anti-malarial drug assays

May 11, 2011 - 12:22 -- Patrick Sampao
Author(s): 
Min-Je Ku, Fernando M Dossin, Youngseon Choi, Carolina B Moraes, Jiyoung Ryu, Rita Song, Lucio H Freitas-Junior
Reference: 
Malaria Journal 2011, 10:118 (9 May 2011)

This new assay can offer a rapid and robust platform to screen novel classes of anti-malarial drugs.

Medical Condition: 
Medical Treatment: 

Open Access | Patterns of chloroquine use and resistance in sub-Saharan Africa: a systematic review of household survey and molecular data

May 11, 2011 - 12:06 -- Patrick Sampao
Author(s): 
Anne EP Frosch, Meera Venkatesan, Miriam K Laufer
Reference: 
Malaria Journal 2011, 10:116 (9 May 2011)

This study demonstrates that in 2006-2007 chloroquine and SP continued to be used at high rates in many African countries.

Continent: 
Medical Condition: 
Medical Treatment: 

Pages

Subscribe to RSS - chloroquine